ChemicalBook > CAS DataBase List > Desogestrel

Desogestrel

Product Name
Desogestrel
CAS No.
54024-22-5
Chemical Name
Desogestrel
Synonyms
Desogestrel for system suitability CRS;Desogen;Desogestrel CRS;org2969;Cyclosa;Dicromil;DESTODENE;Cerazette;DESOGESTREL;DESOGESTRAL
CBNumber
CB2359630
Molecular Formula
C22H30O
Formula Weight
310.47
MOL File
54024-22-5.mol
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Desogestrel Property

Melting point:
109-110°C
alpha 
D20 +55° (chloroform)
Boiling point:
390.62°C (rough estimate)
Density 
1.0169 (rough estimate)
refractive index 
1.5100 (estimate)
storage temp. 
-20°C Freezer
solubility 
Practically insoluble in water, very soluble in methanol, freely soluble in anhydrous ethanol and in methylene chloride.
pka
13.07±0.40(Predicted)
form 
Solid
color 
White to Almost white
Merck 
14,2926
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Safety

Safety Statements 
24/25
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
3
RTECS 
JF7975000
HS Code 
29372390
Hazardous Substances Data
54024-22-5(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P391Collect spillage. Hazardous to the aquatic environment

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
1173235
Product name
Desogestrel
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
100mg
Price
$436
Updated
2024/03/01
Sigma-Aldrich
Product number
32809
Product name
Desogestrel
Purity
VETRANAL
Packaging
25mg
Price
$164
Updated
2022/05/15
Sigma-Aldrich
Product number
1173235
Product name
Desogestrel
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
50mg
Price
$452
Updated
2022/05/15
TCI Chemical
Product number
D4163
Product name
Desogestrel
Purity
>98.0%(HPLC)
Packaging
100mg
Price
$159
Updated
2024/03/01
Cayman Chemical
Product number
23651
Product name
Desogestrel
Purity
≥95%
Packaging
5mg
Price
$61
Updated
2024/03/01
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Desogestrel Chemical Properties,Usage,Production

Description

Desogestrel is a synthetic progestogen. It inhibits ovulation and prevents fertilization in rabbits and mice. Desogestrel inhibits rhodamine 123 efflux, a measure of P-glycoprotein activity, ex vivo in human lymphocytes and CD8+ T cells in a dose-dependent manner. Formulations containing desogestrel have been used as oral contraceptives and for the treatment of polycystic ovary syndrome.

Chemical Properties

White Solid

Originator

Dicromil,Organol ,W. Germany,1981

Uses

A progestogen with low androgenic potency

Definition

ChEBI: Desogestrel is a 17beta-hydroxy steroid and a terminal acetylenic compound. It has a role as a contraceptive drug, a progestin and a synthetic oral contraceptive.

Manufacturing Process

A solution of 1.0 g of 11,11-methylene-18-methyl-delta4-estren-17-one in 33 ml tetrahydrofuran was added to a potassium-acetylide solution in tetrahydrofuran.
After 2 hours of stirring at 0°C to 5°C the reaction mixture was acidified with 2N H2SO4and processed further.
By a chromatographic treatment on silica gel and crystallization from pentane 0.7 g of 11,11-methylene-17α-ethynyl-18-methyl-δ4-estren-17β-ol with a melting point of 109°C to 110°C and an [α]D of +55°C (CHCl3) was obtained.

Therapeutic Function

Progestin

General Description

Desogestrel, (17α)-13-ethyl-11-methylene-18,19-dinorpregn-4-en-20-yn-17-ol, is a 19-nortestosterone analog with good progestin activity. Likethe other progestins, it is orally active and used in combinationwith an estrogen in oral contraceptives. Desogestrel is aprodrug that must be oxidized to the 3-one in vivo to haveprogestational action. CYPs 2C9 and 2C19 have been implicatedin the initial hydroxylation of desogestrel at C3.

Clinical Use

Desogestrel also is a prodrug and is rapidly metabolized in the intestinal mucosa and on first pass through the liver to its active metabolite, etonogestrel (3-ketodesogestrel). Following oral administration, the relative bioavailability for desogestrel is approximately 84%. Desogestrel also exhibits high selectivity for the progesterone receptor and low and rogenic activity, and it does not diminish the beneficial effects of estrogen on the lipid profile.

Desogestrel Preparation Products And Raw materials

Raw materials

Preparation Products

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Desogestrel Suppliers

Nanjing Shizhou Biotechnology Co., Ltd
Tel
025-85563444 15850508050
Fax
18013869214
Email
rose.shi@synzest.com
Country
China
ProdList
269
Advantage
58
Hubei wei shi reagent group ltd., company
Tel
027-02759101766 13125137661
Email
2853877621@qq.com
Country
China
ProdList
5219
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6005
Advantage
61
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44689
Advantage
61
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
10186
Advantage
62
Lianyungang Gabriel Bio-chem Technology Co., Ltd.
Tel
+86 (518) 8548-7361
Fax
+86 (518) 8561-1105
Email
lyggabriel@163.com
Country
China
ProdList
20
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42958
Advantage
64
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View Lastest Price from Desogestrel manufacturers

Sinoway Industrial co., ltd.
Product
Desogestrel 54024-22-5
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
20tons
Release date
2024-03-13
Shaanxi Dideu Medichem Co. Ltd
Product
Desogestrel 54024-22-5
Price
US $1.10/g
Min. Order
1g
Purity
99.0% min
Supply Ability
100 tons min
Release date
2021-05-26
Nantong Guangyuan Chemicl Co,Ltd
Product
Desogestrel 54024-22-5
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000kg
Release date
2023-11-01

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