ChemicalBook > CAS DataBase List > Desogestrel

Desogestrel

Product Name
Desogestrel
CAS No.
54024-22-5
Chemical Name
Desogestrel
Synonyms
Desogestrel for system suitability CRS;Desogen;Desogestrel CRS;org2969;Cyclosa;Dicromil;DESTODENE;Cerazette;DESOGESTREL;DESOGESTRAL
CBNumber
CB2359630
Molecular Formula
C22H30O
Formula Weight
310.47
MOL File
54024-22-5.mol
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Desogestrel Property

Melting point:
109-110°C
alpha 
D20 +55° (chloroform)
Boiling point:
390.62°C (rough estimate)
Density 
1.0169 (rough estimate)
refractive index 
1.5100 (estimate)
storage temp. 
-20°C Freezer
solubility 
Practically insoluble in water, very soluble in methanol, freely soluble in anhydrous ethanol and in methylene chloride.
pka
13.07±0.40(Predicted)
form 
Solid
color 
White to Almost white
Merck 
14,2926
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Safety

Safety Statements 
24/25
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
3
RTECS 
JF7975000
HS Code 
29372390
Hazardous Substances Data
54024-22-5(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P391Collect spillage. Hazardous to the aquatic environment

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
1173235
Product name
Desogestrel
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
100mg
Price
$436
Updated
2024/03/01
Sigma-Aldrich
Product number
32809
Product name
Desogestrel
Purity
VETRANAL
Packaging
25mg
Price
$164
Updated
2022/05/15
Sigma-Aldrich
Product number
1173235
Product name
Desogestrel
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
50mg
Price
$452
Updated
2022/05/15
TCI Chemical
Product number
D4163
Product name
Desogestrel
Purity
>98.0%(HPLC)
Packaging
100mg
Price
$159
Updated
2024/03/01
Cayman Chemical
Product number
23651
Product name
Desogestrel
Purity
≥95%
Packaging
5mg
Price
$61
Updated
2024/03/01
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Desogestrel Chemical Properties,Usage,Production

Description

Desogestrel is a synthetic progestogen. It inhibits ovulation and prevents fertilization in rabbits and mice. Desogestrel inhibits rhodamine 123 efflux, a measure of P-glycoprotein activity, ex vivo in human lymphocytes and CD8+ T cells in a dose-dependent manner. Formulations containing desogestrel have been used as oral contraceptives and for the treatment of polycystic ovary syndrome.

Chemical Properties

White Solid

Originator

Dicromil,Organol ,W. Germany,1981

Uses

A progestogen with low androgenic potency

Definition

ChEBI: Desogestrel is a 17beta-hydroxy steroid and a terminal acetylenic compound. It has a role as a contraceptive drug, a progestin and a synthetic oral contraceptive.

Manufacturing Process

A solution of 1.0 g of 11,11-methylene-18-methyl-delta4-estren-17-one in 33 ml tetrahydrofuran was added to a potassium-acetylide solution in tetrahydrofuran.
After 2 hours of stirring at 0°C to 5°C the reaction mixture was acidified with 2N H2SO4and processed further.
By a chromatographic treatment on silica gel and crystallization from pentane 0.7 g of 11,11-methylene-17α-ethynyl-18-methyl-δ4-estren-17β-ol with a melting point of 109°C to 110°C and an [α]D of +55°C (CHCl3) was obtained.

Therapeutic Function

Progestin

General Description

Desogestrel, (17α)-13-ethyl-11-methylene-18,19-dinorpregn-4-en-20-yn-17-ol, is a 19-nortestosterone analog with good progestin activity. Likethe other progestins, it is orally active and used in combinationwith an estrogen in oral contraceptives. Desogestrel is aprodrug that must be oxidized to the 3-one in vivo to haveprogestational action. CYPs 2C9 and 2C19 have been implicatedin the initial hydroxylation of desogestrel at C3.

Clinical Use

Desogestrel also is a prodrug and is rapidly metabolized in the intestinal mucosa and on first pass through the liver to its active metabolite, etonogestrel (3-ketodesogestrel). Following oral administration, the relative bioavailability for desogestrel is approximately 84%. Desogestrel also exhibits high selectivity for the progesterone receptor and low and rogenic activity, and it does not diminish the beneficial effects of estrogen on the lipid profile.

Desogestrel Preparation Products And Raw materials

Raw materials

ESTRONE(RG) 1,2-Ethanedithiol Sodium borohydride Ammonia

Preparation Products

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View Lastest Price from Desogestrel manufacturers

Sinoway Industrial co., ltd.
Product
Desogestrel 54024-22-5
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
20tons
Release date
2024-03-13
Shaanxi Dideu Medichem Co. Ltd
Product
Desogestrel 54024-22-5
Price
US $1.10/g
Min. Order
1g
Purity
99.0% min
Supply Ability
100 tons min
Release date
2021-05-26
Nantong Guangyuan Chemicl Co,Ltd
Product
Desogestrel 54024-22-5
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000kg
Release date
2023-11-01

54024-22-5, DesogestrelRelated Search:

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  • 13-ethyl-17-ethynyl-11-methylene-1,2,3,6,7,8,9,10,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-ol
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