Desogestrel
- Product Name
- Desogestrel
- CAS No.
- 54024-22-5
- Chemical Name
- Desogestrel
- Synonyms
- Desogestrel for system suitability CRS;Desogen;Desogestrel CRS;org2969;Cyclosa;Dicromil;DESTODENE;Cerazette;DESOGESTREL;DESOGESTRAL
- CBNumber
- CB2359630
- Molecular Formula
- C22H30O
- Formula Weight
- 310.47
- MOL File
- 54024-22-5.mol
Desogestrel Property
- Melting point:
- 109-110°C
- alpha
- D20 +55° (chloroform)
- Boiling point:
- 390.62°C (rough estimate)
- Density
- 1.0169 (rough estimate)
- refractive index
- 1.5100 (estimate)
- storage temp.
- -20°C Freezer
- solubility
- Practically insoluble in water, very soluble in methanol, freely soluble in anhydrous ethanol and in methylene chloride.
- pka
- 13.07±0.40(Predicted)
- form
- Solid
- color
- White to Almost white
- Merck
- 14,2926
Safety
- Safety Statements
- 24/25
- RIDADR
- UN 3077 9 / PGIII
- WGK Germany
- 3
- RTECS
- JF7975000
- HS Code
- 29372390
- Hazardous Substances Data
- 54024-22-5(Hazardous Substances Data)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P202Do not handle until all safety precautions have been read and understood.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313IF exposed or concerned: Get medical advice/attention.
P391Collect spillage. Hazardous to the aquatic environment
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 1173235
- Product name
- Desogestrel
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 100mg
- Price
- $436
- Updated
- 2024/03/01
- Product number
- 32809
- Product name
- Desogestrel
- Purity
- VETRANAL
- Packaging
- 25mg
- Price
- $164
- Updated
- 2022/05/15
- Product number
- 1173235
- Product name
- Desogestrel
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 50mg
- Price
- $452
- Updated
- 2022/05/15
- Product number
- D4163
- Product name
- Desogestrel
- Purity
- >98.0%(HPLC)
- Packaging
- 100mg
- Price
- $159
- Updated
- 2024/03/01
- Product number
- 23651
- Product name
- Desogestrel
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $61
- Updated
- 2024/03/01
Desogestrel Chemical Properties,Usage,Production
Description
Desogestrel is a synthetic progestogen. It inhibits ovulation and prevents fertilization in rabbits and mice. Desogestrel inhibits rhodamine 123 efflux, a measure of P-glycoprotein activity, ex vivo in human lymphocytes and CD8+ T cells in a dose-dependent manner. Formulations containing desogestrel have been used as oral contraceptives and for the treatment of polycystic ovary syndrome.
Chemical Properties
White Solid
Originator
Dicromil,Organol ,W. Germany,1981
Uses
A progestogen with low androgenic potency
Definition
ChEBI: Desogestrel is a 17beta-hydroxy steroid and a terminal acetylenic compound. It has a role as a contraceptive drug, a progestin and a synthetic oral contraceptive.
Manufacturing Process
A solution of 1.0 g of 11,11-methylene-18-methyl-delta4-estren-17-one in 33
ml tetrahydrofuran was added to a potassium-acetylide solution in
tetrahydrofuran.
After 2 hours of stirring at 0°C to 5°C the reaction mixture was acidified with
2N H2SO4and processed further.
By a chromatographic treatment on silica gel and crystallization from pentane
0.7 g of 11,11-methylene-17α-ethynyl-18-methyl-δ4-estren-17β-ol with a
melting point of 109°C to 110°C and an [α]D of +55°C (CHCl3) was obtained.
Therapeutic Function
Progestin
General Description
Desogestrel, (17α)-13-ethyl-11-methylene-18,19-dinorpregn-4-en-20-yn-17-ol, is a 19-nortestosterone analog with good progestin activity. Likethe other progestins, it is orally active and used in combinationwith an estrogen in oral contraceptives. Desogestrel is aprodrug that must be oxidized to the 3-one in vivo to haveprogestational action. CYPs 2C9 and 2C19 have been implicatedin the initial hydroxylation of desogestrel at C3.
Clinical Use
Desogestrel also is a prodrug and is rapidly metabolized in the intestinal mucosa and on first pass through the liver to its active metabolite, etonogestrel (3-ketodesogestrel). Following oral administration, the relative bioavailability for desogestrel is approximately 84%. Desogestrel also exhibits high selectivity for the progesterone receptor and low and rogenic activity, and it does not diminish the beneficial effects of estrogen on the lipid profile.
Desogestrel Preparation Products And Raw materials
Raw materials
Preparation Products
Desogestrel Suppliers
- Tel
- --
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- Country
- France
- ProdList
- 74
- Advantage
- 58
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- guedj.gregory@kleos-pharma.com
- Country
- France
- ProdList
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- Tel
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- webmestre-substances@ineris.fr
- Country
- France
- ProdList
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- Tel
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- Fax
- --
- orders@edqm.eu
- Country
- France
- ProdList
- 1913
- Advantage
- 81
View Lastest Price from Desogestrel manufacturers
- Product
- Desogestrel 54024-22-5
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 20tons
- Release date
- 2024-03-13
- Product
- Desogestrel 54024-22-5
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-26
- Product
- Desogestrel 54024-22-5
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1000kg
- Release date
- 2023-11-01