ChemicalBook > CAS DataBase List > Ipriflavone

Ipriflavone

Product Name
Ipriflavone
CAS No.
35212-22-7
Chemical Name
Ipriflavone
Synonyms
Ipriavone;Ipriflavon;7-ISOPROPOXYISOFLAVONE;Ipriflavone (Osteofix);tc80;osten;fl113;osteofix;YAMBOLAP;Iprosten
CBNumber
CB0698496
Molecular Formula
C18H16O3
Formula Weight
280.32
MOL File
35212-22-7.mol
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Ipriflavone Property

Melting point:
116-120 °C(lit.)
Boiling point:
363.04°C (rough estimate)
Density 
1.2170 (rough estimate)
refractive index 
1.4700 (estimate)
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMF:20.0(Max Conc. mg/mL);71.35(Max Conc. mM)
DMF:PBS (pH 7.2) (1:4):0.2(Max Conc. mg/mL);0.71(Max Conc. mM)
DMSO:33.11(Max Conc. mg/mL);118.11(Max Conc. mM)
Ethanol:1.5(Max Conc. mg/mL);5.35(Max Conc. mM)
form 
powder to crystal
color 
White to Almost white
Merck 
14,5074
InChI
InChI=1S/C18H16O3/c1-12(2)21-14-8-9-15-17(10-14)20-11-16(18(15)19)13-6-4-3-5-7-13/h3-12H,1-2H3
InChIKey
SFBODOKJTYAUCM-UHFFFAOYSA-N
SMILES
C1OC2=CC(OC(C)C)=CC=C2C(=O)C=1C1=CC=CC=C1
LogP
4.245 (est)
CAS DataBase Reference
35212-22-7(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
24/25-36/37/39-27-26
WGK Germany 
2
RTECS 
DJ3100500
HS Code 
29329990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
381551
Product name
7-Isopropoxy-3-phenyl-4H-1-benzopyran-4-one
Purity
97%
Packaging
5g
Price
$99.2
Updated
2024/03/01
Sigma-Aldrich
Product number
16499
Product name
Ipriflavone
Purity
analytical standard
Packaging
100mg
Price
$92
Updated
2022/05/15
TCI Chemical
Product number
I0669
Product name
Ipriflavone
Purity
>98.0%(GC)
Packaging
5g
Price
$47
Updated
2024/03/01
TCI Chemical
Product number
I0669
Product name
Ipriflavone
Purity
>98.0%(GC)
Packaging
25g
Price
$138
Updated
2024/03/01
Cayman Chemical
Product number
26319
Product name
Ipriflavone
Packaging
1mg
Price
$49
Updated
2024/03/01
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Ipriflavone Chemical Properties,Usage,Production

Description

Ipriflavone, a derivative of isoflavone, is a calcium metabolism regulator useful in the treatment of primary and secondary osteoporosis, as well as disorders of osteogenesis. It appears to be without significant side-effects.

Chemical Properties

white powder

Originator

Chinoin (Japan)

Uses

7-Isopropoxy-3-phenyl-4H-1-benzopyran-4-one (Ipriflavone) has been used as a model drug in a study to functionalize the mesoporous bioactive glasses (MBG). Study suggested that since ipriflavone is a hydrophobic anti-osteoporotic drug, it easily attaches to the surface of MBG and results in long-term drug delivery.

Uses

anabolic

Definition

ChEBI: Ipriflavone is a member of the class of isoflavones that is isoflavone in which the hydrogen at position 7 is replaced by an isopropoxy group. A synthetic isoflavone, it was formerly used for the treatment of osteoporosis, although a randomised controlled study failed to show any benefit. It is still used to prevent osteoporosis in post-menopausal women. It has a role as a bone density conservation agent. It is a member of isoflavones and an aromatic ether.

brand name

Osten

benefits

Ipriflavone is used clinically to treat osteoporosis. Bodybuilders also use ipriflavone, but enough experimental data supports this purpose. It has been shown to have anti-inflammatory and antioxidant activity. It helps to reduce bone loss, increase bone density, and reduce the risk of developing osteoporosis. It has also been found to help reduce neuroinflammation . In addition, it has been found to help reduce the risk of certain types of cancer, improve cognitive function and reduce the risk of depression.

General Description

7-Isopropoxy-3-phenyl-4H-1-benzopyran-4-one (Ipriflavone), a synthetic flavonoid, is reported to stimulate the activity of osteoblasts. It is reported to promote the deposition of calcium and the formation of mineralized nodules by newborn rat calvarial osteoblast-like (ROB) cells as well as the activity of alkaline phosphatase. Ipriflavone, an isoflavone derivative, is a new drug used to decrease bone loss in osteoporosis.

Side effects

Ipriflavone should be taken under medical supervision only. It can produce side effects such as stomach pain, diarrhoea, dizziness, etc. It may have a sudden increase in the WBC count if administered for six months or more. When the treatment with Ipriflavone is on, it is suggested that the WBC count should be monitored. 

in vitro

Ipriflavone inhibits the proliferation and DNA synthesis of MDA-231 cells and blocks the ligand-induced phosphorylation of Tyr(845) of the EGFR. Ipriflavone does not promote apoptosis of MDA-231 cells. Ipriflavone also promotes the deposition of calcium and the formation of mineralized nodules by newborn rat calvarial osteoblast-like cells as well as the activity of alkaline phosphatase.

in vivo

Ipriflavone ameliorated the host inflammatory response associated with activation of NLRP3 inflammasomes at the implantation site, which was characterised by inflammatory cell infiltration and reduced levels of the pro-inflammatory cytokine interleukin-1β. Daily oral administration of ipriflavone at 12 mg/mouse significantly inhibits the development of new osteolytic bone metastases and the progression of established osteolytic lesions, prolonging the life of tumor-bearing mice. Ipriflavone reduces the number of osteoclasts at the bone-cancer interface with no severe adverse effects on the host. 1-month treatment with ipriflavone increases bone density and improves the biomechanical properties of adult rat male bones without altering mineral composition.

Ipriflavone Preparation Products And Raw materials

Raw materials

2-Bromopropane Potassium carbonate Zinc chloride Resorcinol Benzeneacetonitrile Diethyl ether Acetic acid Phenylacetic acid

Preparation Products

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Ipriflavone Suppliers

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View Lastest Price from Ipriflavone manufacturers

Sinoway Industrial co., ltd.
Product
Ipriflavone 35212-22-7
Price
US $0.00-0.00/Kg/Bag
Min. Order
1Kg/Bag
Purity
0.99
Supply Ability
20 tons
Release date
2024-07-08
Jinan Million Pharmaceutical Co., Ltd
Product
Ipriflavone 35212-22-7
Price
US $1.00-1.00/kg
Min. Order
0.001kg
Purity
99.9%
Supply Ability
200 kg
Release date
2025-01-01
Wuhan Circle Star Chem-medical Technology Co.,Ltd
Product
Ipriflavone 35212-22-7
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98
Supply Ability
1000
Release date
2024-12-31

35212-22-7, IpriflavoneRelated Search:

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