3,5-Dichlorophenol Property

Melting point:

65-68 °C (lit.)

Boiling point:

233 °C (lit.)

Density 

1.3446 (rough estimate)

refractive index 

1.4430 (estimate)

Flash point:

233°C

storage temp. 

room temp

solubility 

Chloroform (Slightly), Ethyl Acetate (Slightly)

form 

Crystals, Crystalline Powder or Crystalline Mass

pka

pKa 8.48(H2O t=25 I=0.025) (Uncertain)

color 

Yellow to light brown

Water Solubility 

Slightly soluble in water. Very soluble in ethanol, ethyl ether and petroleum ether.

BRN 

1906458

CAS DataBase Reference

591-35-5(CAS DataBase Reference)

NIST Chemistry Reference

Phenol, 3,5-dichloro-(591-35-5)

EPA Substance Registry System

3,5-Dichlorophenol (591-35-5)

Safety

Hazard Codes 

Xn,Xi,T

Risk Statements 

22-36/38-36/37/38-23/24/25

Safety Statements 

26-28-37/39-45

RIDADR 

UN 2020 6.1/PG 3

WGK Germany 

3

RTECS 

SK8820000

Hazard Note 

Harmful

TSCA 

Yes

HazardClass 

6.1

PackingGroup 

III

HS Code 

29081990

Hazardous Substances Data

591-35-5(Hazardous Substances Data)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H311Toxic in contact with skin

H314Causes severe skin burns and eye damage

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

3,5-Dichlorophenol Chemical Properties,Usage,Production

Chemical Properties

yellow to light brown crystals, crystalline powder

Uses

3,5-Dichlorophenol is used as pharmaceutical intermediate.

Application

3,5-Dichlorophenol is a metabolite of the pesticides polychlorinated phenols and benzene hexachloride. found in chlorinated waste water; Used as a research chemical.

Preparation

Catalytic hydrodechlorination of polychlorophenols in organic or aqueous media with a palladium catalyst was used to obtain 3-chlorophenol and 3,5-dichlorophenol.

Definition

ChEBI: 3,5-dichlorophenol is a dichlorophenol in which the two chloro substituents are located at positions 3 and 5.

Synthesis Reference(s)

Tetrahedron Letters, 25, p. 4565, 1984 DOI: 10.1016/S0040-4039(01)81494-5

General Description

Prisms (from petroleum ether) or pink crystals.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

3,5-Dichlorophenol is incompatible with acid chlorides, acid anhydrides and oxidizing agents.

Fire Hazard

Flash point data for 3,5-Dichlorophenol are not available. 3,5-Dichlorophenol is probably combustible.

Purification Methods

Crystallise 3,5-dichlorophenol from pet ether/*benzene mixture and/or distil it. [Beilstein 6 IV 957.]