EXO1
- Product Name
- EXO1
- CAS No.
- 75541-83-2
- Chemical Name
- EXO1
- Synonyms
- EXO1;EOX 1;NSC 214045;EXOCYTIC INHIBITOR 1;4-FLUORO-BZ-2-ABZ-OME;2-(4-Fluoro-benzoylami;Exo 1 >=98% (HPLC), solid;Exo1 - CAS 75541-83-2 - Calbiochem;Exo1,inhibit,Exo-1,Exo 1,Inhibitor;Methyl 2-(4-fluorobenzamido)benzoate
- CBNumber
- CB0713355
- Molecular Formula
- C15H12FNO3
- Formula Weight
- 273.26
- MOL File
- 75541-83-2.mol
EXO1 Property
- storage temp.
- +2C to +8C
- solubility
- DMSO: 19 mg/mL, soluble
- form
- solid
- color
- White to off-white
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- E8280
- Product name
- Exo 1
- Purity
- ≥98% (HPLC), solid
- Packaging
- 5mg
- Price
- $69.3
- Updated
- 2024/03/01
- Product number
- 341220
- Product name
- Exo1
- Packaging
- 25mg
- Price
- $182
- Updated
- 2024/03/01
- Product number
- 18455
- Product name
- Exo 1
- Purity
- ≥99%
- Packaging
- 10mg
- Price
- $73
- Updated
- 2024/03/01
- Product number
- 18455
- Product name
- Exo 1
- Purity
- ≥99%
- Packaging
- 50mg
- Price
- $324
- Updated
- 2024/03/01
- Product number
- E8280
- Product name
- Exo 1
- Purity
- ≥98% (HPLC), solid
- Packaging
- 25mg
- Price
- $244
- Updated
- 2024/03/01
EXO1 Chemical Properties,Usage,Production
Uses
Exo1 is a cell-permeable, reversible inhibitor of exocytosis (IC50 = 20 μM). It interferes with protein trafficking and secretion mediated by the Golgi apparatus and endoplasmic reticulum by dissociating the GTPase activator ADP-ribosylation factor (ARF1) from Golgi membranes, which leads to a consequent collapse of the Golgi apparatus.
Uses
Exo 1 acts as a cell-permeable reverse inhibitor of exocytosis. Potential anti-inflammatory activity.
Uses
Exo 1 has been used as a component of the BRB80 buffer to study coat protein 1 (COPI)-mediated membrane trafficking. It has also been used as a Golgi inhibitor to study its effects on the long?interspersed?nuclear?element-1 (L1) retrotransposition.
Definition
ChEBI: 2-[[(4-fluorophenyl)-oxomethyl]amino]benzoic acid methyl ester is a member of benzamides.
Biochem/physiol Actions
Exo 1 is a cell-permeable methylanthranilate analog that promotes the release of adenosine diphosphate (ADP)-ribosylation factor (ARF) 1 from Golgi membranes. It also inhibits the membrane trafficking between the endoplasmic reticulum (ER) and the Golgi bodies.