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Coptisine chloride

Product Name
Coptisine chloride
CAS No.
6020-18-4
Chemical Name
Coptisine chloride
Synonyms
Q-100696;NSC-119754;Coptisine Hcl;Coptisin chloride;Coptisine choride;COPTISINE CHLORIDE;Coptisin chloride-RM;COPTISINE CHLORIDE(P);Coptisine Hydrochloride;COPTISINECHLORIDE(P)(PLEASECALL)
CBNumber
CB0718668
Molecular Formula
C19H14ClNO4
Formula Weight
355.77
MOL File
6020-18-4.mol
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Coptisine chloride Property

Melting point:
>258°C (dec.)
storage temp. 
Inert atmosphere,2-8°C
solubility 
DMSO (Slightly), Methanol (Slightly, Sonicated)
form 
Solid
color 
Orange to Dark Orange
Stability:
Hygroscopic
InChI
InChI=1S/C19H14NO4.ClH/c1-2-16-19(24-10-21-16)14-8-20-4-3-12-6-17-18(23-9-22-17)7-13(12)15(20)5-11(1)14;/h1-2,5-8H,3-4,9-10H2;1H/q+1;/p-1
InChIKey
LUXPUVKJHVUJAV-UHFFFAOYSA-M
SMILES
C12=CC3=C(C4OCOC=4C=C3)C=[N+]1CCC1C=C3OCOC3=CC2=1.[Cl-]
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H311Toxic in contact with skin

H330Fatal if inhaled

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P284Wear respiratory protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P310Immediately call a POISON CENTER or doctor/physician.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P314Get medical advice/attention if you feel unwell.

P320Specific treatment is urgent (see … on this label).

P321Specific treatment (see … on this label).

P322Specific measures (see …on this label).

P330Rinse mouth.

P361Remove/Take off immediately all contaminated clothing.

P363Wash contaminated clothing before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SMB00314
Product name
Coptisine Chloride
Purity
≥98% (HPLC)
Packaging
25MG
Price
$431
Updated
2025/07/31
Sigma-Aldrich
Product number
PHL89524
Product name
Coptisine chloride
Purity
phyproof? Reference Substance
Packaging
10MG
Price
$372
Updated
2025/07/31
Sigma-Aldrich
Product number
SMB00314
Product name
Coptisine Chloride
Purity
≥98% (HPLC)
Packaging
100MG
Price
$1370
Updated
2023/06/20
TCI Chemical
Product number
C3719
Product name
Coptisine Chloride
Packaging
25MG
Price
$181
Updated
2025/07/31
Cayman Chemical
Product number
28424
Product name
Coptisine (chloride)
Packaging
10mg
Price
$121
Updated
2024/03/01
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Coptisine chloride Chemical Properties,Usage,Production

Chemical Properties

Orange Brown Solid

Uses

Coptisine is an alkaloid found in Chinese goldthread (Coptis chinensis). A bacterial collagenase inhibitor. Coptisine has been found to reversibly inhibit Monoamine oxidase A in mice, pointing to a potential role as a natural antidepressant.

in vivo

Coptisine shows increased toxicity in mice in a concentration dependent manner, with LD50 value of 880.18 mg/kg. Coptisine (154 mg/kg/day, 90 days) shows no toxicity on SD rats. Coptisine (23.35, 46.7, 70.05 mg/kg, p.o.) dose-dependently decreases the levels of TC, TG, and LDL-c and increases HDL-c content in serum of hamsters to different degree, slows down weight gain induced by the HFHC diet, and raises the level of cholesterol and TBA in feces dose-dependently in hamsters. Coptisine (70.05 mg/kg, p.o.) suppresses HMGCR protein expression level and induces the protein expression of SREBP-2, LDLR, and CYP7A1 involved in cholesterol metabolism[2].

IC 50

IDO: 6.3 μM (IC50); IDO: 5.8 μM (Ki)

Coptisine chloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Coptisine chloride Suppliers

Canada 1 China 224 France 1 Germany 1 India 2 Japan 1 United Kingdom 2 United States 20 Global 252
cfm Oskar Tropitzsch
Tel
--
Fax
--
Country
Germany
ProdList
1136
Advantage
62
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View Lastest Price from Coptisine chloride manufacturers

Shanghai Standard Technology Co., Ltd.
Product
Coptisine chloride 6020-18-4
Price
US $0.00/mg
Min. Order
5mg
Purity
≥98%(HPLC)
Supply Ability
10 g
Release date
2019-12-02
Career Henan Chemical Co
Product
Coptisine chloride 6020-18-4
Price
US $1.00/kg
Min. Order
1g
Purity
99%
Supply Ability
100KG
Release date
2018-12-24

6020-18-4, Coptisine chlorideRelated Search:

Ferric chloride Polyvinyl chloride Sulfuryl chloride Choline chloride Aluminum chlorohydrate (-)-STYLOPINE Acetyl chloride Sodium chloride Calcium chloride Ammonium chloride Taxifolin PHELLODENDRINE CHLORIDE SINOMENINE HYDROCHLORIDE Potassium chloride Methylene Chloride COPTISINE 3-HYDROXYPHENETHYLAMINE HYDROCHLORIDE 1-Methylpyridinium chloride

  • 2,3,9,10-BISMETHYLENEDIOXYPROTOBERBERINE
  • COPTISINE CHLORIDE
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  • 7,8,13,13a-Tetradehydro-2,3:9,10-bis(methylenedioxy)berbinium chloride
  • Coptisine Hcl
  • Coptisine Hydrochloride
  • COPTISINECHLORIDE(P)(PLEASECALL)
  • 6,7-Dihydrobis[1,3]benzodioxolo[5,6-a:4',5'-g]quinoliziniuM Chloride
  • Coptisine chloride 7,8,13,13a-Tetradehydro-2,3:9,10-bis(methylenedioxy)berbinium chloride
  • Coptisin chloride
  • Coptisine chloride, 98%, from Coptis chinensis Franch.
  • NSC-119754
  • Q-100696
  • Coptisine choride
  • 6,7-Dihydro-[1,3]dioxolo[4',5':7,8]isoquinolino[3,2-a][1,3]dioxolo[4,5-g]isoquinolin-5-ium chloride
  • Coptisin chloride-RM
  • Coptisine chloride, 10 mM in DMSO
  • 6020-18-4
  • C19H14ClNO4
  • C19H14NO4Cl
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
  • chemical reagent
  • Amines
  • Heterocycles
  • Inhibitor
  • Intermediates & Fine Chemicals
  • Pharmaceuticals