COPTISINE

Product Name: COPTISINE
CAS No.: 3486-66-6
Chemical Name: COPTISINE
Synonyms: Coptisin;COPTISINE;COPTISINE(P);Coptisine Sulfate;2-Benzenedioic acid;COPTISINE USP/EP/BP;Coptisine, 10 mM in DMSO;Coptisine, 98%, from Coptis chinensis Franch.;6,7-Dihydrobis[1,3]benzodioxolo[5,6-a:4',5'-g]quinolizinium;Bis[1,3]benzodioxolo[5,6-a:4',5'-g]quinolizinium,6,7-dihydro-
CBNumber: CB7246829
Molecular Formula: C19H14NO4+
Formula Weight: 320.32
MOL File: 3486-66-6.mol

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COPTISINE Property

Melting point:: 212-217 °C
storage temp.: Store at 2-8°C
solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form: Powder

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Safety

Hazardous Substances Data: 3486-66-6(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Usbiological

Product number: 300099
Product name: Coptisine
Packaging: 20mg
Price: $575
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC73787
Product name: Coptisine
Packaging: 50mg
Price: $375
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb594640
Product name: Coptisine sulfate
Packaging: 20mg
Price: $499.8
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 73969
Product name: Coptisine
Purity: 98%
Packaging: 20mg
Price: $500
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: PXT0002161
Product name: COPTISINE
Purity: 95.00%
Packaging: 5MG
Price: $503.55
Updated: 2021/12/16

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COPTISINE Chemical Properties,Usage,Production

Chemical Properties

Very slightly soluble in water, slightly soluble in ethanol, soluble in alkali. Derived from the root of the poppy family plant celandine.

Uses

Coptisine is an alkaloid from Chinese goldthread, and acts as an efficient uncompetitive IDO inhibitor with a Ki value of 5.8 μM and an IC50 value of 6.3 μM.

Definition

ChEBI: A natural product found in Coptis japonica.

Hazard

A poison.

Safety Profile

A poison by ingestion. When heated to decomposition it emits toxic vapors of NOx.

in vivo

Coptisine shows increased toxicity in mice in a concentration dependent manner, with LD₅₀ value of 880.18 mg/kg. Coptisine (154 mg/kg/day, 90 days) shows no toxicity on SD rats. Coptisine (23.35, 46.7, 70.05 mg/kg, p.o.) dose-dependently decreases the levels of TC, TG, and LDL-c and increases HDL-c content in serum of hamsters to different degree, slows down weight gain induced by the HFHC diet, and raises the level of cholesterol and TBA in feces dose-dependently in hamsters. Coptisine (70.05 mg/kg, p.o.) suppresses HMGCR protein expression level and induces the protein expression of SREBP-2, LDLR, and CYP7A1 involved in cholesterol metabolism^[2].

IC 50

IDO: 6.3 μM (IC₅₀); IDO: 5.8 μM (Ki)

References

[1] Yu D, et al. The IDO inhibitor coptisine ameliorates cognitive impairment in a mouse model of Alzheimer's disease. J Alzheimers Dis. 2015;43(1):291-302. DOI:10.3233/JAD-140414
[2] He K, et al. The safety and anti-hypercholesterolemic effect of coptisine in Syrian golden hamsters. Lipids. 2015 Feb;50(2):185-94. DOI:10.1007/s11745-014-3983-7
[3] Rao PC, et al. Coptisine-induced cell cycle arrest at G2/M phase and reactive oxygen species-dependent mitochondria-mediated apoptosis in non-small-cell lung cancer A549 cells. Tumour Biol. 2017 Mar;39(3):1010428317694565. DOI:10.1177/1010428317694565

COPTISINE Preparation Products And Raw materials

Raw materials

Preparation Products

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COPTISINE Suppliers

China 162 Germany 4 India 1 United Kingdom 3 United States 18 Global 188

Beijing Ouhe Technology Co., Ltd

Tel: 010-010-82967028 13522913783
Fax: +86-10-82967029
Email: 2355560935@qq.com
Country: China
ProdList: 12000
Advantage: 60

Sichuan Kulinan Technology Co., Ltd

Tel: 400-1166-196 18981987031
Fax: 028-84555506 800101999
Email: cdhxsj@163.com
Country: China
ProdList: 11705
Advantage: 57

Shenzhen Sungening Bio-Tech Co., Ltd

Tel: +86-0755-89668383
Fax: +86-0755-89594066/4038
Email: sales@sungening.com
Country: China
ProdList: 1319
Advantage: 65

ShangHai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847 13636370518
Fax: 021-55068248
Email: shyysw007@163.com
Country: China
ProdList: 4999
Advantage: 60

Chengdu Ai Keda Chemical Technology Co., Ltd.

Tel: 4008-755-333 18080918076
Fax: 028-86757656
Email: 800078821@qq.com
Country: China
ProdList: 9718
Advantage: 55

Chengdu Biopurify Phytochemicals Ltd.

Tel: +86-028-82633397 18982077548
Fax: +86-28-82633165
Email: cwb1@biopurify.cn
Country: China
ProdList: 2376
Advantage: 60

Chengdu Climax Biotech Co., Ltd.

Tel: 028-83311324 1278112614
Fax: 028-83311324
Email: climaxbiotech@gmail.com
Country: China
ProdList: 925
Advantage: 58

Shanghai Winherb Medical Technology Co., Ltd.

Tel: 021-38218169 13341702378
Fax: QQ：190129269
Email: winherb@126.com
Country: China
ProdList: 1245
Advantage: 58

Beijing HuaMeiHuLiBiological Chemical

Tel: 010-56205725
Fax: 010-65763397
Email: waley188@sohu.com
Country: China
ProdList: 12335
Advantage: 58

Shanghai Ruji Biology Technology Co., Ltd.

Tel: +86-21-65211385-8001 36031160
Fax: +86-21-65211385-8004
Email: sales@shruji.com
Country: China
ProdList: 3224
Advantage: 55

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View Lastest Price from COPTISINE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Coptisine 3486-66-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 20T
Release date: 2024-07-10

Baoji Guokang Healthchem co.,ltd

Product: COPTISINE 3486-66-6
Price: US $630.00/G
Min. Order: 1G
Purity: 98%
Supply Ability: 100kgs
Release date: 2021-06-07

Career Henan Chemical Co

Product: COPTISINE 3486-66-6
Price: US $2.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 10000kg
Release date: 2018-08-10

3486-66-6, COPTISINERelated Search:

Cevadine veratramine daurisoline 2-[2-(Methylamino)benzoyl]-3,4-dihydro-β-carboline-1(2H)-one VERATRIDINE L-Hyoscyamine Worenine menisdaurin Xanthiazone Tetrahydroepiberberine, Sinactine 5,6-Dihydro-2,3-(methylenedioxy)-9,10-dimethoxy-13-methyldibenzo[a,g]quinolizinium Daurinoline Xanthiside epiberberine (-)-STYLOPINE COPTISINE COPTISINE CHLORIDE,COPTISINE CHLORIDE(P) COPTISINE CHLORIDE(RG)

COPTISINE

Coptisin

5,6-Dihydro-2,3:9,10-bis(methylenedioxy)dibenzo[a,g]quinolizinium

6,7-Dihydrobis[1,3]benzodioxolo[5,6-a:4',5'-g]quinolizinium

Coptisine Sulfate

Coptisine, 98%, from Coptis chinensis Franch.

COPTISINE(P)

Bis[1,3]benzodioxolo[5,6-a:4',5'-g]quinolizinium,6,7-dihydro-

COPTISINE USP/EP/BP

2-Benzenedioic acid

6,7-Dihydro-[1,3]dioxolo[4',5':7,8]isoquinolino[3,2-a][1,3]dioxolo[4,5-g]isoquinolin-5-ium

Coptisine, 10 mM in DMSO

3486-66-6

C19H14NO4

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract

Alkaloids