ChemicalBook > CAS DataBase List > COPTISINE

COPTISINE

Product Name: COPTISINE
CAS No.: 3486-66-6
Chemical Name: COPTISINE
Synonyms: Coptisin;COPTISINE;COPTISINE(P);Coptisine Sulfate;2-Benzenedioic acid;COPTISINE USP/EP/BP;Coptisine, 10 mM in DMSO;Coptisine, 98%, from Coptis chinensis Franch.;6,7-Dihydrobis[1,3]benzodioxolo[5,6-a:4',5'-g]quinolizinium;Bis[1,3]benzodioxolo[5,6-a:4',5'-g]quinolizinium,6,7-dihydro-
CBNumber: CB7246829
Molecular Formula: C19H14NO4+
Formula Weight: 320.32
MOL File: 3486-66-6.mol

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COPTISINE Property

Melting point:: 212-217 °C
storage temp.: Store at 2-8°C
solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form: Powder

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Safety

Hazardous Substances Data: 3486-66-6(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Usbiological

Product number: 300099
Product name: Coptisine
Packaging: 20mg
Price: $575
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC73787
Product name: Coptisine
Packaging: 5mg
Price: $75
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC73787
Product name: Coptisine
Packaging: 10mg
Price: $120
Updated: 2021/12/16

ApexBio Technology

Product number: N1737
Product name: Coptisine
Packaging: 20mg
Price: $200
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC73787
Product name: Coptisine
Packaging: 25mg
Price: $250
Updated: 2021/12/16

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COPTISINE Chemical Properties,Usage,Production

Chemical Properties

Very slightly soluble in water, slightly soluble in ethanol, soluble in alkali. Derived from the root of the poppy family plant celandine.

Uses

Coptisine is an alkaloid from Chinese goldthread, and acts as an efficient uncompetitive IDO inhibitor with a Ki value of 5.8 μM and an IC50 value of 6.3 μM.

Definition

ChEBI: A natural product found in Coptis japonica.

Hazard

A poison.

Safety Profile

A poison by ingestion. When heated to decomposition it emits toxic vapors of NOx.

in vivo

Coptisine shows increased toxicity in mice in a concentration dependent manner, with LD₅₀ value of 880.18 mg/kg. Coptisine (154 mg/kg/day, 90 days) shows no toxicity on SD rats. Coptisine (23.35, 46.7, 70.05 mg/kg, p.o.) dose-dependently decreases the levels of TC, TG, and LDL-c and increases HDL-c content in serum of hamsters to different degree, slows down weight gain induced by the HFHC diet, and raises the level of cholesterol and TBA in feces dose-dependently in hamsters. Coptisine (70.05 mg/kg, p.o.) suppresses HMGCR protein expression level and induces the protein expression of SREBP-2, LDLR, and CYP7A1 involved in cholesterol metabolism^[2].

IC 50

IDO: 6.3 μM (IC₅₀); IDO: 5.8 μM (Ki)

References

[1] Yu D, et al. The IDO inhibitor coptisine ameliorates cognitive impairment in a mouse model of Alzheimer's disease. J Alzheimers Dis. 2015;43(1):291-302. DOI:10.3233/JAD-140414
[2] He K, et al. The safety and anti-hypercholesterolemic effect of coptisine in Syrian golden hamsters. Lipids. 2015 Feb;50(2):185-94. DOI:10.1007/s11745-014-3983-7
[3] Rao PC, et al. Coptisine-induced cell cycle arrest at G2/M phase and reactive oxygen species-dependent mitochondria-mediated apoptosis in non-small-cell lung cancer A549 cells. Tumour Biol. 2017 Mar;39(3):1010428317694565. DOI:10.1177/1010428317694565

COPTISINE Preparation Products And Raw materials

Raw materials

Preparation Products

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COPTISINE Suppliers

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View Lastest Price from COPTISINE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Coptisine 3486-66-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 20T
Release date: 2024-07-10

Baoji Guokang Healthchem co.,ltd

Product: COPTISINE 3486-66-6
Price: US $630.00/G
Min. Order: 1G
Purity: 98%
Supply Ability: 100kgs
Release date: 2021-06-07

Career Henan Chemical Co

Product: COPTISINE 3486-66-6
Price: US $2.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 10000kg
Release date: 2018-08-10

3486-66-6, COPTISINERelated Search:

Cevadine veratramine daurisoline 2-[2-(Methylamino)benzoyl]-3,4-dihydro-β-carboline-1(2H)-one VERATRIDINE L-Hyoscyamine Worenine menisdaurin Xanthiazone Tetrahydroepiberberine, Sinactine 5,6-Dihydro-2,3-(methylenedioxy)-9,10-dimethoxy-13-methyldibenzo[a,g]quinolizinium Daurinoline Xanthiside epiberberine (-)-STYLOPINE COPTISINE COPTISINE CHLORIDE,COPTISINE CHLORIDE(P) COPTISINE CHLORIDE(RG)

COPTISINE

Coptisin

5,6-Dihydro-2,3:9,10-bis(methylenedioxy)dibenzo[a,g]quinolizinium

6,7-Dihydrobis[1,3]benzodioxolo[5,6-a:4',5'-g]quinolizinium

Coptisine Sulfate

Coptisine, 98%, from Coptis chinensis Franch.

COPTISINE(P)

Bis[1,3]benzodioxolo[5,6-a:4',5'-g]quinolizinium,6,7-dihydro-

COPTISINE USP/EP/BP

2-Benzenedioic acid

6,7-Dihydro-[1,3]dioxolo[4',5':7,8]isoquinolino[3,2-a][1,3]dioxolo[4,5-g]isoquinolin-5-ium

Coptisine, 10 mM in DMSO

3486-66-6

C19H14NO4

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract

Alkaloids