ChemicalBook > CAS DataBase List > 4-(Trifluoromethyl)nicotinic acid

4-(Trifluoromethyl)nicotinic acid

Product Name
4-(Trifluoromethyl)nicotinic acid
CAS No.
158063-66-2
Chemical Name
4-(Trifluoromethyl)nicotinic acid
Synonyms
TFNA;4-(TRIFLUOROMETHYL)PYRIDINE-3-CARBOXYLIC ACID;TFNA Standard;BUTTPARK 43\57-42;RARECHEM AL BO 0760;TFNA 100 μg/ml Acetonitrile;TFNA (flonicamid metabolite);4-(Trifluromethyl)nicotinic acid;-(Trifluoromethyl)nicotinic acid;4-(TRIFLUOROMETHYL)NICOTINIC ACID
CBNumber
CB0722311
Molecular Formula
C7H4F3NO2
Formula Weight
191.11
MOL File
158063-66-2.mol
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4-(Trifluoromethyl)nicotinic acid Property

Melting point:
146-148 °C(lit.)
Boiling point:
290.4±40.0 °C(Predicted)
Density 
1.484±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly)
pka
2.50±0.36(Predicted)
form 
Solid
color 
Pale Yellow to Dark Yellow
InChIKey
LMRJHNFECNKDKH-UHFFFAOYSA-N
CAS DataBase Reference
158063-66-2(CAS DataBase Reference)
EPA Substance Registry System
3-Pyridinecarboxylic acid, 4-(trifluoromethyl)- (158063-66-2)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-37/39
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
518697
Product name
4-(Trifluoromethyl)pyridine-3-carboxylic acid
Purity
98%
Packaging
1g
Price
$74.1
Updated
2024/03/01
TCI Chemical
Product number
T2742
Product name
4-(Trifluoromethyl)nicotinic Acid
Packaging
1G
Price
$45
Updated
2024/03/01
TCI Chemical
Product number
T2742
Product name
4-(Trifluoromethyl)nicotinic Acid
Packaging
5G
Price
$177
Updated
2024/03/01
Alfa Aesar
Product number
L19553
Product name
4-(Trifluoromethyl)nicotinic acid, 98%
Packaging
250mg
Price
$68.65
Updated
2024/03/01
Alfa Aesar
Product number
L19553
Product name
4-(Trifluoromethyl)nicotinic acid, 98%
Packaging
1g
Price
$126.65
Updated
2024/03/01
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4-(Trifluoromethyl)nicotinic acid Chemical Properties,Usage,Production

Uses

4-(Trifluoromethyl)-3-Pyridinecarboxylic Acid is a useful synthetic intermediate. It can be used to prepare pyridine carboxamides as palm site inhibitors of HCV NS5B polymerase. It can also be used to synthesize pyrazolylcarboxanilides as Ca2+ release-activated Ca2+ (CRAC) channel inhibitors.

Application

4-(Trifluoromethyl)nicotinic acid is a trifluoromethyl-containing aromatic compound with unique biological activity, which can be used as a precursor material for the preparation of other pesticides or medicines. 4-(Trifluoromethyl)nicotinic acid is a key intermediate of flonicamid, a highly effective insecticide.

Preparation

synthesis of 4-(Trifluoromethyl)nicotinic acid: add 5g (0.0192mol) Methyl 2,6-dichloro-4-(trifluoromethyl)nicotinate in turn to a 100mL three-necked flask, 0.3g of 10% Pd/C (water content 63.45%) ), 5.25g (0.0389mol) CH3COONa 3H2O and 20mL ethanol, after stirring and dissolving, nitrogen was replaced 3 times to discharge air, after hydrogen replacement 2 times, the reaction was stirred at room temperature for 8h under a hydrogen atmosphere until no hydrogen was absorbed to complete the reaction, and suction filtration was recovered. Palladium carbon, washed the filter cake 3 times with ethanol, the filtrate was rotary evaporated to remove the solvent, added 20 mL of water to the obtained solid, fully shaken to dissolve it, added hydrochloric acid to adjust pH=2～3, extracted 3 times with ethyl acetate, The organic phases were combined and washed three times with saturated brine, dried over anhydrous sodium sulfate, and rotary-evaporated to obtain 3.3 g of a pale yellow solid with a yield of 90.4%.

Definition

ChEBI: 4-(trifluoromethyl)nicotinic acid is a member of pyridines and an aromatic carboxylic acid.

4-(Trifluoromethyl)nicotinic acid Preparation Products And Raw materials

Raw materials

PALLADIUM, 10% ON CHARCOAL (Trifluoromethyl)trimethylsilane Nitrogen N-Methyl-2-pyrrolidone Ammonium formate Cuprous iodide Potassium fluoride Carbon dioxide Diisopropylamine Tetrahydrofuran Methanol n-Butyllithium 2-Chloro-4-iodopyridine

Preparation Products

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View Lastest Price from 4-(Trifluoromethyl)nicotinic acid manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
4-(Trifluoromethyl)nicotinic acid 158063-66-2
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2023-04-27
PNP Biotech Co. Ltd
Product
4-(Trifluoromethyl)nicotinic acid 158063-66-2
Price
US $0.00/kg
Min. Order
25kg
Purity
98%
Supply Ability
Inquiry
Release date
2023-07-12
Wuhan Boye Science And Technology Development Co., Ltd.
Product
4-(Trifluoromethyl)nicotinic acid 158063-66-2
Price
US $0.00/Kg/Drum
Min. Order
1Kg/Drum
Purity
98%
Supply Ability
100tons
Release date
2021-03-25

158063-66-2, 4-(Trifluoromethyl)nicotinic acidRelated Search:

Chromium picolinate 2-Chloro-4-(trifluoromethyl)pyridine Zinc picolinate 2-(Trifluoromethyl)pyridine Lithium trifluoromethanesulfonate 3-Picoline Benzotrifluoride 2-Picolinic acid 4-Trifluoromethylbenzyl chloride 3-(Trifluoromethyl)benzaldehyde Pyridine 4-(Trifluoromethyl)pyridine 3-Trifluoromethylpyridine (Trifluoromethyl)trimethylsilane 4-Aminobenzotrifluoride 3-(Trifluoromethyl)cinnamic acid Nicotinic acid Trifluoromethanesulfonic acid

  • 4-(Trifluoromethyl)pyridine-3-carboxylic acid, 3-Carboxy-4-(trifluoromethyl)pyridine
  • FlonicaMide Metabolite (TFNA type, 4-TriuoroMethyl nicotinic acid)
  • TFNA (flonicamid metabolite)
  • 4-(TrifluoroMethyl)-3-Pyridinecarboxylic Acid
  • 3-Pyridinecarboxylic acid, 4-(trifluoromethyl)-
  • 4-(Trifluoromethyl)pyridine-3-carboxylic acid 98%
  • 4-(Trifluoromethyl)pyridine-3-carboxylic acid, >=98%
  • 4-(TRIFLUOROMETHYL)NICOTINIC ACID
  • 4-(TRIFLUOROMETHYL)PYRIDINE-3-CARBOXYLIC ACID
  • BUTTPARK 43\57-42
  • 4-(Trifluoromethyl)nicotinic acid 98%
  • 4-(Trifluoromethyl)nicotinicacid98%
  • RARECHEM AL BO 0760
  • 4-(Trifluromethyl)nicotinic acid
  • TFNA
  • TFNA Standard
  • -(Trifluoromethyl)nicotinic acid
  • 4-(Trifluoromethyl)nicotinic acid ISO 9001：2015 REACH
  • 4-Trifluoromethylpyridin-3-carboxylic acid
  • 4- (trifluoromethyl) hydrochloric acid
  • TFNA 100 μg/ml Acetonitrile
  • 158063-66-2
  • ARYL ACID
  • Building Blocks
  • C7 and C8
  • Heterocyclic Building Blocks
  • Pyridines
  • Fluorine series
  • Building Blocks
  • C6 to C7
  • Chemical Synthesis
  • Heterocyclic Building Blocks
  • Carboxylic Acids
  • Pyridines
  • Carboxylic Acids
  • Nitrogen cyclic compounds
  • Pyridine Series