ChemicalBook > CAS DataBase List > A 61603 HYDROBROMIDE

A 61603 HYDROBROMIDE

Product Name
A 61603 HYDROBROMIDE
CAS No.
107756-30-9
Chemical Name
A 61603 HYDROBROMIDE
Synonyms
A 61603;A 61603 HYDROBROMIDE;A 61603, alpha1A-adrenoceptor agonist;N-[5-(4,5-DIHYDRO-1H-IMIDAZOL-2-YL)-2-HYDROXY-5,6,7,8-TETRAHYDRONAPHTHALEN-1-YL]METHANESULFONAMIDE HYDROBROMIDE;N-(5-(4,5-Dihydro-(1H)-imidazol-2-yl)-2-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl)methanesulfonamidehydrobromide;N-[5-(4,5-dihydro-1H-imidazol-2-yl)-5,6,7,8-tetrahydro-2-hydroxy-1-naphthalenyl]-methanesulfonamide, monohydrobromide
CBNumber
CB0723691
Molecular Formula
C14H20BrN3O3S
Formula Weight
390.3
MOL File
107756-30-9.mol
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A 61603 HYDROBROMIDE Property

storage temp. 
Desiccate at +4°C
solubility 
Soluble in H2O
form 
crystalline solid
color 
White to off-white
Water Solubility 
Soluble to 50 mM in water
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
17358
Product name
A-61603
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
17358
Product name
A-61603
Purity
≥98%
Packaging
5mg
Price
$100
Updated
2024/03/01
Cayman Chemical
Product number
17358
Product name
A-61603
Purity
≥98%
Packaging
10mg
Price
$139
Updated
2024/03/01
Tocris
Product number
1052
Product name
A61603hydrobromide
Packaging
10
Price
$195
Updated
2021/12/16
Tocris
Product number
1052
Product name
A61603hydrobromide
Packaging
50
Price
$818
Updated
2021/12/16
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A 61603 HYDROBROMIDE Chemical Properties,Usage,Production

Uses

A 61603 is a selective α1A-adrenergic receptor agonist.

Biological Activity

Potent α -adrenoceptor agonist that is at least 35-fold more potent at α 1A than at α 1B or α 1D sites. Induces dose response increases in spontaneous Ca 2+ transients in rat ventricular myocytes in vitro (EC 50 = 6.9 nmol/L). Also available as part of the α 1 -Adrenoceptor Tocriset™ .

IC 50

α1A-adrenergic receptor

storage

Desiccate at +4°C

References

[1]. knepper sm, buckner sa, brune me, et al. a-61603, a potent alpha 1-adrenergic receptor agonist, selective for the alpha 1a receptor subtype. j pharmacol exp ther, 1995, 274(1): 97-103.
[2]. meyer md, altenbach rj, hancock aa, et al. synthesis and in vitro characterization of n-[5-(4,5-dihydro-1h-imidazol-2-yl)-2-hydroxy-5,6,7,8- tetrahydronaphthalen-1-yl]methanesulfonamide and its enantiomers: a novel selective alpha 1a receptor agonist. j med chem, 1996, 39(20): 4116-4119.
[3]. luo dl, gao j, fan ll, et al. receptor subtype involved in alpha 1-adrenergic receptor-mediated ca2+ signaling in cardiomyocytes. acta pharmacol sin, 2007, 28(7): 968-974.
[4]. martínez-salas sg1, campos-peralta jm, pares-hipolito j, et al. alpha1a-adrenoceptors predominate in the control of blood pressure in mouse mesenteric vascular bed. auton autacoid pharmacol, 2007, 27(3): 137-142.

A 61603 HYDROBROMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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A 61603 HYDROBROMIDE Suppliers

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107756-30-9, A 61603 HYDROBROMIDERelated Search:

Citalopram hydrobromide Methanesulfonamide Tetryzoline 1,2,3,4-TETRAHYDRONAPHTHALEN-1-YLMETHYLAMINE A 61603 HYDROBROMIDE 5,6,7,8-Tetrahydro-1-naphthylamine

  • N-[5-(4,5-DIHYDRO-1H-IMIDAZOL-2-YL)-2-HYDROXY-5,6,7,8-TETRAHYDRONAPHTHALEN-1-YL]METHANESULFONAMIDE HYDROBROMIDE
  • N-(5-(4,5-Dihydro-(1H)-imidazol-2-yl)-2-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl)methanesulfonamidehydrobromide
  • A 61603 HYDROBROMIDE
  • A 61603
  • A 61603, alpha1A-adrenoceptor agonist
  • N-[5-(4,5-dihydro-1H-imidazol-2-yl)-5,6,7,8-tetrahydro-2-hydroxy-1-naphthalenyl]-methanesulfonamide, monohydrobromide
  • 107756-30-9
  • C14H20BRN3O3S
  • C14H19N3O3SHBr