A 61603 HYDROBROMIDE
- Product Name
- A 61603 HYDROBROMIDE
- CAS No.
- 107756-30-9
- Chemical Name
- A 61603 HYDROBROMIDE
- Synonyms
- A 61603;A 61603 HYDROBROMIDE;N-[5-(4,5-DIHYDRO-1H-IMIDAZOL-2-YL)-2-HYDROXY-5,6,7,8-TETRAHYDRONAPHTHALEN-1-YL]METHANESULFONAMIDE HYDROBROMIDE;N-(5-(4,5-Dihydro-(1H)-imidazol-2-yl)-2-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl)methanesulfonamidehydrobromide
- CBNumber
- CB0723691
- Molecular Formula
- C14H20BrN3O3S
- Formula Weight
- 390.3
- MOL File
- 107756-30-9.mol
A 61603 HYDROBROMIDE Property
- storage temp.
- Desiccate at +4°C
- solubility
- Soluble in H2O
- form
- crystalline solid
- Water Solubility
- Soluble to 50 mM in water
N-Bromosuccinimide Price
- Product number
- 17358
- Product name
- A-61603
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 17358
- Product name
- A-61603
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $100
- Updated
- 2024/03/01
- Product number
- 17358
- Product name
- A-61603
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $139
- Updated
- 2024/03/01
- Product number
- 1052
- Product name
- A61603hydrobromide
- Packaging
- 10
- Price
- $195
- Updated
- 2021/12/16
- Product number
- 1052
- Product name
- A61603hydrobromide
- Packaging
- 50
- Price
- $818
- Updated
- 2021/12/16
A 61603 HYDROBROMIDE Chemical Properties,Usage,Production
Uses
A 61603 is a selective α1A-adrenergic receptor agonist.
Biological Activity
Potent α -adrenoceptor agonist that is at least 35-fold more potent at α 1A than at α 1B or α 1D sites. Induces dose response increases in spontaneous Ca 2+ transients in rat ventricular myocytes in vitro (EC 50 = 6.9 nmol/L). Also available as part of the α 1 -Adrenoceptor Tocriset™ .
storage
Desiccate at +4°C
References
[1]. knepper sm, buckner sa, brune me, et al. a-61603, a potent alpha 1-adrenergic receptor agonist, selective for the alpha 1a receptor subtype. j pharmacol exp ther, 1995, 274(1): 97-103.
[2]. meyer md, altenbach rj, hancock aa, et al. synthesis and in vitro characterization of n-[5-(4,5-dihydro-1h-imidazol-2-yl)-2-hydroxy-5,6,7,8- tetrahydronaphthalen-1-yl]methanesulfonamide and its enantiomers: a novel selective alpha 1a receptor agonist. j med chem, 1996, 39(20): 4116-4119.
[3]. luo dl, gao j, fan ll, et al. receptor subtype involved in alpha 1-adrenergic receptor-mediated ca2+ signaling in cardiomyocytes. acta pharmacol sin, 2007, 28(7): 968-974.
[4]. martínez-salas sg1, campos-peralta jm, pares-hipolito j, et al. alpha1a-adrenoceptors predominate in the control of blood pressure in mouse mesenteric vascular bed. auton autacoid pharmacol, 2007, 27(3): 137-142.