Procaine penicillin G
- Product Name
- Procaine penicillin G
- CAS No.
- 54-35-3
- Chemical Name
- Procaine penicillin G
- Synonyms
- PENICILLIN G PROCAINE;PROCAINE BENZYLPENICILLIN;benzylpenicillin procaine;duphapen;depocillin;hostacillin;hydracillin;rocaine penicillin;Procain-Penicillin;Procain Penicillin G
- CBNumber
- CB0731029
- Molecular Formula
- C29H38N4O6S
- Formula Weight
- 570.7
- MOL File
- 54-35-3.mol
Procaine penicillin G Property
- Melting point:
- 129-130 °C
- Density
- 1.1335 (rough estimate)
- refractive index
- 1.6000 (estimate)
- storage temp.
- Store at -20°C
- solubility
- DMSO: 100 mg/mL (175.22 mM);Ethanol: 20 mg/mL (35.04 mM)
- Water Solubility
- Water: 10 mg/mL (17.52 mM)
- CAS DataBase Reference
- 54-35-3
- EPA Substance Registry System
- 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-[(phenylacetyl)amino]- (2S,5R,6R)-, compd. with 2-(diethylamino)ethyl 4-aminobenzoate (1:1) (54-35-3)
Safety
- Toxicity
- LD50 orl-rat: >2 g/kg ABANAE 3,534,55/56
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- O634
- Product name
- ProcainepenicillinG
- Packaging
- 100mg
- Price
- $89
- Updated
- 2021/12/16
- Product number
- API0027913
- Product name
- PROCAINE BENZYL PENICILLIN
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $458.16
- Updated
- 2021/12/16
Procaine penicillin G Chemical Properties,Usage,Production
Chemical Properties
White, fine crystals or powder; odorless; relatively stable to air and light; solutions dextroro- tatory. Sparingly soluble in water; slightly soluble in alcohol; fairly soluble in chloroform.
Originator
Duracillin,Lilly,US,1948
Uses
Antibacterial.
Manufacturing Process
There was added to 250 ml of a concentrated butyl acetate extract containing 74,000 units of the acid form of penicillin per ml, 50 ml of a butyl acetate solution containing 0.238 g per ml of procaine base. The solution was agitated for one hour. The precipitate which formed was very gummy and not in the form of discrete crystals. This precipitate was crystallized by scratching the side of the vessel and agitating further. After this treatment 18.25 g of crystalline procaine penicillin was obtained which assayed 1010 units per mg representing a yield of 99.6% of the activity contained in the concentrated extract.
brand name
Duracillin(Lilly); Pfizerpen (Pfizer).
Therapeutic Function
Antibacterial
General Description
The first widely used amine salt of penicillin G wasmade with procaine. Penicillin G procaine (Crysticillin,Duracillin, Wycillin) can be made readily from penicillin Gsodium by treatment with procaine hydrochloride. This saltis considerably less soluble in water than the alkali metalsalts, requiring about 250 mL to dissolve 1 g. Free penicillinis released only as the compound dissolves and dissociates.It has an activity of 1,009 units/mg. A large number ofpreparations for injection of penicillin G procaine are commerciallyavailable. Most of these are either suspensions inwater to which a suitable dispersing or suspending agent, a buffer, and a preservative have been added or suspensions inpeanut oil or sesame oil that have been gelled by theaddition of 2% aluminum monostearate. Some commercialproducts are mixtures of penicillin G potassium or sodiumwith penicillin G procaine; the water-soluble salt providesrapid development of a high plasma concentration of penicillin,and the insoluble salt prolongs the duration of effect.
Safety Profile
Moderately toxic by intraperitoneal and intramuscular routes. Slightly toxic by ingestion and subcutaneous routes. When heated to decomposition it emits toxic vapors of NOx, and SOx.
Procaine penicillin G Preparation Products And Raw materials
Raw materials
Preparation Products
Procaine penicillin G Suppliers
- Tel
- (0311)83098230/83098186
- Fax
- (0311)83098198
- Country
- China
- ProdList
- 13
- Advantage
- 60
- Tel
- 15527768850
- 1791901229@qq.com
- Country
- China
- ProdList
- 8836
- Advantage
- 52
- Tel
- 027-59207852 13308628970
- Fax
- QQ3130921841
- buy@fortunachem.com
- Country
- China
- ProdList
- 2866
- Advantage
- 58
- Tel
- 021-021-33632979 15002134094
- Fax
- 021-33632979
- marketing@targetmol.com
- Country
- China
- ProdList
- 7783
- Advantage
- 58
- Tel
- 18149758185 18149758185
- sales-cpd@caerulumpharma.com
- Country
- China
- ProdList
- 3466
- Advantage
- 58
- Tel
- 27-81302488 18007166089
- Fax
- 027-81302088
- info@dkybpc.com
- Country
- China
- ProdList
- 2024
- Advantage
- 58
- Tel
- 13971561712, 13995564702, 027-50664929
- Fax
- 027-50664927
- hbeixys2001@163.com
- Country
- China
- ProdList
- 3120
- Advantage
- 55
- Tel
- 027-59262863 13277907145 3091977954
- Fax
- 027-59420980
- Country
- China
- ProdList
- 4943
- Advantage
- 58
- Tel
- 16314854226
- info@bocsci.com
- Country
- United States
- ProdList
- 9923
- Advantage
- 65
- Tel
- 86 512-62572107 62962707
- Fax
- 86 512-62922078
- Country
- China
- ProdList
- 800
- Advantage
- 58
View Lastest Price from Procaine penicillin G manufacturers
- Product
- Procaine penicillin G 54-35-3
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 50000kg
- Release date
- 2023-11-21
- Product
- Procaine Benzylpenicillin 54-35-3
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20tons
- Release date
- 2024-04-29
- Product
- Procaine Penicillin G 54-35-3
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000kg
- Release date
- 2024-04-24