ChemicalBook > CAS DataBase List > Procaine penicillin G

Procaine penicillin G

Product Name
Procaine penicillin G
CAS No.
54-35-3
Chemical Name
Procaine penicillin G
Synonyms
PENICILLIN G PROCAINE;PROCAINE BENZYLPENICILLIN;benzylpenicillin procaine;duphapen;depocillin;hostacillin;hydracillin;rocaine penicillin;Procain-Penicillin;Procain Penicillin G
CBNumber
CB0731029
Molecular Formula
C29H38N4O6S
Formula Weight
570.7
MOL File
54-35-3.mol
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Procaine penicillin G Property

Melting point:
129-130 °C
Density 
1.1335 (rough estimate)
refractive index 
1.6000 (estimate)
storage temp. 
Store at -20°C
solubility 
DMSO: 100 mg/mL (175.22 mM);Ethanol: 20 mg/mL (35.04 mM)
Water Solubility 
Water: 10 mg/mL (17.52 mM)
CAS DataBase Reference
54-35-3
EPA Substance Registry System
4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-[(phenylacetyl)amino]- (2S,5R,6R)-, compd. with 2-(diethylamino)ethyl 4-aminobenzoate (1:1) (54-35-3)
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Safety

Toxicity
LD50 orl-rat: >2 g/kg ABANAE 3,534,55/56
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific
Product number
O634
Product name
ProcainepenicillinG
Packaging
100mg
Price
$89
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0027913
Product name
PROCAINE BENZYL PENICILLIN
Purity
95.00%
Packaging
5MG
Price
$458.16
Updated
2021/12/16
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Procaine penicillin G Chemical Properties,Usage,Production

Chemical Properties

White, fine crystals or powder; odorless; relatively stable to air and light; solutions dextroro- tatory. Sparingly soluble in water; slightly soluble in alcohol; fairly soluble in chloroform.

Originator

Duracillin,Lilly,US,1948

Uses

Antibacterial.

Manufacturing Process

There was added to 250 ml of a concentrated butyl acetate extract containing 74,000 units of the acid form of penicillin per ml, 50 ml of a butyl acetate solution containing 0.238 g per ml of procaine base. The solution was agitated for one hour. The precipitate which formed was very gummy and not in the form of discrete crystals. This precipitate was crystallized by scratching the side of the vessel and agitating further. After this treatment 18.25 g of crystalline procaine penicillin was obtained which assayed 1010 units per mg representing a yield of 99.6% of the activity contained in the concentrated extract.

brand name

Duracillin(Lilly); Pfizerpen (Pfizer).

Therapeutic Function

Antibacterial

General Description

The first widely used amine salt of penicillin G wasmade with procaine. Penicillin G procaine (Crysticillin,Duracillin, Wycillin) can be made readily from penicillin Gsodium by treatment with procaine hydrochloride. This saltis considerably less soluble in water than the alkali metalsalts, requiring about 250 mL to dissolve 1 g. Free penicillinis released only as the compound dissolves and dissociates.It has an activity of 1,009 units/mg. A large number ofpreparations for injection of penicillin G procaine are commerciallyavailable. Most of these are either suspensions inwater to which a suitable dispersing or suspending agent, a buffer, and a preservative have been added or suspensions inpeanut oil or sesame oil that have been gelled by theaddition of 2% aluminum monostearate. Some commercialproducts are mixtures of penicillin G potassium or sodiumwith penicillin G procaine; the water-soluble salt providesrapid development of a high plasma concentration of penicillin,and the insoluble salt prolongs the duration of effect.

Safety Profile

Moderately toxic by intraperitoneal and intramuscular routes. Slightly toxic by ingestion and subcutaneous routes. When heated to decomposition it emits toxic vapors of NOx, and SOx.

Procaine penicillin G Preparation Products And Raw materials

Raw materials

Preparation Products

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Procaine penicillin G Suppliers

North China Pharmaceutical Group first Thai Pharmaceutical Co., Ltd.
Tel
(0311)83098230/83098186
Fax
(0311)83098198
Country
China
ProdList
13
Advantage
60
XiaoGan ShenYuan ChemPharm co,ltd
Tel
0712-0712-2580635 15527768850
Email
1791901229@qq.com
Country
China
ProdList
8850
Advantage
52
Wuhan Fortuna Chemical Co., Ltd
Tel
027-027-59207852 13308628970
Fax
QQ3130921841
Email
buy@fortunachem.com
Country
China
ProdList
2895
Advantage
58
Nanjing Sunlida Biological Technology Co., Ltd.
Tel
025-57798810
Fax
025-57019371
Email
sales@sunlidabio.com
Country
China
ProdList
3750
Advantage
55
TargetMol Chemicals Inc.
Tel
021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7934
Advantage
58
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3404
Advantage
58
Wuhan DKY Technology Co.,Ltd.
Tel
27-81302488 18007166089
Fax
027-81302088
Email
info@dkybpc.com
Country
China
ProdList
2024
Advantage
58
Hubei XinyuanShun Chemical Co., Ltd.
Tel
13971561712, 13995564702, 027-50664929
Fax
027-50664927
Email
hbeixys2001@163.com
Country
China
ProdList
3123
Advantage
55
Finetech Industry Limited
Tel
027-87465837 19945049750
Fax
027-8777-2287
Email
sales@finetechnology-ind.com
Country
China
ProdList
9590
Advantage
58
Wuhan Dahua Pharmaceutical Co., Ltd.
Tel
027-59262863 13277907145 3091977954
Fax
027-59420980
Country
China
ProdList
4951
Advantage
58
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View Lastest Price from Procaine penicillin G manufacturers

Hebei Duling International Trade Co. LTD
Product
procaine penicillin 54-35-3
Price
US $3.90/kg
Min. Order
1kg
Purity
99%
Supply Ability
100 tons
Release date
2022-10-25
Hebei Yibangte Import and Export Co. , Ltd.
Product
Procaine penicillin G 54-35-3
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
50000kg
Release date
2023-11-21
Shaanxi Haibo Biotechnology Co., Ltd
Product
Procaine penicillin G 54-35-3
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
2000ton
Release date
2023-09-04

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