ChemicalBook > CAS DataBase List > Procaine penicillin G

Procaine penicillin G

Product Name
Procaine penicillin G
CAS No.
54-35-3
Chemical Name
Procaine penicillin G
Synonyms
PENICILLIN G PROCAINE;PROCAINE BENZYLPENICILLIN;benzylpenicillin procaine;duphapen;depocillin;hostacillin;hydracillin;rocaine penicillin;Procain-Penicillin;Procain Penicillin G
CBNumber
CB0731029
Molecular Formula
C29H38N4O6S
Formula Weight
570.7
MOL File
54-35-3.mol
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Procaine penicillin G Property

Melting point:
129-130 °C
Density 
1.1335 (rough estimate)
refractive index 
1.6000 (estimate)
storage temp. 
Store at -20°C
solubility 
DMSO: 100 mg/mL (175.22 mM);Ethanol: 20 mg/mL (35.04 mM)
Water Solubility 
Water: 10 mg/mL (17.52 mM)
CAS DataBase Reference
54-35-3
EPA Substance Registry System
4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-[(phenylacetyl)amino]- (2S,5R,6R)-, compd. with 2-(diethylamino)ethyl 4-aminobenzoate (1:1) (54-35-3)
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Safety

Toxicity
LD50 orl-rat: >2 g/kg ABANAE 3,534,55/56
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific
Product number
O634
Product name
ProcainepenicillinG
Packaging
100mg
Price
$89
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0027913
Product name
PROCAINE BENZYL PENICILLIN
Purity
95.00%
Packaging
5MG
Price
$458.16
Updated
2021/12/16
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Procaine penicillin G Chemical Properties,Usage,Production

Chemical Properties

White, fine crystals or powder; odorless; relatively stable to air and light; solutions dextroro- tatory. Sparingly soluble in water; slightly soluble in alcohol; fairly soluble in chloroform.

Originator

Duracillin,Lilly,US,1948

Uses

Antibacterial.

Manufacturing Process

There was added to 250 ml of a concentrated butyl acetate extract containing 74,000 units of the acid form of penicillin per ml, 50 ml of a butyl acetate solution containing 0.238 g per ml of procaine base. The solution was agitated for one hour. The precipitate which formed was very gummy and not in the form of discrete crystals. This precipitate was crystallized by scratching the side of the vessel and agitating further. After this treatment 18.25 g of crystalline procaine penicillin was obtained which assayed 1010 units per mg representing a yield of 99.6% of the activity contained in the concentrated extract.

brand name

Duracillin(Lilly); Pfizerpen (Pfizer).

Therapeutic Function

Antibacterial

General Description

The first widely used amine salt of penicillin G wasmade with procaine. Penicillin G procaine (Crysticillin,Duracillin, Wycillin) can be made readily from penicillin Gsodium by treatment with procaine hydrochloride. This saltis considerably less soluble in water than the alkali metalsalts, requiring about 250 mL to dissolve 1 g. Free penicillinis released only as the compound dissolves and dissociates.It has an activity of 1,009 units/mg. A large number ofpreparations for injection of penicillin G procaine are commerciallyavailable. Most of these are either suspensions inwater to which a suitable dispersing or suspending agent, a buffer, and a preservative have been added or suspensions inpeanut oil or sesame oil that have been gelled by theaddition of 2% aluminum monostearate. Some commercialproducts are mixtures of penicillin G potassium or sodiumwith penicillin G procaine; the water-soluble salt providesrapid development of a high plasma concentration of penicillin,and the insoluble salt prolongs the duration of effect.

Safety Profile

Moderately toxic by intraperitoneal and intramuscular routes. Slightly toxic by ingestion and subcutaneous routes. When heated to decomposition it emits toxic vapors of NOx, and SOx.

Procaine penicillin G Preparation Products And Raw materials

Raw materials

Hexyl acetate Penicillin G potassium salt Procaine hydrochloride

Preparation Products

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View Lastest Price from Procaine penicillin G manufacturers

Hebei Mujin Biotechnology Co.,Ltd
Product
Procaine penicillin G 54-35-3
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-07-28
Hebei Kingfiner Technology Development Co.Ltd
Product
Procaine penicillin G 54-35-3
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
50000kg
Release date
2023-11-21
Shaanxi TNJONE Pharmaceutical Co., Ltd
Product
Procaine Benzylpenicillin 54-35-3
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20tons
Release date
2024-04-29

54-35-3, Procaine penicillin GRelated Search:

Penicillin G Penicillin G potassium salt Penicillin G sodium salt PENICILLIN V Penicillin V potassium salt Procaine Procaine hydrochloride Benzathine benzylpenicillin PROCAINE PENICILLIN Carbenicillin Disodium Salt Penicillin Procaine penicillin G PROCAINE BENZYLPENICILLIN (PROCAINE PENICILLIN) Penicillin G Procaine/Sodium 3:1 Penicillin G procaine/Benzathine 4:1 Penicillin G procaine/Potassium 3:1 Procaine penicillin G(fortified) p-Toluidine, alpha-(2-(diethylamino)ethoxy)- Benzylpenicillin Procaine

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  • 54-35-3
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  • C16H18N2O4SC13H20N2O
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  • 54-35-3