Baicalein
- Product Name
- Baicalein
- CAS No.
- 491-67-8
- Chemical Name
- Baicalein
- Synonyms
- 5,6,7-trihydroxy-2-phenyl-4H-chroMen-4-one;Baicelein;5,6,7-Trihydroxyflavone,97%;BaicaL;Noroxylin;Baicalein;Baicaleine;Baicalein-RM;Baicalein 98%;Baicalein std.
- CBNumber
- CB0738154
- Molecular Formula
- C15H10O5
- Formula Weight
- 270.24
- MOL File
- 491-67-8.mol
Baicalein Property
- Melting point:
- 256-271 °C (lit.)
- Boiling point:
- 373.35°C (rough estimate)
- Density
- 1.3280 (rough estimate)
- refractive index
- 1.5000 (estimate)
- storage temp.
- Keep in dark place,Sealed in dry,2-8°C
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Yellow solid
- pka
- 6.31±0.40(Predicted)
- color
- Yellow or yellow-green
- Merck
- 14,942
- BRN
- 272683
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 week.
- InChIKey
- FXNFHKRTJBSTCS-UHFFFAOYSA-N
- LogP
- 3.310 (est)
- CAS DataBase Reference
- 491-67-8(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-20/21/22
- Safety Statements
- 26-36
- WGK Germany
- 3
- RTECS
- DJ3100898
- Hazard Note
- Irritant
- HS Code
- 29329990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 465119
- Product name
- Baicalein
- Purity
- 98%
- Packaging
- 100mg
- Price
- $51.4
- Updated
- 2025/07/31
- Product number
- 196322
- Product name
- Baicalein
- Packaging
- 10mg
- Price
- $150
- Updated
- 2025/07/31
- Product number
- T2721
- Product name
- Baicalein
- Purity
- >98.0%(T)
- Packaging
- 1g
- Price
- $188
- Updated
- 2025/07/31
- Product number
- T2721
- Product name
- Baicalein
- Purity
- >98.0%(T)
- Packaging
- 5g
- Price
- $469
- Updated
- 2025/07/31
- Product number
- 70610
- Product name
- Baicalein
- Purity
- ≥95%
- Packaging
- 50mg
- Price
- $18
- Updated
- 2024/03/01
Baicalein Chemical Properties,Usage,Production
Description
Baicalein (491-67-8) is an inhibitor of protein tyrosine kinase in leukemia (CEM) cells. Induces cell cycle arrest and apoptosis.1?Originally reported as a selective inhibitor of 12-lipoxygenase, baicalein has since been shown to inhibit both 12-LO and 15-LO (IC50=0.64 μM for 12-LO and 1.6 μM for 15-LO).2 Baicalein displays anti-inflammatory activity and inhibits adjuvant-induced arthritis. Also inhibits prolyl oligopeptidase (IC50=36 μM).3
Chemical Properties
Yellow Crystalline Solid
Uses
Baicalein is a flavonoid originally isolated from the roots of Scutellaria baicalensis Georgi. Several different functions of baicalein have been reported. Platelet 12-lipoxygenase is inhibited by baicalein with an ID50 value of 0.12 μM, with minimal inhibition of platelet cyclooxygenase-1 (IC50 = 0.83 mM). Baicalein inhibits lipid peroxidation, as assessed by production of TBARS, with an IC50 value of 5 μM. In addition to these effects, baicalein may play a role in apoptosis, as the compound inhibits cell growth of three human hepatocellular carcinoma cell lines with IC50 values ranging from 17-70 μg/ml.
Uses
antiviral (HIV)
Uses
An inhibitor of 12-lipoxygenase, leukotriene biosynthesis and release of lysosomal enzymes. It also inhibits cellular Ca2+ uptake and mobilization and adjuvant-induced arthritis. Baicalein is the fl avonoid component of Nepalese and Sino-Japanese crude drugs.
Uses
inhibitor of lipoxidase and leukotriene biosynthesis
Uses
An inhibitor of Ca2+ uptake, 5-LO, and 12-LO
Definition
ChEBI: A trihydroxyflavone with the hydroxy groups at positions C-5, -6 and -7.
General Description
Baicalein, a flavonoid, is a xanthine oxidase inhibitor. Anti-inflammatory effects of baicalein in peripheral human leukocytes has been studied.
Biological Activity
Inhibitor of 5- and platelet 12-lipoxygenases (IC 50 values are 9.5 and 0.12 mM respectively). Also inhibits Raf-mediated MEK-1 phosphorylation in C6 rat glioma cells and induces G1 and G2 cell cycle arrest by decreasing cdk1, cdk2, cyclin D2 and cyclin A expression. Anti-inflammatory in vivo .
Biochem/physiol Actions
The flavonoid component of Nepalese and Sino-Japanese crude drugs. Baicalein, a major flavone of Scutellariae baicalensis, inhibits the 12-lipoxygenase (12-LOX) pathway of arachidonic acid metabolism, which inhibits cancer cell proliferation and induces apoptosis.
References
[1] HONG Z LEE. Baicalein induced cell cycle arrest and apoptosis in human lung squamous carcinoma CH27 cells.[J]. Anticancer research, 2005, 25 2A: 959-964.
[2] JOSHUA D. DESCHAMPS Theodore R H Victor A Kenyon. Baicalein is a potent in vitro inhibitor against both reticulocyte 15-human and platelet 12-human lipoxygenases[J]. Bioorganic & Medicinal Chemistry, 2006, 14 12: Pages 4295-4301. DOI:10.1016/j.bmc.2006.01.057
[3] TERESA TARRAGÓ . Baicalin, a prodrug able to reach the CNS, is a prolyl oligopeptidase inhibitor[J]. Bioorganic & Medicinal Chemistry, 2008, 16 15: Pages 7516-7524. DOI:10.1016/j.bmc.2008.04.067
Baicalein Preparation Products And Raw materials
Raw materials
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View Lastest Price from Baicalein manufacturers
- Product
- Baicalein 491-67-8
- Price
- US $1200.00-1100.00/ton
- Min. Order
- 1ton
- Purity
- 99%
- Supply Ability
- 1000T/M
- Release date
- 2025-10-21
- Product
- Baicalin 491-67-8
- Price
- US $1200.00-1100.00/ton
- Min. Order
- 1ton
- Purity
- 99%
- Supply Ability
- 1000T/M
- Release date
- 2025-10-13
- Product
- Baicalein 491-67-8
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 1000kg
- Release date
- 2025-04-25