Amobarbital Property

Melting point:

156-158°C

Boiling point:

367.89°C (rough estimate)

Density 

1.1376 (rough estimate)

refractive index 

1.4620 (estimate)

Flash point:

9℃

storage temp. 

-20°C

pka

8.0(at 25℃)

color 

bitter crystals or leaflets from water

Water Solubility 

<0.1 g/100 mL at 18.5 ºC

Stability:

Stable. Incompatible with strong oxidizing agents. Hygroscopic.

CAS DataBase Reference

57-43-2(CAS DataBase Reference)

NIST Chemistry Reference

Barbituric acid, 5-ethyl-5-isoamyl-(57-43-2)

EPA Substance Registry System

Amobarbital (57-43-2)

Safety

Hazard Codes 

F,T

Risk Statements 

11-23/24/25-39/23/24/25

Safety Statements 

16-36/37-45

RIDADR 

3249

WGK Germany 

1

HazardClass 

6.1(b)

PackingGroup 

III

HS Code 

2933530000

Hazardous Substances Data

57-43-2(Hazardous Substances Data)

Toxicity

LD50 in mice (mg/kg): 212 s.c. (Irrgang)

DEA Controlled Substances

CSCN: 2126
CSA SCH: Schedule III
NARC: No

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H336May cause drowsiness or dizziness

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

Amobarbital Chemical Properties,Usage,Production

Chemical Properties

Crystalline Solid

Originator

Hypnotal,Pharmacal

Uses

Controlled substance (depressant). Sedative, hypnotic

Uses

Sedative, hypnotic. Controlled substance (depressant).

Uses

Amobarbital for binding at complex I to inhibit mitochondrial electron transport. Amobarbital is regulated as a schedule II compound in the United States and intended only for forensic and research purposes.
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Definition

ChEBI: A member of the class of barbiturates that is pyrimidine-2,4,6(1H,3H,5H)-trione substituted by a 3-methylbutyl and an ethyl group at position 5. Amobarbital has been shown to exhibit sedative and hy notic properties.

Manufacturing Process

By interaction of malonic acid diethyl ester with sodium ethylate (molar ratio 1:1) and then with ethyl bromide (molar ratio 1:1) was prepared ethylmalonic acid diethyl ester. From ethylmalonic acid diethyl ester and sodium ethylate (molar ratio 1:1) and then with isopentylbromide was synthesized α-ethyl-α- isopentylmalonic acid diethyl ester. By condensation of α-ethyl-α- isopentylmalonic acid diethyl ester with urea in the presence of sodium ethylate was obtained ethyl-isopentylbarbituric acid.

brand name

Amytal Sodium (Lilly); Talamo (Marion Merrell Dow);Altinal;Alupent-sed;Ambese-la;Amobell;Amsal;Amycal;Amydorm;Amylbarb;Amylobeta;Analgilasa;Appenil;Asthmin;Beatol;Bludex;Calavon;Cuaot;Dexaspan;Dexital;Ergo-lonarid;Estimal;Etamyl;Ifenin;Isoamitil sedante;Isobec;Jalonac;Lonarid n;Medi-trol;Mudeka;Mylodorm sustrel;N 8;Neur-amyl;Novambobarb;Novogen;Obe_slim;Placidel;Protasma;Sedo-rythmodan;Sy-dexam;Transital.

Therapeutic Function

Hypnotic, Antiepileptic

World Health Organization (WHO)

Amobarbital is an intermediate-acting barbiturate which is controlled under Schedule III of the 1971 Convention on Psychotropic Substances. See WHO comment for barbiturates. (Reference: (UNCPS3) United Nations Convention on Psychotropic Substances (III), , , 1971)

General Description

White crystalline solid with no odor and a slightly bitter taste.

Air & Water Reactions

Amobarbital is hygroscopic . Insoluble in water.

Reactivity Profile

Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.

Hazard

May be a habit forming drug of abuse.

Fire Hazard

Flash point data for Amobarbital are not available, however, Amobarbital is probably combustible.

Safety Profile

A poison by ingestion,intravenous, intraperitoneal, and subcutaneous routes. Seealso BARBITURATES. When heated to decomposition itemits toxic fumes of NOx.