ChemicalBook > CAS DataBase List > 4-FORMYL-3-HYDROXYBENZOIC ACID

4-FORMYL-3-HYDROXYBENZOIC ACID

Product Name
4-FORMYL-3-HYDROXYBENZOIC ACID
CAS No.
619-12-5
Chemical Name
4-FORMYL-3-HYDROXYBENZOIC ACID
Synonyms
4-CARBOXYSALICYALDEHYDE;4-FORMYL-3-HYDROXYBENZOIC ACID;3-Hydroxy-4-formylbenzoic acid;Benzoic acid, 4-forMyl-3-hydroxy-;4-Formyl-3-hydroxybenzoic acid 97%;3-hydroxy-4-methanoyl-benzoic acid
CBNumber
CB0749932
Molecular Formula
C8H6O4
Formula Weight
166.13
MOL File
619-12-5.mol
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4-FORMYL-3-HYDROXYBENZOIC ACID Property

Melting point:
235-240 °C (lit.)
Boiling point:
214.32°C (rough estimate)
Density 
1.2208 (rough estimate)
refractive index 
1.4611 (estimate)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
form 
solid
pka
3.66±0.10(Predicted)
Appearance
White to light brown Solid
InChI
InChI=1S/C8H6O4/c9-4-6-2-1-5(8(11)12)3-7(6)10/h1-4,10H,(H,11,12)
InChIKey
FDDHFCWYCKQKGY-UHFFFAOYSA-N
SMILES
C(O)(=O)C1=CC=C(C=O)C(O)=C1
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Safety

Hazard Codes 
Xn
Risk Statements 
22-36/38-43
Safety Statements 
26-36
WGK Germany 
2
HS Code 
2918999090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
633461
Product name
4-Formyl-3-hydroxybenzoic acid
Purity
95%
Packaging
1g
Price
$213
Updated
2023/06/20
Sigma-Aldrich
Product number
633461
Product name
4-Formyl-3-hydroxybenzoic acid
Purity
95%
Packaging
5g
Price
$755
Updated
2023/06/20
TRC
Product number
B414230
Product name
4-Formyl-3-hydroxybenzoic acid
Packaging
50mg
Price
$45
Updated
2021/12/16
Matrix Scientific
Product number
118984
Product name
4-Formyl-3-hydroxybenzoic acid
Purity
95+%
Packaging
1g
Price
$198
Updated
2021/12/16
AK Scientific
Product number
W7396
Product name
4-Formyl-3-hydroxybenzoic acid
Packaging
5g
Price
$497
Updated
2021/12/16
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4-FORMYL-3-HYDROXYBENZOIC ACID Chemical Properties,Usage,Production

Uses

4-Formyl-3-hydroxybenzoic acid can be used as a reactant to prepare:

  • A pH-sensitive fluorescent probe 4,4′-(hydrazine-1,2-diylidene bis(methanylylidene)) bis(3-hydroxybenzoic acid (HDBB) by one-step condensation reaction with hydrazine.
  • 2-Oxo-2H-1-benzopyran-3,7-dicarboxylic acid by condensation reaction with diethyl malonate.
  • Schiff base ligands for the preparation of stable and functional Schiff base metal complexes.

Synthesis

100-97-0

99-06-9

619-12-5

GENERAL METHOD: Hexamethylenetetramine (0.3 mmol) and cuprous oxide (0.15 mmol) were sequentially added to a solution of trifluoroacetic acid (5 mL) of the substrate (1a-1q, 0.15 mmol). The reaction mixture was heated to reflux for 5 h and subsequently cooled to room temperature. 3N hydrochloric acid (5 mL) was slowly added to the reaction system and stirring was continued for 1 hour. Upon completion of the reaction, the mixture was concentrated under reduced pressure to remove the solvent. The crude product was purified by silica gel column chromatography (200-300 mesh) to afford the target compound 4-formyl-3-hydroxybenzoic acid.

References

[1] Research on Chemical Intermediates, 2015, vol. 41, # 11, p. 8147 - 8158

4-FORMYL-3-HYDROXYBENZOIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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4-FORMYL-3-HYDROXYBENZOIC ACID Suppliers

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View Lastest Price from 4-FORMYL-3-HYDROXYBENZOIC ACID manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
4-FORMYL-3-HYDROXYBENZOIC ACID 619-12-5
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-27
Career Henan Chemical Co
Product
4-FORMYL-3-HYDROXYBENZOIC ACID 619-12-5
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1ton
Release date
2018-08-06

619-12-5, 4-FORMYL-3-HYDROXYBENZOIC ACIDRelated Search:

2,5-Dihydroxyterephthalic acid Diacerein 2-(Trifluoromethoxy)terephthalic acid Sennoside A DIETHYL 2,5-DIHYDROXYTEREPHTHALATE 5-HYDROXYBENZENE-1,2,4-TRICARBOXYLIC ACID Sennoside B Rhein SENNOSIDE 5-FORMYL-2-HYDROXYBENZOIC ACID METHYL ESTER 5-FORMYL-2-HYDROXYBENZOIC ACID 4-Formylbenzoic acid 3-Hydroxybenzoic acid 4-(2,6-dihydroxybenzoyl)-3-formyl-5-hydroxybenzoic acid RHEIN-8-GLUCOSIDE CALCIUM SENNOSIDE SENNIDINE A SENNIDINE B

  • 3-Hydroxy-4-formylbenzoic acid
  • 3-hydroxy-4-methanoyl-benzoic acid
  • 4-FORMYL-3-HYDROXYBENZOIC ACID
  • 4-CARBOXYSALICYALDEHYDE
  • Benzoic acid, 4-forMyl-3-hydroxy-
  • 4-Formyl-3-hydroxybenzoic acid 97%
  • 619-12-5
  • Carbonyl Compounds
  • C8
  • Aldehydes
  • Building Blocks
  • Organic Building Blocks
  • Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
  • Aldehydes
  • C8
  • Carbonyl Compounds
  • Building Blocks
  • Carbonyl Compounds
  • Chemical Synthesis
  • Organic Building Blocks