Diacerein
Immunosuppressive drugs Uses- Product Name
- Diacerein
- CAS No.
- 13739-02-1
- Chemical Name
- Diacerein
- Synonyms
- DAR;Diacereine;SF 277;artrodar;Fisiodar;ICN17261;DIACEREIN;ICN 17261;ICN-17261;Diacetine
- CBNumber
- CB0755179
- Molecular Formula
- C19H12O8
- Formula Weight
- 368.29
- MOL File
- 13739-02-1.mol
Diacerein Property
- Melting point:
- 217-2180C
- Boiling point:
- 631.5±55.0 °C(Predicted)
- Density
- 1.491±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO (Sparingly), Methanol (Slightly)
- form
- Solid
- pka
- 3.01±0.20(Predicted)
- color
- Light Yellow to Yellow
- Water Solubility
- 240μg/L at 25℃
- Merck
- 14,2960
- InChIKey
- TYNLGDBUJLVSMA-UHFFFAOYSA-N
- LogP
- 3.126 (est)
- CAS DataBase Reference
- 13739-02-1(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- Y0001595
- Product name
- Diacerein
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- y0001595
- Price
- $153
- Updated
- 2024/03/01
- Product number
- D9302
- Product name
- Diacerein
- Purity
- ≥95% (HPLC)
- Packaging
- 50mg
- Price
- $85.6
- Updated
- 2024/03/01
- Product number
- D4061
- Product name
- Diacerein
- Purity
- >98.0%(HPLC)
- Packaging
- 1g
- Price
- $101
- Updated
- 2024/03/01
- Product number
- D4061
- Product name
- Diacerein
- Purity
- >98.0%(HPLC)
- Packaging
- 5g
- Price
- $261
- Updated
- 2024/03/01
- Product number
- J63775
- Product name
- Diacerein
- Packaging
- 1g
- Price
- $167.65
- Updated
- 2024/03/01
Diacerein Chemical Properties,Usage,Production
Immunosuppressive drugs
Diacerein is a novel interleukin (IL)-1 inhibitor , the chemical name is diacetyl rhein,it is a compound of anthraquinones, the product can induce cartilage generation, it has analgesic, antipyretic and anti-inflammatory effects, but also it can significantly improve joint function in patients with osteoarthritis, and delay duration, and reduce pain to improve the quality of life of patients, it has better security, it is mainly used in clinical treatment of osteoarthritis (OA) to exert an antibacterial effect.
Solubility: soluble in dimethyl sulfoxide, dimethyl acetamide; insoluble in water, methanol, chloroform.
Diacerein and its active metabolite rhubarb (rhein) can reduce the generation and activity of IL-1β by inhibiting IL-1 converting enzyme. Mechanisms include:
1, inhibit the IL-1 synthesis of synovial tissue.
2, inhibit the expression of IL-1 receptor in chondrocytes .
3, inhibition of IL-1 activity.
4, repress formation of metalloproteinases such as collagenase and matrix dissolved elements and peroxide.
5, promote the synthesis of collagen and glycosaminoglycan.
6, inhibit the leukocyte chemotaxis and lysosomal stability.
Diacerein does not change the cyclooxygenase activity of kidneys and platelets, and does not inhibit the synthesis of prostaglandin , so prostaglandin-dependent renal dysfunction patients can tolerate.
Oral 50mg, PPB is 99%, Tmax is 2.2 h, Cmax is 3.2 mg/L, AUC is 21.3 mg • h/L, T1/2β is 4.3 h. Tmax and AUC values can be increased if it is administrated with food .
Adverse reactions: 50% of patients suffer diarrhea, abdominal pain and loose stools.
The above information is edited by the chemicalbook of Tian Ye.
Uses
It is widely used in new liquid crystal polymer, engineering plastics and high-strength fibers with high performance.
This product is an important osteoarthritis IL-1 inhibitor. It is used for osteoarthritis.
It is a natural antioxidant, it has anti-aging, enhance immunity, removing sub-health state, physical recovery, increasing energy and body immunity effects.
Description
Diacerein is a disease-modifying antirheumatic drug (DMARD), reported to be useful in the treatment of various inflammatory conditions, including osteoarthritis. It forms water soluble chelates with calcium and copper, acting ultimately to reduce the activity of lysosomal enzymes and decrease the formation of rheumatoid factor.
Chemical Properties
Yellow Crystalline Solid
Originator
Proter (Italy)
Uses
A diacetyl derivative of Rhein. Demonstrates anti-arthritic activity without inhibiting prostaglandin synthesis. Antiarthritic
Uses
antiinflammatory
Uses
A diacetyl derivative of Rhein (R318500). Demonstrates anti-arthritic activity without inhibiting prostaglandin synthesis. Antiarthritic.
Uses
Treatment of Osteoarthritis (Prevent cartilage destruction)
Uses
Diacerein is a diacetyl precursor of rhein, an anthraquinone found in plants. Rhein, at 10 μM, inhibits IL-1β signaling, suppressing signaling through NF-κB and AP-1, and reduces the expression of the matrix metalloproteases MMP-1 and MMP-13. Diacerein, presumably after conversion to rhein, down-regulates the expression of the IL-1β receptor on articular chondrocytes, enhances the expression of TGF-β, and increases collagen and aggrecan. It does not alter COX activity. It is mildly effective in ameliorating osteoarthritis.
Definition
ChEBI: 4,5-diacetyloxy-9,10-dioxo-2-anthracenecarboxylic acid is an anthraquinone.
brand name
ARTRODAR
Diacerein Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Diacerein manufacturers
- Product
- Diacerein 13739-02-1
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- >98%
- Supply Ability
- 1000 kg
- Release date
- 2024-04-25
- Product
- Diacerein 13739-02-1
- Price
- US $500.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2021-06-07
- Product
- Diacerein 13739-02-1
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-10-31