Immunosuppressive drugs Uses
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Diacerein

Immunosuppressive drugs Uses
Product Name
Diacerein
CAS No.
13739-02-1
Chemical Name
Diacerein
Synonyms
DAR;Diacereine;SF 277;artrodar;Fisiodar;ICN17261;DIACEREIN;ICN 17261;ICN-17261;Diacetine
CBNumber
CB0755179
Molecular Formula
C19H12O8
Formula Weight
368.29
MOL File
13739-02-1.mol
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Diacerein Property

Melting point:
217-2180C
Boiling point:
631.5±55.0 °C(Predicted)
Density 
1.491±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMSO (Sparingly), Methanol (Slightly)
form 
Solid
pka
3.01±0.20(Predicted)
color 
Light Yellow to Yellow
Water Solubility 
240μg/L at 25℃
Merck 
14,2960
InChIKey
TYNLGDBUJLVSMA-UHFFFAOYSA-N
LogP
3.126 (est)
CAS DataBase Reference
13739-02-1(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
RTECS 
CB8781000
HS Code 
29146990
Toxicity
rat,LD50,unreported,7500mg/kg (7500mg/kg),Drugs of the Future. Vol. 4, Pg. 445, 1979.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
Y0001595
Product name
Diacerein
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
y0001595
Price
$153
Updated
2024/03/01
Sigma-Aldrich
Product number
D9302
Product name
Diacerein
Purity
≥95% (HPLC)
Packaging
50mg
Price
$85.6
Updated
2024/03/01
TCI Chemical
Product number
D4061
Product name
Diacerein
Purity
>98.0%(HPLC)
Packaging
1g
Price
$101
Updated
2024/03/01
TCI Chemical
Product number
D4061
Product name
Diacerein
Purity
>98.0%(HPLC)
Packaging
5g
Price
$261
Updated
2024/03/01
Alfa Aesar
Product number
J63775
Product name
Diacerein
Packaging
1g
Price
$167.65
Updated
2024/03/01
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Diacerein Chemical Properties,Usage,Production

Immunosuppressive drugs

Diacerein is a novel interleukin (IL)-1 inhibitor , the chemical name is diacetyl rhein,it is a compound of anthraquinones, the product can induce cartilage generation, it has analgesic, antipyretic and anti-inflammatory effects, but also it can significantly improve joint function in patients with osteoarthritis, and delay duration, and reduce pain to improve the quality of life of patients, it has better security, it is mainly used in clinical treatment of osteoarthritis (OA) to exert an antibacterial effect.
Solubility: soluble in dimethyl sulfoxide, dimethyl acetamide; insoluble in water, methanol, chloroform.
Diacerein and its active metabolite rhubarb (rhein) can reduce the generation and activity of IL-1β by inhibiting IL-1 converting enzyme. Mechanisms include:
1, inhibit the IL-1 synthesis of synovial tissue.
2, inhibit the expression of IL-1 receptor in chondrocytes .
3, inhibition of IL-1 activity.
4, repress formation of metalloproteinases such as collagenase and matrix dissolved elements and peroxide.
5, promote the synthesis of collagen and glycosaminoglycan.
6, inhibit the leukocyte chemotaxis and lysosomal stability.
Diacerein does not change the cyclooxygenase activity of kidneys and platelets, and does not inhibit the synthesis of prostaglandin , so prostaglandin-dependent renal dysfunction patients can tolerate.
Oral 50mg, PPB is 99%, Tmax is 2.2 h, Cmax is 3.2 mg/L, AUC is 21.3 mg • h/L, T1/2β is 4.3 h. Tmax and AUC values can be increased if it is administrated with food .
Adverse reactions: 50% of patients suffer diarrhea, abdominal pain and loose stools.
The above information is edited by the chemicalbook of Tian Ye.

Uses

It is widely used in new liquid crystal polymer, engineering plastics and high-strength fibers with high performance.
This product is an important osteoarthritis IL-1 inhibitor. It is used for osteoarthritis.
It is a natural antioxidant, it has anti-aging, enhance immunity, removing sub-health state, physical recovery, increasing energy and body immunity effects.

Description

Diacerein is a disease-modifying antirheumatic drug (DMARD), reported to be useful in the treatment of various inflammatory conditions, including osteoarthritis. It forms water soluble chelates with calcium and copper, acting ultimately to reduce the activity of lysosomal enzymes and decrease the formation of rheumatoid factor.

Chemical Properties

Yellow Crystalline Solid

Originator

Proter (Italy)

Uses

A diacetyl derivative of Rhein. Demonstrates anti-arthritic activity without inhibiting prostaglandin synthesis. Antiarthritic

Uses

antiinflammatory

Uses

A diacetyl derivative of Rhein (R318500). Demonstrates anti-arthritic activity without inhibiting prostaglandin synthesis. Antiarthritic.

Uses

Treatment of Osteoarthritis (Prevent cartilage destruction)

Uses

Diacerein is a diacetyl precursor of rhein, an anthraquinone found in plants. Rhein, at 10 μM, inhibits IL-1β signaling, suppressing signaling through NF-κB and AP-1, and reduces the expression of the matrix metalloproteases MMP-1 and MMP-13. Diacerein, presumably after conversion to rhein, down-regulates the expression of the IL-1β receptor on articular chondrocytes, enhances the expression of TGF-β, and increases collagen and aggrecan. It does not alter COX activity. It is mildly effective in ameliorating osteoarthritis.

Definition

ChEBI: 4,5-diacetyloxy-9,10-dioxo-2-anthracenecarboxylic acid is an anthraquinone.

brand name

ARTRODAR

Diacerein Preparation Products And Raw materials

Raw materials

Preparation Products

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Diacerein Suppliers

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View Lastest Price from Diacerein manufacturers

Baoji Guokang Bio-Technology Co., Ltd.
Product
Diacerein 13739-02-1
Price
US $500.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2021-06-07
BINBO BIOLOGICAL CO.,LTD
Product
Diacerein 13739-02-1
Price
US $0.00/kg
Min. Order
1kg
Purity
>98%
Supply Ability
1000 kg
Release date
2024-04-25
Hebei Weibang Biotechnology Co., Ltd
Product
Diacerein 13739-02-1
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-10-31

13739-02-1, DiacereinRelated Search:

Meloxicam 4-Acetylbenzoic acid Aloe emodin 4-ETHYL-3-HYDROXYBENZOIC ACID Chrysophanic acid 3'-Acetoxyacetophenone 3-ACETOXYBENZOIC ACID Diacerein ANTHRAQUINONE-2-CARBOXYLIC ACID 4-FORMYL-3-HYDROXYBENZOIC ACID 1-methoxyanthraquinone 3-Methoxy-4-methylbenzoic acid 3-Hydroxy-4-methylbenzoic acid Rhein 2-ANTHRACENECARBOXYLIC ACID 3-METHOXY-3'-METHYLBENZOPHENONE 2-ACETOXYBENZOPHENONE 3-ACETOXY-3'-METHOXYBENZOPHENONE

  • 1,8-DIACETOXY-3-CARBOXYANTHRAQUINONE
  • DIACEREIN
  • DIACERHEIN
  • DIACETYL RHEIN
  • 9,10-dihydro-4,5-diacetoxy-9,10-2-anthracenecarboxylicacid
  • 9,10-dihydro-4,5-dihydroxy-9,10-dioxo-2-anthroicaciddiacetate
  • 9,10-dihydro-4,5-dihydroxy-9,10-dioxo-2-anthroicacidiacetate
  • artrodar
  • rhein,diacetate
  • 4,5-Bis(acetyloxy)-9,10-dioxo-2-anthracenecarboxylic acid
  • 4,5-Bis(acetyloxy)-9,10-dihydro-9,10-dioxo-2-anthracenecarboxylic Acid
  • Diacereine
  • Diacerein, ≥95%（HPLC)
  • 4,5-diacetyloxy-9,10-dioxo-2-anthracenecarboxylic acid
  • Diacerein 13739-02-1
  • 1,8-diacetoxyanthraquinone-3-carboxylicacid
  • 4,5-bis(acetyloxy)-9,10-dihydro-9,10-dioxo-2-anthracenecarboxylicaci
  • 4,5-diacetylrhein
  • 4,5-Diacetoxy-9,10-dihydro-9,10-dioxo-2-anthracenecarboxylic acid
  • 4,5-Diacetoxy-9,10-dioxo-2-anthracenecarboxylic acid
  • 4,5-diacetoxy-9,10-diketo-anthracene-2-carboxylic acid
  • 4,5-diacetyloxy-9,10-dioxo-anthracene-2-carboxylic acid
  • 4,5-diacetyloxy-9,10-dioxoanthracene-2-carboxylic acid
  • Diacerein (1,8-Diacetoxy-3-carboxyanthraquinone)
  • 4,5-Diacetoxyanthraquinone-2-carboxylic Acid
  • DAR
  • Fisiodar
  • SF 277
  • 4,5-diacetoxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid
  • DIACETYL RHEIN(P)
  • DIACERHEIN;DIACETYLRHEIN;FISIODAR;ARTRODAR
  • Diacerein CRS
  • Diacerein&gt
  • Diacerein impurity mixture CRS
  • 2-Anthracenecarboxylic acid, 4,5-bis(acetyloxy)-9,10-dihydro-9,10-dioxo-
  • Diacerein for Arthritis Treatment
  • Diacerein USP/EP/BP
  • Diacerein (Diacerhein)
  • Diacerein(Y0001595)
  • DiacereinQ: What is Diacerein Q: What is the CAS Number of Diacerein Q: What is the storage condition of Diacerein Q: What are the applications of Diacerein
  • Diacerein API
  • ICN 17261
  • ICN17261
  • ICN-17261
  • Diacerein, ≥ 98.0%
  • Diacerhein|||Fisiodar|||Diacetylrhein
  • Diacerein IP/EP
  • Diacetine
  • 13739-02-1
  • C19H12O8
  • Analytical Standards
  • Analytical Chromatography Product Catalog
  • Drug Standards
  • Chromatography
  • Forensic and Veterinary Standards
  • Miscellaneous Biochemicals
  • Aromatics Compounds
  • Aromatics