Kinetin
- Product Name
- Kinetin
- CAS No.
- 525-79-1
- Chemical Name
- Kinetin
- Synonyms
- KT;fap;cytokinin;6-FURFURYLAMINOPURINE;N6-FURFURYLADENINE;N-[(Fur-2-yl)methyl]-9H-purin-6-amine;KINETINE;Kinetina;Kinetin (6-Furfuryladenine);H35
- CBNumber
- CB0758226
- Molecular Formula
- C10H9N5O
- Formula Weight
- 215.21
- MOL File
- 525-79-1.mol
Kinetin Property
- Melting point:
- 269-271 °C (dec.)(lit.)
- Boiling point:
- 355.49°C (rough estimate)
- Density
- 1.2639 (rough estimate)
- refractive index
- 1.7610 (estimate)
- Flash point:
- 269-271°C
- storage temp.
- -70°C
- solubility
- H2O: soluble
- form
- crystalline
- pka
- pKa1 2.7; pKa2 9.9(at 25℃)
- color
- white
- Water Solubility
- Soluble in water (<1 mg/ml) at 25°C, Acetic acid (49.00-51.00 mg/ml), DMSO (43 mg/ml) at 25°C, ethanol (<1 mg/ml) at 25°C, 0.1 N Sodium hydroxide (1% w/v), methanol (slightly), and dilute aqueous hydrochloric acid or sodium hydroxide (freely).
- Decomposition
- 269-271 ºC
- Merck
- 14,5311
- BRN
- 21703
- InChIKey
- QANMHLXAZMSUEX-UHFFFAOYSA-N
- LogP
- 1.200 (est)
- CAS DataBase Reference
- 525-79-1(CAS DataBase Reference)
- NIST Chemistry Reference
- Kinetin(525-79-1)
- EPA Substance Registry System
- Kinetin (525-79-1)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 68-36/37/38
- Safety Statements
- 23-24/25-22-36/37/39-27-26
- WGK Germany
- 3
- RTECS
- AU6270000
- Hazard Note
- Irritant
- TSCA
- Yes
- HS Code
- 29349990
- Hazardous Substances Data
- 525-79-1(Hazardous Substances Data)
- Toxicity
- LD50 intraperitoneal in mouse: 450mg/kg
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- 48130
- Product name
- Kinetin
- Purity
- ≥99.0% (HPLC)
- Packaging
- 250mg
- Price
- $30.6
- Updated
- 2024/03/01
- Product number
- 48130
- Product name
- Kinetin
- Purity
- ≥99.0% (HPLC)
- Packaging
- 1g
- Price
- $91.4
- Updated
- 2024/03/01
- Product number
- 48130
- Product name
- Kinetin
- Purity
- ≥99.0% (HPLC)
- Packaging
- 5G
- Price
- $289
- Updated
- 2024/03/01
- Product number
- F7182
- Product name
- Fibroblast Activation Protein α human
- Purity
- recombinant, expressed in Sf21 cells, ≥95% (SDS-PAGE)
- Packaging
- 10μG
- Price
- $526
- Updated
- 2023/06/20
- Product number
- K0009
- Product name
- Kinetin
- Packaging
- 1G
- Price
- $33
- Updated
- 2024/03/01
Kinetin Chemical Properties,Usage,Production
Description
Kinetin (or Vivakin) was introduced as Kinerase in the US as a new ingredient for the treatment of age related photodamage of skin. This 6- furfurylaminopurine is a synthetic cytokinin, a family of plant growth factors, and was shown to be a highly potent growth factor. In vitro, it was able to delay or prevent the onset of age-related changes in skin cells without affecting cellular lifespan. In a double-blind clinical trial, Kinetin (0.005%) partially reversed the clinical signs of photodamaged skin and demonstrated a good safety profile. It could have potential in psoriasis as well as in other proliferative skin disorders.
Description
Kinetin is a cytokinin plant growth regulator with diverse biological activities. Kinetin (0.23 μM) increases p34cdc2-like histone H1 kinase activity, the number of cells in mitosis, and total cell number in arrested N. plumbaginifolia cells. It increases GSH levels and activity of glutathione peroxidase and glutathione reductase, but reduces thiobarbituric acid reactive substances (TBARS) levels, in human skin fibroblasts when used at a concentration of 10 μM. Kinetin (40 μM) reduces age-related enlargement, multinucleation, and accumulation of cellular debris in human mammary skin fibroblasts without affecting proliferative lifespan.
Chemical Properties
White Solid
Originator
Senetek (UK)
Uses
Kinetin acts as plant growth accelerator, auxin, plant growth regulator, plant cell division promotor. It also acts as cell division factor found in various plant parts and in yeast. A plant growth regulator. Augments growth of microbial cultures.
Uses
A cell division factor found in various plant parts and in yeast. A plant growth regulator. Augments growth of microbial cultures
Uses
Plant growth regulator. To augment growth of microbial cultures: BE 632589 (1963 to Hoechst).
Definition
ChEBI: Kinetin is a member of the class of 6-aminopurines that is adenine carrying a (furan-2-ylmethyl) substituent at the exocyclic amino group. It has a role as a geroprotector and a cytokinin. It is a member of furans and a member of 6-aminopurines.
brand name
Kinerase
Synthesis Reference(s)
The Journal of Organic Chemistry, 21, p. 1276, 1956 DOI: 10.1021/jo01117a016
General Description
Kinetin is an artificial?cytokinin, obtained from herring sperm. It is named due to its ability to stimulate cell division.
Biochem/physiol Actions
FAPα has in vitro dipeptidyl peptidase activity and collagenolytic activity. It cleaves N-terminal dipeptides from polypeptides and can degrade gelatin and type I collagen. It has also been reported that FAPa has a tumor suppressor activity.
Purification Methods
It forms platelets from EtOH and sublimes at 220o, but is best done at lower temperatures in a good vacuum. It has been extracted from neutral aqueous solutions with Et2O. [Miller et al J Am Chem Soc 78 1375 1956, Bullock et al. J Am Chem Soc 78 3693 1956, Beilstein 26 III/IV 3586.]
Kinetin Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Kinetin manufacturers
- Product
- Kinetin 525-79-1
- Price
- US $3.50/kg
- Min. Order
- 1kg
- Purity
- ≥99%
- Supply Ability
- 3000tons/month
- Release date
- 2024-08-16
- Product
- Kinetin 525-79-1
- Price
- US $3.50/kg
- Min. Order
- 1kg
- Purity
- ≥99%
- Supply Ability
- 3000tons/month
- Release date
- 2024-08-16
- Product
- Kinetin 525-79-1
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20ton
- Release date
- 2024-05-23