ChemicalBook > CAS DataBase List > 5-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID METHYL ESTER

5-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID METHYL ESTER

Product Name
5-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID METHYL ESTER
CAS No.
23170-45-8
Chemical Name
5-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID METHYL ESTER
Synonyms
Methyl 3-Methylpyrazole-4-carboxylate;Methyl 3-methyl-1H-pyrazol-4-carboxylate;Methyl 5-Methyl-1H-pyrazole-4-carboxylate;Methyl 3-Methyl-1H-pyrazole-4-carboxylate;5-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID METHYL ESTER;1H-Pyrazole-4-carboxylic acid, 3-methyl-, methyl ester;3-Cyclopentyl-1H-pyrazole-4-carboxylic acid methyl ester
CBNumber
CB0759096
Molecular Formula
C6H8N2O2
Formula Weight
140.14
MOL File
23170-45-8.mol
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5-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID METHYL ESTER Property

Boiling point:
268.5±20.0 °C(Predicted)
Density 
1.217±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
pka
12.15±0.50(Predicted)
Appearance
Light yellow to yellow Solid
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Safety

HS Code 
2933199090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Matrix Scientific
Product number
073761
Product name
Methyl 3-methyl-1H-pyrazole-4-carboxylate
Purity
95+%
Packaging
250mg
Price
$184
Updated
2021/12/16
Apolloscientific
Product number
OR926793
Product name
Methyl3-methyl-1H-pyrazole-4-carboxylate
Purity
95%
Packaging
5g
Price
$385
Updated
2021/12/16
Matrix Scientific
Product number
073761
Product name
Methyl 3-methyl-1H-pyrazole-4-carboxylate
Purity
95+%
Packaging
1g
Price
$415
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0376337
Product name
METHYL-3-METHYL-1H-PYRAZOLE-4-CARBOXYLATE
Purity
95.00%
Packaging
5MG
Price
$503.57
Updated
2021/12/16
Matrix Scientific
Product number
073761
Product name
Methyl 3-methyl-1H-pyrazole-4-carboxylate
Purity
95+%
Packaging
5g
Price
$1208
Updated
2021/12/16
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5-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID METHYL ESTER Chemical Properties,Usage,Production

Uses

methyl 3-methyl-1h-pyrazole-4-carboxylate is used in the preparation of triazines and their phosphorus analogs via cyclization, ring transformation, aromatization, and substituent modification.

Synthesis

67-56-1

40704-11-8

23170-45-8

General procedure for the synthesis of ethyl 3-methyl-1H-pyrazole-4-carboxylate from methanol and 3-methylpyrazole-4-carboxylic acid: 3-methylpyrazole-4-carboxylic acid (1.26 g, 10 mmol) was dissolved in methanol (100 mL) at 0 °C and thionyl chloride (5.73 g, 45 mmol) was added slowly, the reaction mixture was stirred at room temperature for 12 hours. After completion of the reaction, the solvent was removed by vacuum evaporation. The residue was neutralized by adding saturated aqueous sodium bicarbonate solution and the mixture was extracted with ethyl acetate (100 mL x 3). The organic phases were combined, dried with anhydrous sodium sulfate, filtered and the filtrate was concentrated in vacuum to give ethyl 3-methyl-1H-pyrazole-4-carboxylate (0.8 g, 57% yield). The product was characterized by 1H NMR (300 MHz, CDCl3): δ 7.87 (s, 1H), 3.84 (s, 3H), 2.53 (s, 3H).

References

[1] Patent: WO2013/120104, 2013, A2. Location in patent: Paragraph 00183; 00184
[2] Bioorganic and Medicinal Chemistry Letters, 2015, vol. 25, # 17, p. 3644 - 3649
[3] Advanced Synthesis and Catalysis, 2010, vol. 352, # 11-12, p. 2041 - 2049

5-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID METHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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5-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID METHYL ESTER Suppliers

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23170-45-8, 5-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID METHYL ESTERRelated Search:

ETHYL 5-METHYL-1-PHENYL-1H-PYRAZOLE-4-CARBOXYLATE ETHYL 2-(4-NITROPHENYL)-3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE ETHYL 1,3,5-TRIMETHYL-1H-PYRAZOLE-4-CARBOXYLATE ETHYL 2-PHENYL-3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE ETHYL 3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE ETHYL 1-(4-CHLOROPHENYL)-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLATE ETHYL 2-(4-FLUOROPHENYL)-3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE ETHYL 1-(4-CHLOROPHENYL)-5-PROPYL-1H-PYRAZOLE-4-CARBOXYLATE METHYL 5-ISOXAZOL-5-YL-3-METHYL-1H-PYRAZOLE-4-CARBOXYLATE METHYL 3-METHYL-5-(5-METHYLISOXAZOL-3-YL)-1H-PYRAZOLE-4-CARBOXYLATE ETHYL 1-PHENYL-5-PROPYL-1H-PYRAZOLE-4-CARBOXYLATE METHYL 5-METHYL-1-PHENYLPYRAZOLE-4-CARBOXYLATE ETHYL 3,5-DIMETHYL-1H-4-PYRAZOLECARBOXYLATE ETHYL 1-(2,4-DIFLUOROPHENYL)-5-METHYLPYRAZOLE-4-CARBOXYLATE ETHYL 1-(4-[(2-CHLOROACETYL)AMINO]PHENYL)-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLATE ETHYL 1-(4-AMINOPHENYL)-3,5-DIMETHYL-1H-PYRAZOLE-4-CARBOXYLATE ETHYL 1-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]-5-METHYL-1H-PYRAZOLE-4-CARBOXYLATE ETHYL 1-(6-CHLOROPYRIDAZIN-3-YL)-5-METHYL-1H-PYRAZOLE-4-CARBOXYLATE

  • 5-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID METHYL ESTER
  • Methyl 3-Methyl-1H-pyrazole-4-carboxylate
  • Methyl 5-Methyl-1H-pyrazole-4-carboxylate
  • Methyl 3-Methylpyrazole-4-carboxylate
  • 3-Cyclopentyl-1H-pyrazole-4-carboxylic acid methyl ester
  • 1H-Pyrazole-4-carboxylic acid, 3-methyl-, methyl ester
  • Methyl 3-methyl-1H-pyrazol-4-carboxylate
  • 23170-45-8