5-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID METHYL ESTER
- Product Name
- 5-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID METHYL ESTER
- CAS No.
- 23170-45-8
- Chemical Name
- 5-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID METHYL ESTER
- Synonyms
- Methyl 3-Methylpyrazole-4-carboxylate;Methyl 3-methyl-1H-pyrazol-4-carboxylate;Methyl 5-Methyl-1H-pyrazole-4-carboxylate;Methyl 3-Methyl-1H-pyrazole-4-carboxylate;5-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID METHYL ESTER;1H-Pyrazole-4-carboxylic acid, 3-methyl-, methyl ester;3-Cyclopentyl-1H-pyrazole-4-carboxylic acid methyl ester
- CBNumber
- CB0759096
- Molecular Formula
- C6H8N2O2
- Formula Weight
- 140.14
- MOL File
- 23170-45-8.mol
5-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID METHYL ESTER Property
- Boiling point:
- 268.5±20.0 °C(Predicted)
- Density
- 1.217±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 12.15±0.50(Predicted)
- Appearance
- Light yellow to yellow Solid
Safety
- HS Code
- 2933199090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 073761
- Product name
- Methyl 3-methyl-1H-pyrazole-4-carboxylate
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $184
- Updated
- 2021/12/16
- Product number
- OR926793
- Product name
- Methyl3-methyl-1H-pyrazole-4-carboxylate
- Purity
- 95%
- Packaging
- 5g
- Price
- $385
- Updated
- 2021/12/16
- Product number
- 073761
- Product name
- Methyl 3-methyl-1H-pyrazole-4-carboxylate
- Purity
- 95+%
- Packaging
- 1g
- Price
- $415
- Updated
- 2021/12/16
- Product number
- CHM0376337
- Product name
- METHYL-3-METHYL-1H-PYRAZOLE-4-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $503.57
- Updated
- 2021/12/16
- Product number
- 073761
- Product name
- Methyl 3-methyl-1H-pyrazole-4-carboxylate
- Purity
- 95+%
- Packaging
- 5g
- Price
- $1208
- Updated
- 2021/12/16
5-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID METHYL ESTER Chemical Properties,Usage,Production
Uses
methyl 3-methyl-1h-pyrazole-4-carboxylate is used in the preparation of triazines and their phosphorus analogs via cyclization, ring transformation, aromatization, and substituent modification.
Synthesis
67-56-1
40704-11-8
23170-45-8
General procedure for the synthesis of ethyl 3-methyl-1H-pyrazole-4-carboxylate from methanol and 3-methylpyrazole-4-carboxylic acid: 3-methylpyrazole-4-carboxylic acid (1.26 g, 10 mmol) was dissolved in methanol (100 mL) at 0 °C and thionyl chloride (5.73 g, 45 mmol) was added slowly, the reaction mixture was stirred at room temperature for 12 hours. After completion of the reaction, the solvent was removed by vacuum evaporation. The residue was neutralized by adding saturated aqueous sodium bicarbonate solution and the mixture was extracted with ethyl acetate (100 mL x 3). The organic phases were combined, dried with anhydrous sodium sulfate, filtered and the filtrate was concentrated in vacuum to give ethyl 3-methyl-1H-pyrazole-4-carboxylate (0.8 g, 57% yield). The product was characterized by 1H NMR (300 MHz, CDCl3): δ 7.87 (s, 1H), 3.84 (s, 3H), 2.53 (s, 3H).
References
[1] Patent: WO2013/120104, 2013, A2. Location in patent: Paragraph 00183; 00184
[2] Bioorganic and Medicinal Chemistry Letters, 2015, vol. 25, # 17, p. 3644 - 3649
[3] Advanced Synthesis and Catalysis, 2010, vol. 352, # 11-12, p. 2041 - 2049
5-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID METHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
5-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID METHYL ESTER Suppliers
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