NECA

Product Name: NECA
CAS No.: 35920-39-9
Chemical Name: NECA
Synonyms: NECA;D-NECA;744-96;765-21;B-744-96;NECA USP/EP/BP;NECA, adenosine agonist;5'-ETHYLCARBOXAMIDOADENOSINE;5’-EthylcarboxamidoAdenosine;Adenosine-5'-ethylcarboxamide
CBNumber: CB0763077
Molecular Formula: C12H16N6O4
Formula Weight: 308.29
MOL File: 35920-39-9.mol

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NECA Property

Melting point:: 229-231°C
Density: 1.87±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.2 mg/mL Solutions may be stored for several days at 4°C.
pka: 12.93±0.70(Predicted)
form: powder
color: white
Stability:: Hygroscopic
InChIKey: JADDQZYHOWSFJD-FLNNQWSLSA-N
CAS DataBase Reference: 35920-39-9

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Safety

Hazard Codes: T+
Risk Statements: 28
Safety Statements: 22-26-36-45
RIDADR: UN 2811 6.1/PG 2
WGK Germany: 3
RTECS: VJ2232000
HazardClass: 6.1(a)
PackingGroup: I
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H300Fatal if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: E2387
Product name: 5′-(N-Ethylcarboxamido)adenosine
Purity: powder
Packaging: 50mg
Price: $223
Updated: 2024/03/01

Sigma-Aldrich

Product number: 119140
Product name: Adenosine Receptor Agonist, NECA
Packaging: 10mg
Price: $69
Updated: 2024/03/01

Alfa Aesar

Product number: J60405
Product name: 5'-N-Ethylcarboxamidoadenosine
Packaging: 10mg
Price: $83
Updated: 2021/12/16

Alfa Aesar

Product number: J60405
Product name: 5'-N-Ethylcarboxamidoadenosine
Packaging: 50mg
Price: $351
Updated: 2021/12/16

Cayman Chemical

Product number: 21420
Product name: 5'-N-Ethylcarboxamidoadenosine
Purity: ≥99%
Packaging: 5mg
Price: $25
Updated: 2021/12/16

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NECA Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

A potent adenosine receptor agonist. Inhibits platelet aggregation and is centrally active in vivo

Uses

Potent adenosine receptor agonist with some affinity at A1 and A2 receptors

Uses

5′-(N-Ethylcarboxamido)adenosine has been used:

for the purification of human adenosine A_2Areceptor (A_2AR) in decylmaltoside (DM)
to determine nonspecific binding of adenosine receptors
to investigate adenosine 2B receptor (RA2B) mechanism of action by competition assay

Definition

ChEBI: A derivative of adenosine in which the 5'-hydroxymethyl group is replaced by an N-ethylcarboxamido group.

General Description

A cell-permeable adenosine analog that acts a potent non-selective agonist of adenosine receptors (K_i = 14 nM, 20 nM, 2.4 μM and 6.2 nM for A₁, A_2A, A_2B, A₃, respectively). Increases intracellular cAMP production (EC₅₀ = 3.1 μM in A_2B expressing CHO cells). Shown to increase glucagon release in a dose-dependent manner and inhibit insulin release at low concentrations. Although at higher concentration some insulin release is observed. Also, displays a wide range adenosine-dependent effects, such as blocking platelet aggregation and inhibiting DNA synthesis. When administered at reperfusion, it is shown reduce infarction and block the formation of the mitochondrial permeability transition pore by activating p70S6 kinase.

Biological Activity

Potent adenosine receptor agonist (K i values are 14, 20 and 6.2 nM for human A 1 , A 2A and A 3 receptors respectively; EC 50 = 2.4 μ M for human A 2B ). Inhibits platelet aggregation and is centrally active in vivo .

Biochem/physiol Actions

Reversible: yes

storage

Store at +4°C

NECA Preparation Products And Raw materials

Raw materials

Preparation Products

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NECA Suppliers

Canada 1 China 76 China Hong Kong 1 Germany 2 India 1 Russia 1 South Korea 1 Switzerland 1 United Kingdom 4 United States 17 Global 105

EMMX Biotechnology LLC

Tel: 888-539-0666
Fax: 888-539-0666
Email: info@emmx.com
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TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32161
Advantage: 58

BOC Sciences

Tel: 16314854226
Fax: 1-631-614-7828
Email: inquiry@bocsci.com
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ProdList: 9713
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BOC Sciences

Tel: +1-631-485-4226
Fax: 1-631-614-7828
Email: inquiry@bocsci.com
Country: United States
ProdList: 19553
Advantage: 58

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

TargetMol Chemicals Inc.

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ProdList: 38631
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ApexBio Technology

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Abblis Chemicals LLC

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Abcam

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United States Biological

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ProdList: 6214
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Cayman Chemical Company

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Country: United States
ProdList: 6213
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Riedel-de Haen AG

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ProdList: 6773
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Labseeker Inc

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Santa Cruz Biotechnology, Inc.

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Country: United States
ProdList: 3597
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3B Scientific Corporation

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ASDI Incorporated

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MP Biomedicals, Inc.

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View Lastest Price from NECA manufacturers

Career Henan Chemical Co

Product: NECA 35920-39-9
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: JD 562
Release date: 2019-09-01

35920-39-9, NECARelated Search:

he-neca 2-IODO-NECA 5'-EthylcarboxaMido-2',3'-isopropylidene Adenosine 2-Chloro-NECA NECA 5'-N-[ADENINE-2,8-3H]- N6-BENZYL-NECA CGS 21680, [CARBOXYETHYL-3H(N)]- 2-CHLORO-2',3'-O-ISOPROPYLIDENEADENOSINE-5'-N-ETHYLCARBOXAMIDE EB-47 DIHYDROCHLORIDE DIHYDRATE CGS 21680 NECA 5'-(N-CYCLOPROPYL)CARBOXAMIDOADENOSINE DANSYL-NECA 5'-N-ETHYLCARBOXAMIDOADENOSINE, [ADENINE-2,8-3H]- CGS-21680 HYDROCHLORIDE

5'-N6-Ethylcarboxamidoadenosine

5'-ETHYLCARBOXAMIDOADENOSINE

1-(6-AMINO-9H-PURIN-9-YL)-1-DEOXY-N-ETHYL-BETA-D-RIBOFURANURONAMIDE

1-(6-amino-9h-purin-9-yl)-1-deoxy-n-ethylribofuranuronamidehemihydrate

1-(6-amino-9h-purin-9-yl)-1-deoxy-n-ethyl-ribofuranuronamidhemihydrate

5’-n(sup6)-ethylcarboxamidoadenosinehemihydrate

5’-n-ethylcarboxamidoadenosinehemihydrate

adenosine-5’-(n-ethyl)carboxamidehemihydrate

adenosine-5’-(n-ethylcarboxamide

NECA

b-D-RibofuranuronaMide, 1-(6-aMino-9H-purin-9-yl)-1-deoxy-N-ethyl-

D-NECA

NECA,5′-(N-Ethylcarboxamido)adenosine

Adenosine Receptor Agonist, NECA

5'-(N-ETHYLCARBOXAMIDO)-ADENOSINE

1-(6-Amino-(9H)-purin-9-yl)-1-deoxy-N-ethyl-b-D-ribofuranuronamide

NECA, 1-(6-Amino-9H-purin-9-yl)-1-deoxy-N-ethyl-D-ribofuranuronamide

5'-Ethylcarboxamido-D-adenosine

5'-N-Ethylcarboxamideadenosine

744-96

765-21

Adenosine-5'-ethylcarboxamide

B-744-96

1-(6-Amino-9H-purin-9-yl)-1-deoxy-N-ethyl-β-D-ribofuranuronamide

N-ethyl-5'-carboxamidoadenosine

Adenosine Receptor Agonist, NECA - CAS 35920-39-9 - Calbiochem

β-D-Ribofuranuronamide, 1-(6-amino-9H-purin-9-yl)-1-deoxy-N-ethyl-

NECA USP/EP/BP

1-(6-Amino-9H-purin-9-yl)-1-deoxy-N-ethyl-β-D-ribofuranuronamide

5’-EthylcarboxamidoAdenosine

5'-N-Ethylcarboxamidoadenosine

5'-N-Ethylcarboxamidoadenosine (NECA)

(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,4-dihydroxytetrahydrofuran-2-carboxamide

NECA, adenosine agonist

35920-39-9

C12H16N6O4

Potent adenosine receptor agonist with nearly equal affinity at A1 and A2 receptors.

Bases & Related Reagents

Inhibitors

Nucleotides

Adenosine receptor