NIKKOMYCIN Z

Product Name: NIKKOMYCIN Z
CAS No.: 59456-70-1
Chemical Name: NIKKOMYCIN Z
Synonyms: NIKKOMYCIN;huaguamycin;neopolyoxinc;NIKKOMYCIN Z;(2s-(2r*,3r*,4r*))-l);NIKKOMYCIN Z, STREPTOMYCES TENDAE;Nikkomycin Z, Sterptomyces tendae;nikkomycin Z from streptomyces tendae;5-((2-amino-4-hydroxy-4-(5-hydroxy-2-pyridinyl)-3-beta-d-allofuranuronicaci;5-((2-Amino-4-hydroxy-4-(5-hydroxy-2-pyridinyl)-3-beta-d-allofuranuronicacid
CBNumber: CB0767000
Molecular Formula: C20H25N5O10
Formula Weight: 495.44
MOL File: 59456-70-1.mol

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NIKKOMYCIN Z Property

Density: 1.646±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: H2O: soluble5mg/mL
pka: 2.70±0.10(Predicted)
form: Solid
color: White to off-white
Water Solubility: Water : ≥ 100 mg/mL (201.84 mM)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
RTECS: BA2928200
F: 10

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: N8028
Product name: Nikkomycin Z from Streptomyces tendae
Purity: ≥90% (HPLC)
Packaging: 5mg
Price: $437
Updated: 2024/03/01

AK Scientific

Product number: X6882
Product name: Nikkomycin Z from Streptomyces tendae
Packaging: 5mg
Price: $460
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0012075
Product name: NIKKOMYCIN
Purity: 95.00%
Packaging: 5MG
Price: $502.55
Updated: 2021/12/16

AHH

Product number: MT-56998
Product name: NikkomycinZ
Purity: 98%
Packaging: 0.005g
Price: $330
Updated: 2021/12/16

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NIKKOMYCIN Z Chemical Properties,Usage,Production

Description

Nucleoside-type antibiotic isolated from culture filtrates of Streptomyces tendae (19). Some analogs were also prepared by mutasynthesis, utilizing a uracil auxotroph of S. tendae.

Uses

Nikkomycins inhibit the growth of various plant pathogenic fungi but are inactive against bacteria and yeasts. Too susceptible to photodegradation by sunlight to be used in field application, and thus not developed commercially for agricultural use. Among the nikkomycins, nikkomycin Z is an orally active antifungal therapeutic agent for coccidioidomycosis. It is a competitive chitin synthase inhibitor that has been evaluated in mouse models for coccidioidomycosis.

Definition

ChEBI: A uridine-based nucleoside-peptide antibiotic which inhibits fungal chitin biosynthesis by inhibiting chitin synthase.

Pharmacology

By inhibiting chitin synthetase in fungi, nikkomycins inhibit cell wall synthesis, ultimately causing fungal cells to swell and burst.

Metabolism

There are no detailed reports on metabolism/transformation of nikkomycins in the environment.

NIKKOMYCIN Z Preparation Products And Raw materials

Raw materials

Preparation Products

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NIKKOMYCIN Z Suppliers

China 23 Japan 1 South Korea 1 Switzerland 1 United Kingdom 4 United States 10 Global 40

BOC Sciences

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Finetech Industry Limited

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Shanghai Synchem Pharma Co., ltd

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Beijing OKA biological technology co., LTD

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AFINE CHEMICALS LIMITED

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Wuhan Rongcan Biotechnology Co., Ltd

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Zhejiang Huida Biotech Co., LTD

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Zhejiang Huida Biotech Co., LTD

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59456-70-1, NIKKOMYCIN ZRelated Search:

NIKKOMYCIN Z PROPYL-(TETRAHYDRO-FURAN-2-YLMETHYL)-AMINE D-HOMOCITRULLINE (S)-(+)-Tetrahydrofurfurylamine GLYCYL-D-THREONINE DIHYDRATE AC-D-NLE-OH GLYCYL-D-SERINE (2R,3S)-2-AMINO-3-HYDROXY-HEXANOIC ACID 4-PYRIDIN-2-YL-BUTYLAMINE Nikkomycin M dl-3-hydroxynorvaline AC-D-LYS-OH GLYCYL-D-THREONINE Nikkomycin N Nikkomycin J Nikkomycin pseudo-J nikkomycin L(z) nikkomycin L(x)

NIKKOMYCIN

NIKKOMYCIN Z

NIKKOMYCIN Z, STREPTOMYCES TENDAE

(2s-(2r*,3r*,4r*))-l)

5-((2-amino-4-hydroxy-4-(5-hydroxy-2-pyridinyl)-3-beta-d-allofuranuronicaci

methyl-1-oxobutyl)amino)-1,5-dideoxy-1-(3,4-dihydro-2,4-dioxo-1(2h)-pyrimidiny

neopolyoxinc

nikkomycin Z from streptomyces tendae

Nikkomycin Z, Sterptomyces tendae

5-[[(2S,3S,4S)-2-Amino-4-hydroxy-4-(5-hydroxy-2-pyridinyl)-3-methyl-1-oxobutyl]amino]-1-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-1,5-dideoxy-β-D-allofuranuronic acid

5-[[(2S,3S,4S)-2-Amino-4-hydroxy-4-(5-hydroxy-2-pyridinyl)-3-methyl-1-oxobutyl]amino]-1-(3,4-dihydro-2,4-dioxopyrimidin-1(2H)-yl)-1,5-dideoxy-β-D-allofuranuronic acid

5-((2-Amino-4-hydroxy-4-(5-hydroxy-2-pyridinyl)-3-beta-d-allofuranuronicacid

β-D-Allofuranuronic acid, 5-[[(2S,3S,4S)-2-amino-4-hydroxy-4-(5-hydroxy-2-pyridinyl)-3-methyl-1-oxobutyl]amino]-1,5-dideoxy-1-(3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)-

huaguamycin

59456-70-1

C20H25N5O10

BioChemical

Antibiotics

Antibiotics A to Z

Antibiotics N-S

AntifungalGlycobiology

InhibitorsAntibiotics

Peptidyl NucleosidesMore...Close...

Inhibitors and Substrates

Peptidyl Nucleosides

Antibiotics

Antibiotics A to

Antibiotics N-SAntibiotics

AntifungalAntibiotics

Chemical Structure Class

Inhibits an EnzymeAntibiotics

Interferes with Cell Wall SynthesisAntibiotics

Mechanism of Action

Spectrum of Activity