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NIKKOMYCIN Z

Product Name
NIKKOMYCIN Z
CAS No.
59456-70-1
Chemical Name
NIKKOMYCIN Z
Synonyms
NIKKOMYCIN;huaguamycin;neopolyoxinc;NIKKOMYCIN Z;(2s-(2r*,3r*,4r*))-l);NIKKOMYCIN Z, STREPTOMYCES TENDAE;Nikkomycin Z, Sterptomyces tendae;nikkomycin Z from streptomyces tendae;5-((2-amino-4-hydroxy-4-(5-hydroxy-2-pyridinyl)-3-beta-d-allofuranuronicaci;5-((2-Amino-4-hydroxy-4-(5-hydroxy-2-pyridinyl)-3-beta-d-allofuranuronicacid
CBNumber
CB0767000
Molecular Formula
C20H25N5O10
Formula Weight
495.44
MOL File
59456-70-1.mol
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NIKKOMYCIN Z Property

Density 
1.646±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
H2O: soluble5mg/mL
pka
2.70±0.10(Predicted)
Water Solubility 
Water : ≥ 100 mg/mL (201.84 mM)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
RTECS 
BA2928200
F 
10
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
N8028
Product name
Nikkomycin Z from Streptomyces tendae
Purity
≥90% (HPLC)
Packaging
5mg
Price
$437
Updated
2024/03/01
AK Scientific
Product number
X6882
Product name
Nikkomycin Z from Streptomyces tendae
Packaging
5mg
Price
$460
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0012075
Product name
NIKKOMYCIN
Purity
95.00%
Packaging
5MG
Price
$502.55
Updated
2021/12/16
AHH
Product number
MT-56998
Product name
NikkomycinZ
Purity
98%
Packaging
0.005g
Price
$330
Updated
2021/12/16
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NIKKOMYCIN Z Chemical Properties,Usage,Production

Description

Nucleoside-type antibiotic isolated from culture filtrates of Streptomyces tendae (19). Some analogs were also prepared by mutasynthesis, utilizing a uracil auxotroph of S. tendae.

Uses

Nikkomycins inhibit the growth of various plant pathogenic fungi but are inactive against bacteria and yeasts. Too susceptible to photodegradation by sunlight to be used in field application, and thus not developed commercially for agricultural use. Among the nikkomycins, nikkomycin Z is an orally active antifungal therapeutic agent for coccidioidomycosis. It is a competitive chitin synthase inhibitor that has been evaluated in mouse models for coccidioidomycosis.

Definition

ChEBI: A uridine-based nucleoside-peptide antibiotic which inhibits fungal chitin biosynthesis by inhibiting chitin synthase.

Pharmacology

By inhibiting chitin synthetase in fungi, nikkomycins inhibit cell wall synthesis, ultimately causing fungal cells to swell and burst.

Metabolism

There are no detailed reports on metabolism/transformation of nikkomycins in the environment.

NIKKOMYCIN Z Preparation Products And Raw materials

Raw materials

Preparation Products

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NIKKOMYCIN Z Suppliers

China 20 Japan 1 South Korea 1 Switzerland 1 United Kingdom 4 United States 10 Global 37

59456-70-1, NIKKOMYCIN ZRelated Search:

NIKKOMYCIN Z PROPYL-(TETRAHYDRO-FURAN-2-YLMETHYL)-AMINE D-HOMOCITRULLINE (S)-(+)-Tetrahydrofurfurylamine GLYCYL-D-THREONINE DIHYDRATE AC-D-NLE-OH GLYCYL-D-SERINE (2R,3S)-2-AMINO-3-HYDROXY-HEXANOIC ACID 4-PYRIDIN-2-YL-BUTYLAMINE Nikkomycin M dl-3-hydroxynorvaline AC-D-LYS-OH GLYCYL-D-THREONINE Nikkomycin N Nikkomycin J Nikkomycin pseudo-J nikkomycin L(z) nikkomycin L(x)

  • NIKKOMYCIN
  • NIKKOMYCIN Z
  • NIKKOMYCIN Z, STREPTOMYCES TENDAE
  • (2s-(2r*,3r*,4r*))-l)
  • 5-((2-amino-4-hydroxy-4-(5-hydroxy-2-pyridinyl)-3-beta-d-allofuranuronicaci
  • methyl-1-oxobutyl)amino)-1,5-dideoxy-1-(3,4-dihydro-2,4-dioxo-1(2h)-pyrimidiny
  • neopolyoxinc
  • nikkomycin Z from streptomyces tendae
  • Nikkomycin Z, Sterptomyces tendae
  • 5-[[(2S,3S,4S)-2-Amino-4-hydroxy-4-(5-hydroxy-2-pyridinyl)-3-methyl-1-oxobutyl]amino]-1-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-1,5-dideoxy-β-D-allofuranuronic acid
  • 5-[[(2S,3S,4S)-2-Amino-4-hydroxy-4-(5-hydroxy-2-pyridinyl)-3-methyl-1-oxobutyl]amino]-1-(3,4-dihydro-2,4-dioxopyrimidin-1(2H)-yl)-1,5-dideoxy-β-D-allofuranuronic acid
  • 5-((2-Amino-4-hydroxy-4-(5-hydroxy-2-pyridinyl)-3-beta-d-allofuranuronicacid
  • β-D-Allofuranuronic acid, 5-[[(2S,3S,4S)-2-amino-4-hydroxy-4-(5-hydroxy-2-pyridinyl)-3-methyl-1-oxobutyl]amino]-1,5-dideoxy-1-(3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)-
  • huaguamycin
  • 59456-70-1
  • C20H25N5O10
  • BioChemical
  • Antibiotics
  • Antibiotics A to Z
  • Antibiotics N-S
  • AntifungalGlycobiology
  • InhibitorsAntibiotics
  • Peptidyl NucleosidesMore...Close...
  • Inhibitors and Substrates
  • Peptidyl Nucleosides
  • Antibiotics
  • Antibiotics A to
  • Antibiotics N-SAntibiotics
  • AntifungalAntibiotics
  • Chemical Structure Class
  • Inhibits an EnzymeAntibiotics
  • Interferes with Cell Wall SynthesisAntibiotics
  • Mechanism of Action
  • Spectrum of Activity