NIKKOMYCIN Z
- Product Name
- NIKKOMYCIN Z
- CAS No.
- 59456-70-1
- Chemical Name
- NIKKOMYCIN Z
- Synonyms
- NIKKOMYCIN;huaguamycin;neopolyoxinc;NIKKOMYCIN Z;(2s-(2r*,3r*,4r*))-l);NIKKOMYCIN Z, STREPTOMYCES TENDAE;Nikkomycin Z, Sterptomyces tendae;nikkomycin Z from streptomyces tendae;5-((2-amino-4-hydroxy-4-(5-hydroxy-2-pyridinyl)-3-beta-d-allofuranuronicaci;5-((2-Amino-4-hydroxy-4-(5-hydroxy-2-pyridinyl)-3-beta-d-allofuranuronicacid
- CBNumber
- CB0767000
- Molecular Formula
- C20H25N5O10
- Formula Weight
- 495.44
- MOL File
- 59456-70-1.mol
NIKKOMYCIN Z Property
- Density
- 1.646±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- H2O: soluble5mg/mL
- pka
- 2.70±0.10(Predicted)
- Water Solubility
- Water : ≥ 100 mg/mL (201.84 mM)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- N8028
- Product name
- Nikkomycin Z from Streptomyces tendae
- Purity
- ≥90% (HPLC)
- Packaging
- 5mg
- Price
- $437
- Updated
- 2024/03/01
- Product number
- X6882
- Product name
- Nikkomycin Z from Streptomyces tendae
- Packaging
- 5mg
- Price
- $460
- Updated
- 2021/12/16
- Product number
- API0012075
- Product name
- NIKKOMYCIN
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $502.55
- Updated
- 2021/12/16
- Product number
- MT-56998
- Product name
- NikkomycinZ
- Purity
- 98%
- Packaging
- 0.005g
- Price
- $330
- Updated
- 2021/12/16
NIKKOMYCIN Z Chemical Properties,Usage,Production
Description
Nucleoside-type antibiotic isolated from culture filtrates of Streptomyces tendae (19). Some analogs were also prepared by mutasynthesis, utilizing a uracil auxotroph of S. tendae.
Uses
Nikkomycins inhibit the growth of various plant pathogenic fungi but are inactive against bacteria and yeasts. Too susceptible to photodegradation by sunlight to be used in field application, and thus not developed commercially for agricultural use. Among the nikkomycins, nikkomycin Z is an orally active antifungal therapeutic agent for coccidioidomycosis. It is a competitive chitin synthase inhibitor that has been evaluated in mouse models for coccidioidomycosis.
Definition
ChEBI: A uridine-based nucleoside-peptide antibiotic which inhibits fungal chitin biosynthesis by inhibiting chitin synthase.
Pharmacology
By inhibiting chitin synthetase in fungi, nikkomycins inhibit cell wall synthesis, ultimately causing fungal cells to swell and burst.
Metabolism
There are no detailed reports on metabolism/transformation of nikkomycins in the environment.
NIKKOMYCIN Z Preparation Products And Raw materials
Raw materials
Preparation Products
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