2-CHLOROTHIAZOLE-5-CARBONITRILE

Product Name: 2-CHLOROTHIAZOLE-5-CARBONITRILE
CAS No.: 51640-36-9
Chemical Name: 2-CHLOROTHIAZOLE-5-CARBONITRILE
Synonyms: 2-Chloro-5-cyano-1,3-thiazole;2-CHLOROTHIAZOLE-5-CARBONITRILE;2-chloro-5-thiazolecarbonitrile;5-Thiazolecarbonitrile, 2-chloro-;2-Chlorothiazole-5-carbonitrile 97%;2-CHLORO-1,3-THIAZOLE-5-CARBONITRILE;2-Chlorothiazole-5-carbonitrile ,97%;2-CHLOROTHIAZOLE-5-CARBONITRILE, 95+%;2-CHLOROTHIAZOLE-5-CARBONITRILE,2-CHLORO-5-THIAZOLE CARBONITRILE
CBNumber: CB0768209
Molecular Formula: C4HClN2S
Formula Weight: 144.58
MOL File: 51640-36-9.mol

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2-CHLOROTHIAZOLE-5-CARBONITRILE Property

Melting point:: 47-49°
Boiling point:: 291.1±32.0 °C(Predicted)
Density: 1.53±0.1 g/cm3(Predicted)
Flash point:: 104℃
storage temp.: -20°C
pka: -2.28±0.10(Predicted)
form: solid
Appearance: Light yellow to yellow Solid
InChI: InChI=1S/C4HClN2S/c5-4-7-2-3(1-6)8-4/h2H
InChIKey: BAFLVXULMMAKMM-UHFFFAOYSA-N
SMILES: S1C(C#N)=CN=C1Cl

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Safety

Hazard Codes: Xn
Risk Statements: 22-41
Safety Statements: 26
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 2934100090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 720534
Product name: 2-Chlorothiazole-5-carbonitrile
Purity: 97%
Packaging: 1g
Price: $97.7
Updated: 2023/06/20

TRC

Product number: C380553
Product name: 2-Chlorothiazole-5-carbonitrile
Packaging: 500mg
Price: $90
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC139907
Product name: 2-Chlorothiazole-5-carbonitrile
Packaging: 500mg
Price: $60
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC139907
Product name: 2-Chlorothiazole-5-carbonitrile
Packaging: 1g
Price: $90
Updated: 2021/12/16

Matrix Scientific

Product number: 045375
Product name: 2-Chloro-1,3-thiazole-5-carbonitrile
Purity: >95%
Packaging: 1g
Price: $115
Updated: 2021/12/16

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2-CHLOROTHIAZOLE-5-CARBONITRILE Chemical Properties,Usage,Production

Synthesis

51640-52-9

51640-36-9

General procedure for the synthesis of 2-chlorothiazole-5-carbonitrile using 2-amino-5-cyano thiazole as starting material: 3.4 g (27 mmol) of 2-amino-5-cyano thiazole (Example 43) was homogeneously dispersed in 100 mL of acetonitrile with 5.1 g (30 mmol) of copper chloride dihydrate. Under vigorous stirring conditions, 5.7 mL of an acetonitrile solution of isoamyl nitrite was slowly added dropwise over a period of 30 minutes, and the reaction was continued for 10 hours after completion of the dropwise addition. After completion of the reaction, the reaction mixture was concentrated and the residue was dissolved in ethyl acetate and filtered to remove insoluble impurities. The organic phase was concentrated and purified by column chromatography to give 2.6 g of the target product (67% yield) as a liquid. The liquid precipitated needle-like crystals upon standing, with a melting point of 54-57 °C. 13C NMR (CDCl3, ppm) data were as follows: 108.16, 110.41, 150.59, 157.36; mass spectrometry (EI) showed the molecular ion peak m/z of 144.1 (M+).

References

[1] Journal of Medicinal Chemistry, 2004, vol. 47, # 25, p. 6363 - 6372
[2] Patent: EP2039686, 2009, A1. Location in patent: Page/Page column 32-33
[3] Patent: US2010/87448, 2010, A1. Location in patent: Page/Page column 22
[4] Patent: US2004/23978, 2004, A1. Location in patent: Page/Page column 13
[5] Patent: US2004/23980, 2004, A1. Location in patent: Page/Page column 13

2-CHLOROTHIAZOLE-5-CARBONITRILE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-CHLOROTHIAZOLE-5-CARBONITRILE Suppliers

China 73 Germany 1 India 1 United Kingdom 5 United States 13 Global 93

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51640-36-9, 2-CHLOROTHIAZOLE-5-CARBONITRILERelated Search:

2-Chlorothiazole 5-CYANOTHIAZOLE 2-CHLORO-4-TRIFLUOROMETHYL-THIAZOLE-5-CARBONITRILE 2-CHLOROTHIAZOLE-5-CARBONITRILE 2,4-DICHLORO-5-CYANOTHIAZOLE

2-CHLOROTHIAZOLE-5-CARBONITRILE,2-CHLORO-5-THIAZOLE CARBONITRILE

2-CHLOROTHIAZOLE-5-CARBONITRILE, 95+%

2-Chlorothiazole-5-carbonitrile ,97%

2-Chloro-5-cyano-1,3-thiazole

2-CHLOROTHIAZOLE-5-CARBONITRILE

2-CHLORO-1,3-THIAZOLE-5-CARBONITRILE

2-chloro-5-thiazolecarbonitrile

2-Chlorothiazole-5-carbonitrile 97%

5-Thiazolecarbonitrile, 2-chloro-

51640-36-9

C4HClN2S

Thiazole series

Thiazoles, Isothiazoles & Benzothiazoles