MORPHOLIN-4-YL-ACETIC ACID

Uses

Product Name: MORPHOLIN-4-YL-ACETIC ACID
CAS No.: 89531-58-8
Chemical Name: MORPHOLIN-4-YL-ACETIC ACID
Synonyms: 2-Morpholinoacetic acid hydrochloride;EOS-62303;AKOS BBS-00002525;RARECHEM AL BO 0383;TIMTEC-BB SBB010303;MORPHOLINOACETIC ACID;4-MORPHOLINOACETIC ACID;MORPHOLIN-4-YL-ACETIC ACID;4-MORPHOLINACETIC ACID HCL;4-Morpholineacetic acid HCL
CBNumber: CB0773287
Molecular Formula: C6H11NO3
Formula Weight: 145.16
MOL File: 89531-58-8.mol

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MORPHOLIN-4-YL-ACETIC ACID Property

Melting point:: 160-161℃
storage temp.: Inert atmosphere,Room Temperature
form: Powder
color: White
Water Solubility: Insoluble in water.
InChI: InChI=1S/C6H11NO3/c8-6(9)5-7-1-3-10-4-2-7/h1-5H2,(H,8,9)
InChIKey: ICGYBJNONRDZOP-UHFFFAOYSA-N
SMILES: C(O)(=O)CN1CCOCC1
CAS DataBase Reference: 89531-58-8

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Safety

Hazard Codes: Xi
Risk Statements: 36-36/37/38
Safety Statements: 26-36/37/39
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H319Causes serious eye irritation
Precautionary statements: P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: ANV00112
Product name: 2-Morpholinoacetic acid hydrochloride
Purity: AldrichCPR
Packaging: 1G
Price: $259
Updated: 2025/07/31

TCI Chemical

Product number: M2608
Product name: Morpholinoacetic Acid Hydrochloride
Purity: >98.0%(T)
Packaging: 1g
Price: $37
Updated: 2025/07/31

TCI Chemical

Product number: M2608
Product name: Morpholinoacetic Acid Hydrochloride
Purity: >98.0%(T)
Packaging: 5g
Price: $147
Updated: 2025/07/31

TRC

Product number: M722990
Product name: 4-MorpholineaceticAcidHydrochloride
Packaging: 250mg
Price: $70
Updated: 2021/12/16

TRC

Product number: M722990
Product name: 4-MorpholineaceticAcidHydrochloride
Packaging: 10g
Price: $445
Updated: 2021/12/16

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MORPHOLIN-4-YL-ACETIC ACID Chemical Properties,Usage,Production

Uses

4-Morpholineacetic Acid Hydrochloride is an intermediate of Carfilzomib (C183460) which is a second-generation proteasome inhibitor that is used as a treatment in relapsed and refractory multiple myeloma.

Chemical Properties

White solid

Uses

4-Morpholineacetic Acid Hydrochloride is an intermediate of Carfilzomib (C183460) which is a second-generation proteasome inhibitor that is used as a treatment in relapsed and refractory multiple myeloma.

Synthesis

3235-82-3

89531-58-8

The general procedure for the synthesis of morpholine-4-acetic acid hydrochloride from ethyl 2-(4-morpholinyl)acetate is as follows: ethyl 4-morpholinoacetate (1.1 g, 6.3 mmol) was added to 3M hydrochloric acid solution (35 ml) and the reaction was carried out at reflux for 2 hours. After completion of the reaction, the mixture was stirred at room temperature for 24 hours. Subsequently, the reaction solution was concentrated under reduced pressure. The obtained residue was dissolved in methanol and concentrated again under reduced pressure. The final solid product obtained was suspended in ether, separated by filtration and dried under reduced pressure to give 1.05 g of morpholine-4-acetic acid hydrochloride in 91.7% yield. The product was characterized by NMR (DMSO-d6) with chemical shifts of 3.3 (s, 4H), 3.9 (s, 4H), 4.2 (s, 2H).

References

[1] Journal of the American Chemical Society, 2017, vol. 139, # 34, p. 11895 - 11902
[2] Patent: US6352993, 2002, B1. Location in patent: Page column 13
[3] Journal of Molecular Structure, 2001, vol. 560, # 1-3, p. 261 - 273
[4] Patent: US5521179, 1996, A
[5] Bioconjugate Chemistry, 2016, vol. 27, # 1, p. 226 - 237

MORPHOLIN-4-YL-ACETIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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MORPHOLIN-4-YL-ACETIC ACID Suppliers

Americas 1 China 111 Europe 1 France 1 Germany 1 India 9 Japan 1 United Kingdom 4 United States 25 Global 154

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View Lastest Price from MORPHOLIN-4-YL-ACETIC ACID manufacturers

Career Henan Chemical Co

Product: MORPHOLIN-4-YL-ACETIC ACID 89531-58-8
Price: US $1.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 100KG
Release date: 2018-12-21

89531-58-8, MORPHOLIN-4-YL-ACETIC ACIDRelated Search:

MORPHOLIN-2-YL-ACETIC ACID ETHYL ESTER MORPHOLIN-4-YL-ACETIC ACID MORPHOLIN-3-YL-ACETIC ACID ETHYL ESTER HYDROCHLORIDE (S)-Morpholin-3-yl-acetic acid (4-BENZYL-MORPHOLIN-2-YL)-ACETIC ACID HYDROCHLORIDE MORPHOLIN-3-YL-ACETIC ACID HYDROCHLORIDE MORPHOLIN-3-YL-ACETIC ACID METHYL ESTER (4-BENZYL-MORPHOLIN-2-YL)-ACETIC ACID METHYL ESTER (2R,6S)-(2,6-DIMETHYL-MORPHOLIN-4-YL)-ACETIC ACID (R)-(4-BENZYL-MORPHOLIN-3-YL)-ACETIC ACID METHYL ESTER,(R)-(4-Benzyl-morpholin-3-yl)-acetic acid methyl MORPHOLIN-2-YL-ACETIC ACID (4-Benzyl-morpholin-3-yl)-acetic acid methyl ester (5,5-DIMETHYL-MORPHOLIN-2-YL)-ACETIC ACID 2-(4-N-CBZ-MORPHOLIN-2-YL)ACETIC ACID (4-BENZYL-MORPHOLIN-2-YL)-ACETIC ACID (4-METHOXY-PHENYL)-MORPHOLIN-4-YL-ACETIC ACID HYDROCHLORIDE (2-OXO-MORPHOLIN-4-YL)-ACETIC ACID 2-(4-N-FMOC-MORPHOLIN-2-YL)ACETIC ACID

2-(4-Morpholinyl)acetic acid HCl

4-(Carboxymethyl)morpholine hydrochloride

Morpholin-4-yl-aceticacid HCl

4-Morpholinylacetic acid hydrochloride

2-Morpholin-4-ylacetic Acid hydrochloride

4-Morpholineacetic acid HCL

Morpholinoacetic Acid Hydrochloride

MORPHOLINOACETIC ACID

MORPHOLIN-4-YL-ACETIC ACID HYDROCHLORIDE

MORPHOLIN-4-YL-ACETIC ACID

RARECHEM AL BO 0383

TIMTEC-BB SBB010303

2-(4-MORPHOLINYL)ACETIC ACID

AKOS BBS-00002525

4-MORPHOLINOACETIC ACID

4-MORPHOLINACETIC ACID HCL

Morpholin-4-yl-acetic acid hydrochloride ,98%

2-Morpholinoacetic acid hydrochloride

4-Morpholineaceticacid, hydrochloride

EOS-62303

N-(carboxymethyl)morpholine hydrochloride

4-morpholinic acid hydrochloride

Morpholinoacetic Acid Hydrochloride &gt

4-Morpholineaceticacidhydrochloride,95%

4-Morpholineaceticacid, hydrochloride (1:1)

4-morpholine acetate hydrochloride

89531-58-8

Morpholineacetic acid