N,O-BIS(TRIMETHYLSILYL)HYDROXYLAMINE

ChemicalBook > CAS DataBase List > N,O-BIS(TRIMETHYLSILYL)HYDROXYLAMINE

N,O-BIS(TRIMETHYLSILYL)HYDROXYLAMINE

Product Name: N,O-BIS(TRIMETHYLSILYL)HYDROXYLAMINE
CAS No.: 22737-37-7
Chemical Name: N,O-BIS(TRIMETHYLSILYL)HYDROXYLAMINE
Synonyms: AKOS MSC-0143;Bis(trimethylsilyl)hydroxylamine;N,O-BIS(TRIMETHYLSILYL)HYDROXYLAMINE;N,0-Bis(trimethylsilyl)hydroxylamine;O,N-Bis(trimethylsilyl)hydroxylamine;N,O-Bis-(trimethylsilyl)-hydroxylamin;(Trimethylsiloxy)(trimethylsilyl)amine;N,O-Bis(trimethylsilyl)hydroxylamine >N,O-BIS(TRIMETHYLSILYL)HYDROXYLAMINE, 97 %;[dimethyl-(trimethylsilyloxyamino)silyl]methane
CBNumber: CB0779294
Molecular Formula: C6H19NOSi2
Formula Weight: 177.39
MOL File: 22737-37-7.mol

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N,O-BIS(TRIMETHYLSILYL)HYDROXYLAMINE Property

Boiling point:: 78-80 °C100 mm Hg(lit.)
Density: 0.83 g/mL at 25 °C(lit.)
refractive index: n20/D 1.411(lit.)
Flash point:: 84 °F
storage temp.: 2-8°C
solubility: sol THF, ether, pentane, CH2Cl2.
form: clear liquid
pka: 5.94±0.70(Predicted)
color: Colorless to Almost colorless
Specific Gravity: 0.83
Hydrolytic Sensitivity: 7: reacts slowly with moisture/water
BRN: 1920452
CAS DataBase Reference: 22737-37-7(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,C
Risk Statements: 10-36/37/38-34
Safety Statements: 26-36-45-36/37/39
RIDADR: UN 1993 3/PG 3
WGK Germany: 3
F: 10-21
TSCA: No
HazardClass: 3.2
PackingGroup: III
HS Code: 29319019

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H226Flammable liquid and vapour

H314Causes severe skin burns and eye damage

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 235105
Product name: N,O-Bis(trimethylsilyl)hydroxylamine
Purity: 97%
Packaging: 1g
Price: $62
Updated: 2023/01/07

Sigma-Aldrich

Product number: 235105
Product name: N,O-Bis(trimethylsilyl)hydroxylamine
Purity: 97%
Packaging: 10g
Price: $310
Updated: 2022/05/15

TCI Chemical

Product number: B1825
Product name: N,O-Bis(trimethylsilyl)hydroxylamine
Purity: >95.0%(GC)
Packaging: 5g
Price: $500
Updated: 2024/03/01

TRC

Product number: B535355
Product name: N,O-bis(Trimethylsilyl)hydroxylamine
Packaging: 100mg
Price: $60
Updated: 2021/12/16

TRC

Product number: B535355
Product name: N,O-bis(Trimethylsilyl)hydroxylamine
Packaging: 500mg
Price: $110
Updated: 2021/12/16

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N,O-BIS(TRIMETHYLSILYL)HYDROXYLAMINE Chemical Properties,Usage,Production

Chemical Properties

Clear colorless liquid

Physical properties

bp 137–139°C, 78–80°C/100 mmHg; d 0.830 g cm?3; flash point 28°C.

Uses

N,O-Bis(trimethylsilyl)hydroxylamine has been used as reagent for the preparation of N-(dialkyl phosphinoyl)hydroxylamines and migration of simple alkyl groups in rearrangement of their O-p-nitrobenzenesulfonates.

Uses

N,O-Bis(trimethylsilyl)hydroxylamine is a protected, lipophilic form of hydroxylamine. It reacts with a variety of electrophiles predominantly by attack on the nitrogen nucleophilic center. Reaction with acid chlorides (1 equiv) in the presence of triethylamine gives N,O-bis(trimethylsilyl)- hydroxamic acids by N-acylation.A related reagent, tris(trimethylsilyl) hydroxylamine, gives the same product in high yields, also by N-acylation.Hydrolysis gives the free hydroxamic acids, whereas thermal fragmentation affords isocyanates (eq 1).

Preparation

N,O-Bis(trimethylsilyl)hydroxylamine can be prepared in 69% yield by treating dry hydroxylamine with equiv chlorotrimethylsilane and equiv triethylamine.A safer preparation, which avoids the use of the explosive solid, hydroxylamine, uses the reaction of hydroxylamine hydrochloride with excess hexamethyldisilazane (71–75% yield).Alternatively, neutralization of hydroxylamine hydrochloride with ethylenediamine followed by addition of chlorotrimethylsilane can be used.

General Description

N,O-Bis(trimethylsilyl)hydroxylamine on reaction with 9-chloro-9-borafluorene yields 10-trimethylsilyloxy-9-aza-10-boraphenanthrene. It reacts with free phenolic steroids during the analysis of conjugated estrogen tablets and injectable formulations by GLC.

N,O-BIS(TRIMETHYLSILYL)HYDROXYLAMINE Preparation Products And Raw materials

Raw materials

Preparation Products

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N,O-BIS(TRIMETHYLSILYL)HYDROXYLAMINE Suppliers

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View Lastest Price from N,O-BIS(TRIMETHYLSILYL)HYDROXYLAMINE manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: N,O-BIS(TRIMETHYLSILYL)HYDROXYLAMINE 22737-37-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

Career Henan Chemical Co

Product: N,O-BIS(TRIMETHYLSILYL)HYDROXYLAMINE 22737-37-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95-99%
Supply Ability: 1ton
Release date: 2019-12-30

22737-37-7, N,O-BIS(TRIMETHYLSILYL)HYDROXYLAMINERelated Search:

L-Canavanine sulfate N-(Methylsulfonyl)-N,O-bis(trimethylsilyl)hydroxylamine N-METHYL-N,O-BIS(TRIMETHYLSILYL)HYDROXYLAMINE O-(TRIMETHYLSILYL)HYDROXYLAMINE N,N,O-TRIS(TRIMETHYLSILYL)HYDROXYLAMINE N,O-BIS(TRIMETHYLSILYL)HYDROXYLAMINE

2,2,5,5-Tetramethyl-3-oxa-4-aza-2,5-disilahexane

N,O-Bis-(trimethylsilyl)-hydroxylamin

Silanamine, 1,1,1-trimethyl-N-[(trimethylsilyl)oxy]-

1,1,1-trimethyl-N-[(trimethylsilyl)oxy]silylamine

N,O-BIS(TRIMETHYLSILYL)HYDROXYLAMINE, 97 %

N,0-Bis(trimethylsilyl)hydroxylamine

Bis(trimethylsilyl)hydroxylamine

(Trimethylsiloxy)(trimethylsilyl)amine

O,N-Bis(trimethylsilyl)hydroxylamine

α,α,α-Trimethyl-N-[(trimethylsilyl)oxy]silanamine

N,O-BIS(TRIMETHYLSILYL)HYDROXYLAMINE

<i>N</i>,<i>O</i>-Bis(trimethylsilyl)hydroxylamine

AKOS MSC-0143

[dimethyl-(trimethylsilyloxyamino)silyl]methane

N,O-Bis(trimethylsilyl)hydroxylamine &gt

22737-37-7

C6H19NOSi2

CH33SiONHSiCH33

Organic Building Blocks

Nitrogen Compounds

Si (Classes of Silicon Compounds)

Hydroxylamines (O-Substituted)

Hydroxylamines

Si-N Compounds

Hydroxylamines (N-Substituted)

Trimethylsilylazide, etc.

Building Blocks

Chemical Synthesis

Nitrogen Compounds

Organic Building Blocks

Hydroxylamines

Hydroxylamines (N-Substituted)

Hydroxylamines (O-Substituted)

Si (Classes of Silicon Compounds)

Si-N Compounds

Trimethylsilylazide, etc.

Nitrogen Compounds

Organic Building Blocks