N,O-BIS(TRIMETHYLSILYL)HYDROXYLAMINE
- Product Name
- N,O-BIS(TRIMETHYLSILYL)HYDROXYLAMINE
- CAS No.
- 22737-37-7
- Chemical Name
- N,O-BIS(TRIMETHYLSILYL)HYDROXYLAMINE
- Synonyms
- AKOS MSC-0143;Bis(trimethylsilyl)hydroxylamine;N,O-BIS(TRIMETHYLSILYL)HYDROXYLAMINE;N,0-Bis(trimethylsilyl)hydroxylamine;O,N-Bis(trimethylsilyl)hydroxylamine;N,O-Bis-(trimethylsilyl)-hydroxylamin;(Trimethylsiloxy)(trimethylsilyl)amine;N,O-Bis(trimethylsilyl)hydroxylamine >N,O-BIS(TRIMETHYLSILYL)HYDROXYLAMINE, 97 %;[dimethyl-(trimethylsilyloxyamino)silyl]methane
- CBNumber
- CB0779294
- Molecular Formula
- C6H19NOSi2
- Formula Weight
- 177.39
- MOL File
- 22737-37-7.mol
N,O-BIS(TRIMETHYLSILYL)HYDROXYLAMINE Property
- Boiling point:
- 78-80 °C100 mm Hg(lit.)
- Density
- 0.83 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.411(lit.)
- Flash point:
- 84 °F
- storage temp.
- 2-8°C
- solubility
- sol THF, ether, pentane, CH2Cl2.
- form
- clear liquid
- pka
- 5.94±0.70(Predicted)
- color
- Colorless to Almost colorless
- Specific Gravity
- 0.83
- Hydrolytic Sensitivity
- 7: reacts slowly with moisture/water
- BRN
- 1920452
- CAS DataBase Reference
- 22737-37-7(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,C
- Risk Statements
- 10-36/37/38-34
- Safety Statements
- 26-36-45-36/37/39
- RIDADR
- UN 1993 3/PG 3
- WGK Germany
- 3
- F
- 10-21
- TSCA
- No
- HazardClass
- 3.2
- PackingGroup
- III
- HS Code
- 29319019
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H226Flammable liquid and vapour
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 235105
- Product name
- N,O-Bis(trimethylsilyl)hydroxylamine
- Purity
- 97%
- Packaging
- 1g
- Price
- $62
- Updated
- 2023/01/07
- Product number
- 235105
- Product name
- N,O-Bis(trimethylsilyl)hydroxylamine
- Purity
- 97%
- Packaging
- 10g
- Price
- $310
- Updated
- 2022/05/15
- Product number
- B1825
- Product name
- N,O-Bis(trimethylsilyl)hydroxylamine
- Purity
- >95.0%(GC)
- Packaging
- 5g
- Price
- $500
- Updated
- 2024/03/01
- Product number
- B535355
- Product name
- N,O-bis(Trimethylsilyl)hydroxylamine
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- B535355
- Product name
- N,O-bis(Trimethylsilyl)hydroxylamine
- Packaging
- 500mg
- Price
- $110
- Updated
- 2021/12/16
N,O-BIS(TRIMETHYLSILYL)HYDROXYLAMINE Chemical Properties,Usage,Production
Chemical Properties
Clear colorless liquid
Physical properties
bp 137–139°C, 78–80°C/100 mmHg; d 0.830 g cm?3; flash point 28°C.
Uses
N,O-Bis(trimethylsilyl)hydroxylamine has been used as reagent for the preparation of N-(dialkyl phosphinoyl)hydroxylamines and migration of simple alkyl groups in rearrangement of their O-p-nitrobenzenesulfonates.
Uses
N,O-Bis(trimethylsilyl)hydroxylamine
is a protected, lipophilic form of hydroxylamine. It reacts
with a variety of electrophiles predominantly by attack on the nitrogen
nucleophilic center. Reaction with acid chlorides (1 equiv)
in the presence of triethylamine gives N,O-bis(trimethylsilyl)-
hydroxamic acids by N-acylation.A related reagent, tris(trimethylsilyl)
hydroxylamine, gives the same product in high yields,
also by N-acylation.Hydrolysis gives the free hydroxamic
acids, whereas thermal fragmentation affords isocyanates (eq 1).
Preparation
N,O-Bis(trimethylsilyl)hydroxylamine can be prepared in 69% yield by treating dry hydroxylamine with equiv chlorotrimethylsilane and equiv triethylamine.A safer preparation, which avoids the use of the explosive solid, hydroxylamine, uses the reaction of hydroxylamine hydrochloride with excess hexamethyldisilazane (71–75% yield).Alternatively, neutralization of hydroxylamine hydrochloride with ethylenediamine followed by addition of chlorotrimethylsilane can be used.
General Description
N,O-Bis(trimethylsilyl)hydroxylamine on reaction with 9-chloro-9-borafluorene yields 10-trimethylsilyloxy-9-aza-10-boraphenanthrene. It reacts with free phenolic steroids during the analysis of conjugated estrogen tablets and injectable formulations by GLC.
N,O-BIS(TRIMETHYLSILYL)HYDROXYLAMINE Preparation Products And Raw materials
Raw materials
Preparation Products
N,O-BIS(TRIMETHYLSILYL)HYDROXYLAMINE Suppliers
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- 03-36680489
- Fax
- 03-3668-0520
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- Japan
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View Lastest Price from N,O-BIS(TRIMETHYLSILYL)HYDROXYLAMINE manufacturers
- Product
- N,O-BIS(TRIMETHYLSILYL)HYDROXYLAMINE 22737-37-7
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11
- Product
- N,O-BIS(TRIMETHYLSILYL)HYDROXYLAMINE 22737-37-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95-99%
- Supply Ability
- 1ton
- Release date
- 2019-12-30