Thalidomide-O-PEG4-azide

Product Name: Thalidomide-O-PEG4-azide
CAS No.: 2380318-57-8
Chemical Name: Thalidomide-O-PEG4-azide
Synonyms: Thalidomide-O-PEG4-N3;Thalidomide-O-PEG4-azide;4-((14-azido-3,6,9,12-tetraoxatetradecyl)oxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;1H-Isoindole-1,3(2H)-dione, 4-[(14-azido-3,6,9,12-tetraoxatetradec-1-yl)oxy]-2-(2,6-dioxo-3-piperidinyl)-
CBNumber: CB08054841
Molecular Formula: C23H29N5O9
Formula Weight: 519.51
MOL File: 2380318-57-8.mol

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Thalidomide-O-PEG4-azide Property

storage temp.: -20°C, sealed storage, away from moisture
solubility: Soluble in Water, DMF, DCM, DMSO
form: Oil
color: Colorless to light yellow

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

BroadPharm

Product number: BP-24418
Product name: Thalidomide-O-PEG4-Azide
Purity: 98%
Packaging: 100mg
Price: $540
Updated: 2021/12/16

BroadPharm

Product number: BP-24418
Product name: Thalidomide-O-PEG4-Azide
Purity: 98%
Packaging: 500mg
Price: $1930
Updated: 2021/12/16

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Thalidomide-O-PEG4-azide Chemical Properties,Usage,Production

Description

Thalidomide-O-PEG4-Azide is a PROTAC linker that is reactive with alkyne or DBCO, BCN attached molecule via click chemistry

Uses

Thalidomide-O-PEG4-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. Thalidomide-O-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC 50

Cereblon

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Thalidomide-O-PEG4-azide Preparation Products And Raw materials

Raw materials

Preparation Products

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Thalidomide-O-PEG4-azide Suppliers

China 24 United States 2 Global 26

Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd

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View Lastest Price from Thalidomide-O-PEG4-azide manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: Thalidomide-O-PEG4-azide 2380318-57-8
Price: US $0.00/mg
Min. Order: 100mg
Purity: >96.00%
Supply Ability: 100mg
Release date: 2024-04-01

2380318-57-8, Thalidomide-O-PEG4-azideRelated Search:

Thalidomide-4-O-C8-NH2 Thalidomide-O-PEG4-Boc 2-(2,6-Dioxo-3-piperidinyl)-4-[2-[2-(2-propyn-1-yloxy)oxy]ethoxy]-1H-isoindole-1,3(2H)dione Octanoic acid, 8-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]- Thalidomide-O-PEG4-amine Thalidomide-O-PEG4-NHS ester 4-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione Thalidomide-O-PEG3-amine HCl Acetamide, N-[2-[3-[3-(2-aminoethoxy)propoxy]propoxy]ethyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-

Thalidomide-O-PEG4-azide

4-((14-azido-3,6,9,12-tetraoxatetradecyl)oxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

Thalidomide-O-PEG4-N3

1H-Isoindole-1,3(2H)-dione, 4-[(14-azido-3,6,9,12-tetraoxatetradec-1-yl)oxy]-2-(2,6-dioxo-3-piperidinyl)-

2380318-57-8

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