ChemicalBook > CAS DataBase List > Blosozumab
Blosozumab
- Product Name
- Blosozumab
- CAS No.
- 1132758-87-2
- Chemical Name
- Blosozumab
- Synonyms
- Blosozumab;Blosozumab (anti-SOST);Research Grade Blosozumab;Research Grade Blosozumab(DHJ48702)
- CBNumber
- CB08080837
- Formula Weight
- 0
- MOL File
- Mol file
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Blosozumab Property
- form
- Liquid
- color
- Colorless to light yellow
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N-Bromosuccinimide Price
DC Chemicals
- Product number
- A512
- Product name
- Blosozumab Biosimilar(Anti-SOST / Sclerostin Reference Antibody)
- Purity
- >98%
- Packaging
- 1mg
- Price
- $450
- Updated
- 2026/05/24
DC Chemicals
- Product number
- A512
- Product name
- Blosozumab Biosimilar(Anti-SOST / Sclerostin Reference Antibody)
- Purity
- >98%
- Packaging
- 5mg
- Price
- $750
- Updated
- 2026/05/24
DC Chemicals
- Product number
- A512
- Product name
- Blosozumab Biosimilar(Anti-SOST / Sclerostin Reference Antibody)
- Purity
- >98%
- Packaging
- 10mg
- Price
- $1100
- Updated
- 2026/05/24
DC Chemicals
- Product number
- A512
- Product name
- Blosozumab Biosimilar(Anti-SOST / Sclerostin Reference Antibody)
- Purity
- >98%
- Packaging
- 20mg
- Price
- $1300
- Updated
- 2026/05/24
DC Chemicals
- Product number
- A512
- Product name
- Blosozumab Biosimilar(Anti-SOST / Sclerostin Reference Antibody)
- Purity
- >98%
- Packaging
- 50mg
- Price
- $1600
- Updated
- 2026/05/24
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Blosozumab Chemical Properties,Usage,Production
Uses
Blosozumab (LY2541546) is an anti-Human sclerostin (SOST) antibody inhibitor. Blosozumab stimulates bone formation and reduces bone resorption. Blosozumab can be used in the research of Osteoporosis[1][2].
in vivo
Blosozumab (1-100 mg/kg, i.v.) shows effects of hyperostosis in rats[1].
| Animal Model: | Sprague-Dawley rats [2] |
| Dosage: | 1, 10, and 100 mg/kg |
| Administration: | Intravenous injection (i.v.), once every 3 days (5-week study) or once weekly (6-month study) |
| Result: | Observed the bone anabolic effects. Showed significant bleeding and morbidity at 100 mg/kg. Decreases in the numbers of platelets. Increased number of bone marrow megakaryocytes at 100 mg/kg. |
References
[1] Robert R Recker, et al. A randomized, double-blind phase 2 clinical trial of blosozumab, a sclerostin antibody, in postmenopausal women with low bone mineral density. J Bone Miner Res. 2015 Feb;30(2):216-24. DOI:10.1002/jbmr.2351
[2] Daniel G Rudmann, et al. Rat-specific decreases in platelet count caused by a humanized monoclonal antibody against sclerostin. Toxicol Sci. 2012 Feb;125(2):586-94. DOI:10.1093/toxsci/kfr318
Blosozumab Preparation Products And Raw materials
Raw materials
Preparation Products
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Blosozumab Suppliers
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