Bimagrumab
- Product Name
- Bimagrumab
- CAS No.
- 1356922-05-8
- Chemical Name
- Bimagrumab
- Synonyms
- Bimagrumab;Bimagrumab (anti-ACVR2B);Research Grade Bimagrumab;Research Grade Bimagrumab(DHD72801)
- CBNumber
- CB08080877
- Formula Weight
- 0
- MOL File
- Mol file
Bimagrumab Property
- form
- Liquid
- color
- Colorless to light yellow
N-Bromosuccinimide Price
- Product number
- orb1290220
- Product name
- Bimagrumab
- Purity
- >95%
- Packaging
- 100μg
- Price
- $200
- Updated
- 2026/05/06
- Product number
- orb1290220
- Product name
- Bimagrumab
- Purity
- >95%
- Packaging
- 1mg
- Price
- $820
- Updated
- 2026/05/06
- Product number
- HY-P99355
- Product name
- Bimagrumab
- Purity
- 99.31%
- Packaging
- 1mg
- Price
- $380
- Updated
- 2026/05/26
- Product number
- HY-P99355
- Product name
- Bimagrumab
- Purity
- 99.31%
- Packaging
- 5mg
- Price
- $950
- Updated
- 2026/05/26
- Product number
- HY-P99355
- Product name
- Bimagrumab
- Purity
- 99.31%
- Packaging
- 10mg
- Price
- $1520
- Updated
- 2026/05/26
Bimagrumab Chemical Properties,Usage,Production
Uses
Bimagrumab (Anti-ACVR2B Reference Antibody) is a human monoclonal antibody that blocks activin type II receptor (ActRII), with KDs of 1.7 pM and 434 pM for human ActRIIB and ActRIIA, respectively. Bimagrumab can be used for the research of pathological muscle loss and weakness[1][2].
in vivo
BYM338 (6-20 mg/kg; s.c. once weekly for 4 weeks) promotes an increase in body weight and skeletal muscle hypertrophy of all examined muscles, slow, fast, and mixed of young SCID mice[2].
BYM338 (5-20 mg/kg; s.c. once weekly for 14 d) prevents Glucocorticoid-induced muscle wasting in mice[2].
IC 50
ACVR2B: 1.7 pM (Kd); ACVR2A: 434 pM (Kd)
References
[1] Heymsfield SB, et, al. Effect of Bimagrumab vs Placebo on Body Fat Mass Among Adults With Type 2 Diabetes and Obesity: A Phase 2 Randomized Clinical Trial. JAMA Netw Open. 2021 Jan 4;4(1):e2033457. DOI:10.1001/jamanetworkopen.2020.33457
[2] Lach-Trifilieff E, et, al. An antibody blocking activin type II receptors induces strong skeletal muscle hypertrophy and protects from atrophy. Mol Cell Biol. 2014 Feb;34(4):606-18. DOI:10.1128/MCB.01307-13
Bimagrumab Preparation Products And Raw materials
Raw materials
Preparation Products
Bimagrumab Suppliers
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- 18007167883 18007167883
- Service@mabnus.com
- Country
- China
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- 906
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- China
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- 027-65279366 18108604356
- products@biolabreagent.com
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- China
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- 13720134139 086-15871494362 13720134139
- orders@jknbiochem.com
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- China
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- 021-65675885 18964387627
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