NU6102 Property

Melting point:

152-154℃ (water )

storage temp. 

Store at -20°C

solubility 

DMSO:1.0(Max Conc. mg/mL);2.5(Max Conc. mM)

form 

White to off-white solid.

color 

White to off-white

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H341Suspected of causing genetic defects

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

NU6102 Chemical Properties,Usage,Production

Uses

Cyclin-dependent kinases (CDKs) play a key role in regulating cell division by phosphorylating distinct substrates in different phases of the cell cycle. Cell cycle deregulation in many cancers often results from altered CDK activity. Thus, CDKs are potential pharmacological targets for anticancer agents. NU 6102 is a potent inhibitor of Cdk1 and Cdk2 with Ki values of 9 and 6 nM and IC50 values of 9.5 and 5.4 nM, respectively. NU 6102 inhibits Cdk4 activity with an IC50 value of 1.6 μM, suggesting it is most selective for Cdk2. Time-lapse videomicroscopy reveals that 20 μM NU 6102 delays cell entry into mitosis where most cells appear to eventually complete mitotic division but cannot correctly undergo cytokinesis, and hence become binucleated with an abnormal number of centrosomes. In SKUT-1B cancer cells a 24 h exposure to NU 6102 induced G2 arrest, inhibition of target protein phosphorylation, and cytotoxicity with an LC50 value of 2.6 μM.

Uses

NU6102 is a known potent inhibitor of CDK1, CDK2 and CDK7. Cyclin-dependent kinases play a key role in the regulation of cell division which is controlled by the phosphorylation of distinct substrates in different phases of the cell cycle. In any circumstance where the cell cycle is deregulated, cyclin-dependent kinases activities are altered. Since NU6102 is known to exert inhibitory activities against CDKs, it has potential to act as a control in the cell cycle, especially in various cancers. NU6102 is known to be an anticancer agent use to repress the expression of breast cancer cells.

storage

+4°C