(S)-TETRAHYDROFURAN-3-AMINE HYDROCHLORIDE
- Product Name
- (S)-TETRAHYDROFURAN-3-AMINE HYDROCHLORIDE
- CAS No.
- 204512-95-8
- Chemical Name
- (S)-TETRAHYDROFURAN-3-AMINE HYDROCHLORIDE
- Synonyms
- (S)-Tetrahydrofuran-;(3S)-tetrahydrofuran-3-amine;(S)-3-AMinotetrahydrofuran, HCl;(3S)-3-oxolanamine hydrochloride;(3S)-Tetrahydro-3-furanaMine HCl;(3S)-oxolan-3-aMine hydrochloride;[(3S)-Oxolan-3-yl]amine hydrochloride;(S)4-Aminotetrahydrofuran hydrochloride;(S)-3-aminotetrahydrofuran hydrochloride;(S)-Tetrahydro-3-furylamine hydrochloride
- CBNumber
- CB0813374
- Molecular Formula
- C4H10ClNO
- Formula Weight
- 123.58
- MOL File
- 204512-95-8.mol
(S)-TETRAHYDROFURAN-3-AMINE HYDROCHLORIDE Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- Solid
- Appearance
- White to off-white Crystal
- optical activity
- Consistent with structure
- InChI
- InChI=1/C4H9NO.ClH/c5-4-1-2-6-3-4;/h4H,1-3,5H2;1H/t4-;/s3
- InChIKey
- MHOVLDXJDIEEMJ-WCCKRBBISA-N
- SMILES
- N[C@@H]1COCC1.Cl |&1:1,r|
- CAS DataBase Reference
- 204512-95-8
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-37/38-41
- Safety Statements
- 26-39
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- A630755
- Product name
- (S)-3-AminotetrahydrofuranHydrochloride
- Packaging
- 5g
- Price
- $565
- Updated
- 2021/12/16
- Product number
- AS18386-B
- Product name
- (S)-3-Aminotetrahydrofuran HCl
- Purity
- 96% ee
- Packaging
- 1g
- Price
- $32
- Updated
- 2021/12/16
- Product number
- 073909
- Product name
- (S)-3-Aminotetrahydrofuran hydrochloride
- Purity
- 95+%
- Packaging
- 1g
- Price
- $45
- Updated
- 2021/12/16
- Product number
- BP-11345
- Product name
- (S)-tetrahydrofuran-3-amine
- Purity
- 96%
- Packaging
- 250mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- AS18386-B
- Product name
- (S)-3-Aminotetrahydrofuran HCl
- Purity
- 96% ee
- Packaging
- 5G
- Price
- $132
- Updated
- 2021/12/16
(S)-TETRAHYDROFURAN-3-AMINE HYDROCHLORIDE Chemical Properties,Usage,Production
Uses
(S)-3-Aminotetrahydrofuran Hydrochloride is an intermediate used to prepare 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) Inhibitors.
Synthesis
152495-79-9
204512-95-8
(S)-3-Benzoylamino tetrahydrofuran (20.0 g, 0.105 mol) was dissolved in ethanol (40 mL), followed by addition of an aqueous sodium hydroxide solution (25 g sodium hydroxide dissolved in 120 mL of water). The reaction mixture was heated to reflux for 9-10 h. The reaction was monitored by TLC until complete disappearance of the starting material. After completion of the reaction, the mixture was cooled to room temperature and acidified with dilute hydrochloric acid. The precipitated benzoic acid was removed by filtration and the aqueous phase was washed with dichloromethane and concentrated to give a crude product containing the salt. Isopropanol was added to the crude product and stirred at room temperature for 1 hour. The salt was removed by filtration and the filtrate was concentrated to dryness to give a paste. The paste was co-stirred with isopropanol to promote crystallization and subsequently filtered, washed with cold isopropanol and dried under vacuum. Yield: 11 g (85% of theoretical yield); Melting point: 165-170 °C; [α]27D = -10.2 (c 1 , methanol); 1H NMR (300 MHz, CDCl3) δ (ppm): 3.80-4.11 (m, 5H), 2.37-2.5 (m, 1H), 2.01-2.09 (m, 1H); 13C NMR ( 300 MHz, CDCl3) δ (ppm): 70.49, 66.82, 51.21, 30.01; Elemental analysis (C4H10ClNO, FW 123.5813) Calculated values: C, 38.88; H, 8.16; N, 11.33. Measured values: C, 38.97; H, 7.86; N, 11.39. By transforming the product converted to its benzoyl derivative and analyzed by chiral HPLC using a Chiralpak AD-H column to determine the enantiomeric excess (Figure 2).
References
[1] Tetrahedron Asymmetry, 2013, vol. 24, # 11, p. 663 - 668
[2] Patent: US2008/255377, 2008, A1. Location in patent: Page/Page column 3
(S)-TETRAHYDROFURAN-3-AMINE HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
(S)-TETRAHYDROFURAN-3-AMINE HYDROCHLORIDE Suppliers
- Tel
- --
- Fax
- --
- info@manchesterorganics.com
- Country
- United Kingdom
- ProdList
- 6834
- Advantage
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View Lastest Price from (S)-TETRAHYDROFURAN-3-AMINE HYDROCHLORIDE manufacturers
- Product
- (3S)-oxolan-3-amine,hydrochloride 204512-95-8
- Price
- US $9.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 10KG
- Release date
- 2021-09-24
- Product
- (S)-tetrahydrofuran-3-amine hydrochloride 204512-95-8
- Price
- US $9.00/Kg/Bag
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10kg
- Release date
- 2021-09-24
- Product
- (S)-tetrahydrofuran-3-amine hydrochloride 204512-95-8
- Price
- US $9.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2021-09-24