ChemicalBook > CAS DataBase List > 2-AMINO-5-BROMO-6-METHYLPYRAZINE

2-AMINO-5-BROMO-6-METHYLPYRAZINE

Product Name: 2-AMINO-5-BROMO-6-METHYLPYRAZINE
CAS No.: 74290-69-0
Chemical Name: 2-AMINO-5-BROMO-6-METHYLPYRAZINE
Synonyms: 5-Bromo-6-methyl-2-pyrazinamine;5-bromo-6-methylpyrazin-2-amine;2-AMINO-5-BROMO-6-METHYLPYRAZINE;2-Pyrazinamine, 5-bromo-6-methyl-;5-BROMO-6-METHYLPYRAZIN-2-YLAMINE;2-AMINO-5-BROMO-6-METHYLPYRAZINE ISO 9001：2015 REACH
CBNumber: CB0839352
Molecular Formula: C5H6BrN3
Formula Weight: 188.03
MOL File: 74290-69-0.mol

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2-AMINO-5-BROMO-6-METHYLPYRAZINE Property

Boiling point:: 273.8±35.0 °C(Predicted)
Density: 1.699±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 1.96±0.10(Predicted)
Appearance: White to off-white Solid

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: A594600
Product name: 2-Amino-5-bromo-6-methylpyrazine
Packaging: 25mg
Price: $45
Updated: 2021/12/16

AK Scientific

Product number: W8204
Product name: 2-Amino-5-bromo-6-methylpyrazine
Packaging: 250mg
Price: $146
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H30-9-2R
Product name: 2-Amino-5-bromo-6-methylpyrazine
Purity: 95%
Packaging: 250mg
Price: $296
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB143944
Product name: 5-Bromo-6-methylpyrazin-2-amine
Packaging: 500mg
Price: $300
Updated: 2021/12/16

Matrix Scientific

Product number: 076260
Product name: 2-Amino-5-bromo-6-methylpyrazine
Purity: 95+%
Packaging: 250mg
Price: $416
Updated: 2021/12/16

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2-AMINO-5-BROMO-6-METHYLPYRAZINE Chemical Properties,Usage,Production

Synthesis

5521-56-2

74290-69-0

General procedure for the synthesis of 2-amino-5-bromo-6-methylpyrazine from 2-amino-6-methylpyrazine: 6-amino-2-methylpyrazine (100 mg, 1.0 eq.) was dissolved in a solvent mixture of DMSO (4.6 mL) and water (0.2 mL) under an inert atmosphere and cooled in an ice bath. To this solution was added N-bromosuccinimide (NBS, 179 mg, 1.1 eq.) in three portions. The reaction mixture was light yellow in color and stirred for 15 minutes, then the ice bath was removed and stirring was continued for 5 hours at room temperature. After completion of the reaction, the reaction was quenched with saturated NaHCO3 solution (25 mL) and extracted with ethyl acetate (EtOAc, 30 mL). The organic layer was washed with brine, dried over anhydrous Na2SO4 and concentrated under reduced pressure. Purification by fast column chromatography afforded the target compound 2-amino-5-bromo-6-methylpyrazine (Compound 10) as a light yellow solid in 36% yield.1H-NMR (400 MHz, DMSO-d6): δ 2.34 (s, 3H, CH3), 6.52 (s, 2H, NH2), 7.49 (s, 1H, Ar-H). Mass spectrum (ESI): m/z 188.2 ([M+H]+, 79Br).

References

[1] Patent: EP2666775, 2013, A1. Location in patent: Paragraph 02222
[2] Patent: WO2013/174822, 2013, A1. Location in patent: Page/Page column 86

2-AMINO-5-BROMO-6-METHYLPYRAZINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-AMINO-5-BROMO-6-METHYLPYRAZINE Suppliers

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View Lastest Price from 2-AMINO-5-BROMO-6-METHYLPYRAZINE manufacturers

Dideu Industries Group Limited

Product: 2-AMINO-5-BROMO-6-METHYLPYRAZINE 74290-69-0
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-12-07

Career Henan Chemical Co

Product: 2-AMINO-5-BROMO-6-METHYLPYRAZINE 74290-69-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 100kg
Release date: 2020-01-14

74290-69-0, 2-AMINO-5-BROMO-6-METHYLPYRAZINERelated Search:

2-Amino-4-methyl-5-bromopyrimidine 5-BROMO-N-(1-ETHYLPROPYL)-3-METHOXY-6-METHYLPYRAZIN-2-AMINE TERT-BUTYL 4-[5-BROMO-6-(3-CHLOROPYRIDIN-4-YL)PYRAZIN-2-YL]PIPERAZINE-1-CARBOXYLATE 2-[3-BROMO-5-(1-ETHYLPROPOXY)-6-(METHYLAMINO)PYRAZIN-2-YL]-5-(TRIFLUOROMETHOXY)PHENOL 2-AMINO-3,5-DIBROMO-6-METHYLPYRAZINE 4-[5-BROMO-6-(3-CHLORO-PYRIDIN-4-YL)-PYRAZIN-2-YLAMINO]-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 3,5-DIBROMO-6-[4-(TRIFLUOROMETHYL)PHENYL]PYRAZIN-2-AMINE 5-BROMO-N-METHYL-6-[4-FLUOROPHENYL]PYRAZIN-2-AMINE 3,5-DIBROMO-6-(4-FLUOROPHENYL)-N-METHYLPYRAZIN-2-AMINE 2-AMINO-5-BROMO-6-METHYLPYRAZINE 5-BROMO-N-(1-ETHYLPROPYL)-6-METHYLPYRAZIN-2-AMINE 5-BROMO-6-ETHYL-N-(1-ETHYLPROPYL)PYRAZIN-2-AMINE

2-AMINO-5-BROMO-6-METHYLPYRAZINE

5-BROMO-6-METHYLPYRAZIN-2-YLAMINE

5-bromo-6-methylpyrazin-2-amine

2-Pyrazinamine, 5-bromo-6-methyl-

2-AMINO-5-BROMO-6-METHYLPYRAZINE ISO 9001：2015 REACH

5-Bromo-6-methyl-2-pyrazinamine

74290-69-0