ChemicalBook > CAS DataBase List > 5-AMINO-2H-ISOQUINOLIN-1-ONE

5-AMINO-2H-ISOQUINOLIN-1-ONE

Product Name: 5-AMINO-2H-ISOQUINOLIN-1-ONE
CAS No.: 93117-08-9
Chemical Name: 5-AMINO-2H-ISOQUINOLIN-1-ONE
Synonyms: 5-AIQ;5-AIQ, 10 mM in DMSO;5-aMinoisoquinolin-1-ol;5-Aminoisoquinolin-1(2H);5-AMino-2H-isoquinolin-1-ol;5-amino-2H-isoquinoin-1-one;5-AMINO-2H-ISOQUINOLIN-1-ONE;5-aMinoisoquinolin-1(2H)-one;5-Amino-1(2H)-isoquinolinone;1(2H)-Isoquinolinone, 5-aMino-
CBNumber: CB0842750
Molecular Formula: C9H8N2O
Formula Weight: 160.17
MOL File: 93117-08-9.mol

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5-AMINO-2H-ISOQUINOLIN-1-ONE Property

Melting point:: 249-250°C
Density: 1.287
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
color: Light Beige to Light Brown

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Safety

HS Code: 2933499090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TRC

Product number: A612905
Product name: 5-Amino-2H-isoquinolin-1-one
Packaging: 250mg
Price: $130
Updated: 2021/12/16

ChemScene

Product number: CS-W006566
Product name: 5-AIQ
Purity: 99.44%
Packaging: 100mg
Price: $70
Updated: 2021/12/16

ChemScene

Product number: CS-W006566
Product name: 5-AIQ
Purity: 99.44%
Packaging: 250mg
Price: $111
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: A12854
Product name: 5-Amino-2H-isoquinolin-1-ol
Purity: 90%
Packaging: 1g
Price: $150
Updated: 2021/12/16

ChemScene

Product number: CS-W006566
Product name: 5-AIQ
Purity: 99.44%
Packaging: 1g
Price: $275
Updated: 2021/12/16

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5-AMINO-2H-ISOQUINOLIN-1-ONE Chemical Properties,Usage,Production

Uses

5-Amino-2H-isoquinolin-1-one is a reactant used in the synthesis of glucoorticoid receptor agonists as well as PARP inhibitors used in the treatment of tumors.

Definition

ChEBI: 5-amino-2H-isoquinolin-1-one is a member of isoquinolines.

Synthesis

82827-08-5

93117-08-9

General procedure for the synthesis of 5-amino-1(2H)-isoquinolinone from 5-nitro-1(2H)-isoquinolinone: To a reaction flask was added 378.3 mg (1.51 mmol) of 5-nitroisoquinolin-1(2H)-one, 376.5 mg of ammonium chloride, 2.6 mL of water and a solvent mixture of 14 mL of ethanol and 5.4 mL of tetrahydrofuran. 1.23 g of zinc powder was added in batches at 30 to 35 °C and the reaction was stirred continuously for 2 hours. Upon completion of the reaction, the reaction mixture was filtered by pumping through a glass fiber filter and the filter cake was washed with ethyl acetate. The filtrates were combined and washed sequentially with water and saturated sodium chloride solution, and then the organic phase was treated as usual. Finally, the desiccant was removed by filtration and the solvent was removed by concentration under reduced pressure to afford 196.5 mg (88.1% yield) of the target product 5-amino-1(2H)-isoquinolinone. The product was characterized by 1H-NMR (300 MHz, DMSO-d6): δ=5.6 (2H), 6.68 (1H), 6.87-7.45 (1H), 7.00 (1H), 7.17 (1H), 7.39 (1H), 11.7 (1H).

in vivo

5-AIQ (150 and 250 mg/kg; p.o.; once) possess no significantly genotoxic in vivo system by micronucleus test^[1]. 5-AIQ (3 mg/kg; p.o.; 5 min prior to onset of liver ischemia) reduces the tissue injury associated with ischemia-reperfusion of the liver^[2].

Animal Model:	Male mice^[1]
Dosage:	150 and 250 mg/kg
Administration:	Oral administration; 150 and 250 mg/kg; once
Result:	Showed no increase of micronucleated polychromatic erythrocytes (MNPCE) in both 24 h and 48 h after both 125 and 250 mg/kg duration exposure as compared to the corresponding control.

Animal Model:	Anesthetised male Wistar rats with liver ischemia (for 30 minutes) and reperfusion (for 2 hours) ^[2]
Dosage:	3 mg/kg
Administration:	Intravenous injection; 3 mg/kg; 5 min prior to onset of liver ischemia
Result:	Reduced PARP activation and showed less staining for ICAM-1.

References

[1] Patent: WO2005/35518, 2005, A1. Location in patent: Page/Page column 24
[2] Patent: WO2005/34939, 2005, A1. Location in patent: Page/Page column 56
[3] Patent: US2005/131226, 2005, A1. Location in patent: Page/Page column 8-9
[4] Patent: US2005/222154, 2005, A1. Location in patent: Page/Page column 16

5-AMINO-2H-ISOQUINOLIN-1-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

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5-AMINO-2H-ISOQUINOLIN-1-ONE Suppliers

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View Lastest Price from 5-AMINO-2H-ISOQUINOLIN-1-ONE manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 5-AMINO-2H-ISOQUINOLIN-1-ONE 93117-08-9
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1000kg
Release date: 2025-06-08

Career Henan Chemical Co

Product: 5-AMINO-2H-ISOQUINOLIN-1-ONE 93117-08-9
Price: US $2.00/KG
Min. Order: 1KG
Purity: 98%MIN
Supply Ability: ASK
Release date: 2019-12-25

93117-08-9, 5-AMINO-2H-ISOQUINOLIN-1-ONERelated Search:

Methyl 5-aMino-2-chloropyridine-3-carboxylate 5-AMINO-3-BROMO-2-METHYLPYRIDINE 3-PYRIDINAMINE, 6-CHLORO-5-IODO- Methyl 5-aMino-6-hydroxypyridine-3-carboxylate 8-BROMOQUINOLIN-5-AMINE 5-Amino-1,4-benzodioxane 5-aMino-6-chloronicotinaldehyde 5-Amino-1-chloroisoquinoline 2-BROMOPYRIMIDIN-5-AMINE 5-AMINO-2,4-DIFLUOROPHENOL 5-AMINO-PYRAZINE-2-CARBOXYLIC ACID Ethyl 5-amino-2-pyridinecarboxylate 5- amino-7-azaindole methyl 5-amino-2-chloroisonicotinate 5-AIQ HYDROCHLORIDE 5-NITRO-1(2H)-ISOQUINOLINONE 5-AMINO-2H-ISOQUINOLIN-1-ONE 2-allyl-5-nitro-1(2H)-isoquinolinone

5-AMINO-2H-ISOQUINOLIN-1-ONE

1(2H)-Isoquinolinone,5-amino-(9CI)

5-amino-2H-isoquinoin-1-one

5-aMinoisoquinolin-1-ol

5-Amino-1(2H)-isoquinolinone

5-aMinoisoquinolin-1(2H)-one

5-aMino-1,2-dihydroisoquinolin-1-one

1(2H)-Isoquinolinone, 5-aMino-

5-Aminoisoquinolin-1(2H)

5-aMinoisoquinolin-1-ol/5-aMinoisoquinolin-1(2H)-one

5-AMino-2H-isoquinolin-1-ol

5-AMINO-2H-ISOQUINOLIN-1-ONE ISO 9001：2015 REACH

5-AIQ

5 amino 1,2 dihydroisoquinolin 1 one,5amino1,2dihydroisoquinolin1one

5-amino-1 (2H) - Isoquinoline one

5-AIQ, 10 mM in DMSO

93117-08-9

ISOQUINOLINE