5-AMINO-PYRAZINE-2-CARBOXYLIC ACID
- Product Name
- 5-AMINO-PYRAZINE-2-CARBOXYLIC ACID
- CAS No.
- 40155-43-9
- Chemical Name
- 5-AMINO-PYRAZINE-2-CARBOXYLIC ACID
- Synonyms
- 5-aminopyrazine-2-carboxylic;5-Aminopyrazine-2-carboxylicaci;2-amino-5-pirazinecarboxylic acid;2-Amino-5-pyrazinecarboxylic acid;5-AMINO-2-PYRAZINECARBOXYLIC ACID;5-AMINO-PYRAZINE-2-CARBOXYLIC ACID;2-Pyrazinecarboxylic acid, 5-amino-;Pyrazinecarboxylic acid, 5-amino- (7CI,9CI);5-AMINO-PYRAZINE-2-CARBOXYLIC ACID USP/EP/BP
- CBNumber
- CB2127255
- Molecular Formula
- C5H5N3O2
- Formula Weight
- 139.11
- MOL File
- 40155-43-9.mol
5-AMINO-PYRAZINE-2-CARBOXYLIC ACID Property
- Melting point:
- 283 °C (decomp)
- Boiling point:
- 431.8±45.0 °C(Predicted)
- Density
- 1.533±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- form
- Solid
- pka
- 4.41±0.10(Predicted)
- Appearance
- Light brown to off-white Solid
- InChI
- InChI=1S/C5H5N3O2/c6-4-2-7-3(1-8-4)5(9)10/h1-2H,(H2,6,8)(H,9,10)
- InChIKey
- FMEFOOOBIHQRMK-UHFFFAOYSA-N
- SMILES
- C1(C(O)=O)=NC=C(N)N=C1
- CAS DataBase Reference
- 40155-43-9(CAS DataBase Reference)
Safety
- HazardClass
- IRRITANT
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- A616530
- Product name
- 5-Aminopyrazine-2-carboxylicAcid
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 057894
- Product name
- 5-Amino-pyrazine-2-carboxylic acid
- Purity
- 95%
- Packaging
- 500mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- 076096
- Product name
- 2-Amino-5-pyrazinecarboxylicacid
- Purity
- 95+%
- Packaging
- 1g
- Price
- $62
- Updated
- 2021/12/16
- Product number
- FA09828
- Product name
- 5-Amino-2-pyrazinecarboxylic acid
- Packaging
- 100mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- FA09828
- Product name
- 5-Amino-2-pyrazinecarboxylic acid
- Packaging
- 250mg
- Price
- $100
- Updated
- 2021/12/16
5-AMINO-PYRAZINE-2-CARBOXYLIC ACID Chemical Properties,Usage,Production
Synthesis
36070-80-1
40155-43-9
The general procedure for the synthesis of 5-aminopyrazine-2-carboxylic acid from 5-chloropyrazine-2-carboxylic acid was as follows: first, the substitution reaction was carried out by substituting 5-chloropyrazine-2-carboxylic acid (317 mg, 2 mmol) with 25% (m/m) aqueous ammonia solution (3 mL) in a 10 mL microwave pressurized vial. The reaction conditions were set to 100 °C, 30 min, 80 W power output, and under stirring. This reaction was repeated 20 times to obtain sufficient amount of starting acid. Upon completion of the reaction, the vial contents were transferred to a petri dish, heated on a water bath with intermittent stirring until a dry solid (i.e., the ammonium salt form of the product) was obtained. To obtain the free acid form, the ammonium salt was dissolved in water and adjusted dropwise to pH 4 by addition of 10% hydrochloric acid.Subsequently, the mixture was cooled at room temperature for 5 min and then placed in a refrigerator for 15 min. The free acid crystals formed were collected by diafiltration and dried overnight. Next, the dried 5-aminopyrazine-2-carboxylic acid (278 mg, 2 mmol) was mixed with 3 mL of anhydrous propanol and 2 drops of concentrated sulfuric acid and placed in a microwave pressurized vial for esterification. The esterification conditions were 100 °C, 1 h and 80 W power output. The reaction process was monitored by TLC (unfolding agent: hexane/ethyl acetate, 1:3). Finally, the ester product was purified by fast chromatography with an elution gradient of 40% to 100% ethyl acetate in hexane solution.
References
[1] Molecules, 2017, vol. 22, # 10,
5-AMINO-PYRAZINE-2-CARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-AMINO-PYRAZINE-2-CARBOXYLIC ACID manufacturers
- Product
- 5-AMINO-PYRAZINE-2-CARBOXYLIC ACID 40155-43-9
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-11
- Product
- 5-AMINO-PYRAZINE-2-CARBOXYLIC ACID 40155-43-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 150KG
- Release date
- 2019-07-01