5-Aminopyrazine-2-carboxylic acid methyl ester
- Product Name
- 5-Aminopyrazine-2-carboxylic acid methyl ester
- CAS No.
- 13924-94-2
- Chemical Name
- 5-Aminopyrazine-2-carboxylic acid methyl ester
- Synonyms
- Methyl 5-Aminopyrazine-2-carboxylate;5-amino-pyrazine-2-carbox...;Methyl 2-amino-5-pyrazinecarboxylate;5-AMino-2-pyrazinecarboxylic Acid Methyl Ester;5-Aminopyrazine-2-carboxylic acid methyl ester;2-Pyrazinecarboxylic acid, 5-amino-, methyl ester;5-aMinopyrazine-2-carboxylic acid Methyl ester HCl;5-aMino-pyrazine-2-carboxylic acid Methyl ester hydrochloride
- CBNumber
- CB22273640
- Molecular Formula
- C6H7N3O2
- Formula Weight
- 153.14
- MOL File
- 13924-94-2.mol
5-Aminopyrazine-2-carboxylic acid methyl ester Property
- Melting point:
- 230-232?C
- Boiling point:
- 363℃
- Density
- 1.319
- Flash point:
- 173℃
- storage temp.
- Keep in dark place,Sealed in dry,2-8°C
- solubility
- DMSO (Slightly), Methanol (Slightly, Heated)
- form
- Solid
- color
- Light Tan to Orange
- InChI
- InChI=1S/C6H7N3O2/c1-11-6(10)4-2-9-5(7)3-8-4/h2-3H,1H3,(H2,7,9)
- InChIKey
- RPEZSZAVQOVHCZ-UHFFFAOYSA-N
- SMILES
- C1(C(OC)=O)=NC=C(N)N=C1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- A628930
- Product name
- 2-Aminopyrazine-5-carboxylicAcidMethylEster
- Packaging
- 2g
- Price
- $550
- Updated
- 2021/12/16
- Product number
- W3046
- Product name
- Methyl5-aminopyrazine-2-carboxylate
- Packaging
- 1g
- Price
- $119
- Updated
- 2021/12/16
- Product number
- FA17840
- Product name
- 2-Aminopyrazine-5-carboxylic acid methyl ester
- Packaging
- 250mg
- Price
- $125
- Updated
- 2021/12/16
- Product number
- 119461
- Product name
- Methyl 5-aminopyrazine-2-carboxylate
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $197
- Updated
- 2021/12/16
- Product number
- FA17840
- Product name
- 2-Aminopyrazine-5-carboxylic acid methyl ester
- Packaging
- 500mg
- Price
- $210
- Updated
- 2021/12/16
5-Aminopyrazine-2-carboxylic acid methyl ester Chemical Properties,Usage,Production
Chemical Properties
Light Tan to Orange Solid
Synthesis
33332-25-1
13924-94-2
General procedure for the synthesis of methyl 5-aminopyrazine-2-carboxylate from methyl 5-chloropyrazine-2-carboxylate: methyl 5-chloropyrazine-2-carboxylate (2 g, 0.0115 mol) was dissolved in 80 mL of dimethyl sulfoxide (DMSO). Sodium azide (3 g, 0.0463 mol) and triphenylphosphine (4.6 g, 0.01738 mol) were added sequentially to the solution, and the reaction mixture was refluxed at 120 °C for 4 hours. After the reaction was completed, 20 mL of 1 N hydrochloric acid solution was added and the reaction was continued at 120 °C for 2 hours. The reaction mixture was cooled to room temperature and neutralized with 90% aqueous sodium bicarbonate solution, followed by extraction of the product with ethyl acetate. The organic phase was dried with anhydrous sodium sulfate and concentrated under reduced pressure to remove the solvent. The residue was washed with n-pentane to give 0.7 g (39.5% yield) of the target compound 5-aminopyrazine-2-carboxylic acid methyl ester as a yellow solid. The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 8.53 (d, J = 1.2 Hz, 1H), 7.91 (d, J = 1.2 Hz, 1H), 7.39 (s, 2H), 3.79 (s, 3H). Elemental analysis (C6H7N3O2) calculated value: [M] 153.14; mass spectrometry (ESI) m/z: [M-H]+ 152.05.
References
[1] European Journal of Pharmaceutical Sciences, 2018, vol. 124, p. 165 - 181
[2] Tetrahedron Letters, 2013, vol. 54, # 5, p. 414 - 418
[3] ACS Medicinal Chemistry Letters, 2013, vol. 4, # 4, p. 414 - 418
5-Aminopyrazine-2-carboxylic acid methyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-Aminopyrazine-2-carboxylic acid methyl ester manufacturers
- Product
- Methyl 5-aminopyrazine-2-carboxylate 13924-94-2
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 97.6%
- Supply Ability
- 100 tons
- Release date
- 2022-01-26
- Product
- 5-Aminopyrazine-2-carboxylic acid methyl ester 13924-94-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2019-12-30