Nalmefene hydrochloride
- Product Name
- Nalmefene hydrochloride
- CAS No.
- 58895-64-0
- Chemical Name
- Nalmefene hydrochloride
- Synonyms
- Revex;NALMEFENE HCL;Unii-K7K69qc05x;Nalmefene Impurity 2;nalmefene hydrochloride;Nalmefene Hydrochloride IMP;Nalmefene Hydrochloride Impurity;(5a)-17-(CyclopropylMethyl)-6-Methylene-4,5-epoxyMorphinan-3,14-diol;(5α)-17-(Cyclopropylmethyl)-4,5-epoxy-6-methylenemorphinan-3,14-diolhydrochloride;17-(cyclopropylmethyl)-4,5alpha-epoxy-6-methylenemorphinan-3,14-diol hydrochloride
- CBNumber
- CB0855103
- Molecular Formula
- C21H26ClNO3
- Formula Weight
- 375.89
- MOL File
- 58895-64-0.mol
Nalmefene hydrochloride Property
- Melting point:
- 180-185°
- storage temp.
- Desiccate at RT
- solubility
- Soluble in Water (up to 25 mg/ml).
- form
- solid
- pka
- 7.63(at 25℃)
- color
- White
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 1 month.
- CAS DataBase Reference
- 58895-64-0
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H317May cause an allergic skin reaction
H332Harmful if inhaled
H334May cause allergy or asthma symptoms or breathing difficulties if inhaled
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P272Contaminated work clothing should not be allowed out of the workplace.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P285In case of inadequate ventilation wear respiratory protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304+P341IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P322Specific measures (see …on this label).
P330Rinse mouth.
P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.
P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 4085
- Product name
- Nalmefenehydrochloride
- Purity
- ≥99%(HPLC)
- Packaging
- 50
- Price
- $118
- Updated
- 2021/12/16
- Product number
- API0009358
- Product name
- NALMEFENE HYDROCHLORIDE
- Purity
- 95.00%
- Packaging
- 1MG
- Price
- $400.43
- Updated
- 2021/12/16
- Product number
- API0009358
- Product name
- NALMEFENE HYDROCHLORIDE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $402.75
- Updated
- 2021/12/16
- Product number
- API0009358
- Product name
- NALMEFENE HYDROCHLORIDE
- Purity
- 95.00%
- Packaging
- 10MG
- Price
- $404.35
- Updated
- 2021/12/16
- Product number
- CD31001381
- Product name
- NalmefeneHydrochloride
- Purity
- 98%
- Packaging
- 250mg
- Price
- $160
- Updated
- 2021/12/16
Nalmefene hydrochloride Chemical Properties,Usage,Production
Description
Nalmefene hydrochloride has been introduced in the U.S.A. for opioid reversal following surgery, and in the reversal of opioid overdoses and epidurally administered narcotics. Nalmefene is an opioid antagonist that inhibits respiratory, analgesic and subjective effects of opioids. It has a higher potency, a longer duration of action, and superior bioavailability than the structurally related naltrexone. Nalmefene has a wide spectrum of biological activity and is in clinical trials for the treatment of interstitial cystitis, recalcitrant pruritus of cholestasis, stroke, rheumatoid arthritis, shock, CNS trauma, and alcoholism. Studies indicate that nalmefene does not induce morphine-like effects and has no apparent abuse potential.
Originator
IVAX (U.S.A.)
Uses
Nalmefene Hydrochloride is a structural analog of Naltrexone (N285780) with opiate antagonist activity used in pharmaceutical treatment of alcoholism. Other pharmacological applications of this compound aim to reduce food cravings, drug abuse and pulmonary disease in affected individuals. Used as an opioid-induced tranquilizer on large animals in the veterinary industry. Narcotic antagonist
brand name
Revex
storage
Desiccate at RT
References
1) Osborn et al. (2010), In vivo characterization of the opioid antagonist nalmefene in mice; Life Sci., 86 624 2) Butelman et al. (2009), Unconditioned behavioral effects of the powerful kappa-opioid hallucinogen salvinorin A in non-human primates: fast onset and entry in cerebrospinal fluid; J. Pharmacol. Exp. Ther., 328 588 3) Butelman et al. (2008), The effects of herkinorin, the first mu-selective ligand from salvinorin A-derived scaffold, in neuroendocrine biomarker assay in nonhuman primates; J. Pharmacol. Exp. Ther., 327 154 4) Soyka and Rosner (2008), Opioid antagonists for pharmacological treatment of alcohol dependence – a critical review; Curr. Drug Abuse Rev., 1 280
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Raw materials
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View Lastest Price from Nalmefene hydrochloride manufacturers
- Product
- Nalmefene hydrochloride 58895-64-0
- Price
- US $35.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 Tons
- Release date
- 2020-11-14
- Product
- Nalmefene hydrochloride 58895-64-0
- Price
- US $2.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2018-12-23