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Butoconazole

Product Name
Butoconazole
CAS No.
64872-76-0
Chemical Name
Butoconazole
Synonyms
BUTONAZOLE;Butooonazole;BUTOCONAZOLE;Butoconazole USP/EP/BP;1-[4-(4-Chlorophenyl)-2-(2,6-dichlorophenyl)sulfanyl-butyl]imidazole;1-[2-[(2,6-Dichlorophenyl)thio]-4-(4-chlorophenyl)butyl]-1H-imidazole;1-[(2S)-4-(4-chlorophenyl)-2-[(2,6-dichlorophenyl)thio]butyl]imidazole;(±)-1-[4-(4-Chlorophenyl)-2-[(2,6-dichlorophenyl)thio]butyl]-1H-imidazole;1-[4-(4-Chlorophenyl)-2-[(2,6-dichlorophenyl)thio]butyl]-1H-imidazole (Butoconazole)
CBNumber
CB3352597
Molecular Formula
C19H17Cl3N2S
Formula Weight
411.78
MOL File
64872-76-0.mol
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Butoconazole Property

Melting point:
68-70.5°
Boiling point:
566.9±50.0 °C(Predicted)
Density 
1.32±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO: 82 mg/mL (199.14 mM);;
pka
6.74±0.12(Predicted)
CAS DataBase Reference
64872-76-0(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
API0024399
Product name
BUTOCONAZOLE
Purity
95.00%
Packaging
0.5G
Price
$214
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0024399
Product name
BUTOCONAZOLE
Purity
95.00%
Packaging
1KG
Price
$9578.3
Updated
2021/12/16
BLDpharm
Product number
BD41915
Product name
Butoconazole
Purity
98%
Packaging
5mg
Price
$36
Updated
2021/12/16
AHH
Product number
MT-48813
Product name
Butoconazole
Purity
98%
Packaging
0.5g
Price
$910
Updated
2021/12/16
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Butoconazole Chemical Properties,Usage,Production

Description

Butoconazole is an imidazole that is pharmacologically quite comparable to clotrimazole. It is a vaginal antifungal agent that increases cell membrane permeability in susceptible fungi. It is indicated for local treatment of vulvovaginal candidiasis (moniliasis).

Uses

Butoconazole is a fungostatic drug, and it is formally classified as an imidazole, but only because of the presence of an imidazole ring in the structure. It is believed that butoconazole, like miconazole, econazole, and other “pure” representatives of the imidazole class, also inhibits the biosynthesis of estrosterin in the cytoplasmatic membrane of fungi; however, it is very possible that this is not the only mechanism of its action. It is effective for vaginal infections caused by various types of candida. It is also used only externally and vaginally. Synonyms of this drug are femstat, listomin, and others.

Uses

antineoplastic, pyrimidine antimetabolite

Definition

ChEBI: A member of the class of imidazoles that is 1H-imidazole in which the hydrogen attached to the nitrogen is substituted by a 4-(4-chlorophenyl)-2-[(2,6-dichlorophenyl)sulfanyl]butyl group. An antifungal agent, it is used as its nitrate sa t in gynaecology for treatment of vulvovaginal infections caused by Candida species, particularly Candida albicans.

Indications

Butoconazole is generally indicated for therapy of vulvovaginal mycoses caused by Candida species and Candida (Torulopsis) glabrata.

brand name

Femstat (Roche);Femstat 3 (Bayer); Gynazole-1 (KV Pharmaceutical).

Antimicrobial activity

Broad-spectrum imidazole antimycotic with in vitro and in vivo activitiy against pathogenic yeasts, dermatophytes, moulds, and dimorphic fungi.

Side effects

Local irritations such as itching and burning sensations and allergic reactions may occur in rare cases and are mainly due to the galenic formulation.

Synthesis

Butoconazole, 1-[4-(4-chlorophenyl)-2-[(2,6-dichlorophenyl)thio]butyl]- 1H-imidazole (35.2.12), is synthesized from 4-chlorobenzylmagnesium bromide, which is reacted with epichloridrine to make 4-(4-chlorophenyl)-1-chlorobutan-2-ol (35.2.10), which is reacted with imidazole in the presence of sodium to make 4-(4-chlorophenyl)- 1-(1H-imidazolyl)butanol-2 (35.2.11). The hydroxyl group in the last is replaced with a chlorine atom upon reaction with thionyl chloride, which is then by the reaction with 2,6- dichlorothiophenol butoconazole, is obtained.

Enzyme inhibitor

This fungicide (FW = 411.78 g/mol; CAS 64872-77-1), also known as Femstat?, Femstat-3?, Gynazole-1?, and systematically as 1-[4- (4- chlorophenyl) -2-[ (2,6-dichlorophenyl) -sulfanyl]butyl]-1H-imidazole (* = chiral center), is believed to inhibit steroid synthesis, targeting the conversion of lanosterol to ergosterol and modifying membrane composition/function. At 80 μM, butoconazole was strictly fungistatic against early stationary-phase Candida albicans cells. During early log- phase growth, butoconazole were highly lethal at 20 μM. In 1995, butoconazole was approved for treatment of vaginal yeast infections.

Butoconazole Preparation Products And Raw materials

Raw materials

Preparation Products

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Butoconazole Suppliers

BTC Pharmaceutical CO. Ltd
Tel
0513-68015-397 15716293042
Fax
0513-68015394
Email
sales14@btcpharm.com
Country
China
ProdList
636
Advantage
55
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2127
Advantage
70
Shanghai TaoSu Biochemical Technology Co., Ltd.
Tel
021-33632979
Fax
021-34692979
Email
info@tsbiochem.com
Country
China
ProdList
8073
Advantage
58
Chengdu HuaXia Chemical Reagent Co. Ltd
Tel
400-1166-196 13458535857
Fax
QQ:800101999
Email
cdhxsj@163.com
Country
China
ProdList
13358
Advantage
58
Kono Chem Co.,Ltd
Tel
13289246953
Fax
029-86107037
Email
info@konochemical.com
Country
China
ProdList
554
Advantage
55
Shandong Xiya Chemical Co., Ltd.
Tel
4009903999 13395398332
Fax
0539-6365991
Email
sales@xiyashiji.com
Country
China
ProdList
20811
Advantage
60
Hubei widely chemical technology Co., Ltd.
Tel
027-83991130 18627774460
Fax
027-83991130
Email
1718093273@qq.com
Country
China
ProdList
1890
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
132020
Advantage
58
Guangdong wengjiang Chemical Reagent Co., Ltd.
Tel
0751-2886750 13927877953
Fax
0751-2886750
Email
3005811397@qq.com
Country
China
ProdList
13482
Advantage
58
Wuhan Netcom Electronic Commerce Limited
Tel
18064670521
Fax
0757-88210752
Email
2355935187@ycphar.com
Country
China
ProdList
4887
Advantage
58
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View Lastest Price from Butoconazole manufacturers

Hebei Mojin Biotechnology Co., Ltd
Product
Butoconazole 64872-76-0
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-08-31
Hebei Guanlang Biotechnology Co., Ltd.
Product
Butoconazole 64872-76-0
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2021-08-30
Dideu Industries Group Limited
Product
Butoconazole 64872-76-0
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons Min
Release date
2021-07-16

64872-76-0, ButoconazoleRelated Search:


  • BUTOCONAZOLE
  • Butooonazole
  • (±)-1-[4-(4-Chlorophenyl)-2-[(2,6-dichlorophenyl)thio]butyl]-1H-imidazole
  • BUTONAZOLE
  • 1-[4-(4-Chlorophenyl)-2-(2,6-dichlorophenyl)sulfanyl-butyl]imidazole
  • 1-[2-[(2,6-Dichlorophenyl)thio]-4-(4-chlorophenyl)butyl]-1H-imidazole
  • 1-[(2S)-4-(4-chlorophenyl)-2-[(2,6-dichlorophenyl)thio]butyl]imidazole
  • Butoconazole USP/EP/BP
  • 1-[4-(4-Chlorophenyl)-2-[(2,6-dichlorophenyl)thio]butyl]-1H-imidazole (Butoconazole)
  • 64872-76-0
  • C19H17Cl3N2S
  • VIDAZA