4-(4-Chloro-benzyl)-2H-phthalazin-1-one
- Product Name
- 4-(4-Chloro-benzyl)-2H-phthalazin-1-one
- CAS No.
- 53242-88-9
- Chemical Name
- 4-(4-Chloro-benzyl)-2H-phthalazin-1-one
- Synonyms
- phthalazin-1(2H);4-(4-Chlorobenzyl);Azelastine USP RC D;AZELASTINE EP IMP D;Vasorelaxant agent-2;Azelastine EP Impurity D;Azelastine Impurity D(USP);Azelastine Related CoMpound D;Phthalazinone Azelastine Analog;Azelastine USP Related Compound D
- CBNumber
- CB0855118
- Molecular Formula
- C15H11ClN2O
- Formula Weight
- 270.71
- MOL File
- 53242-88-9.mol
4-(4-Chloro-benzyl)-2H-phthalazin-1-one Property
- Melting point:
- 206-207 °C(Solv: ethanol (64-17-5))
- Density
- 1.32±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
- pka
- 12.08±0.40(Predicted)
- form
- solid
- color
- White to Off-White
Safety
- HS Code
- 2933998350
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- Y0000328
- Product name
- Azelastine impurity D
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- 5 mg
- Price
- $236
- Updated
- 2025/07/31
- Product number
- PHR2842
- Product name
- Azelastine Related Compound D
- Packaging
- 50MG
- Price
- $588.05
- Updated
- 2025/07/31
- Product number
- 1046191
- Product name
- Azelastine impurity D
- Packaging
- 20mg
- Price
- $1200
- Updated
- 2025/07/31
- Product number
- Y0000328
- Product name
- Azelastine impurity D
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- y0000328
- Price
- $220
- Updated
- 2024/03/01
- Product number
- C378400
- Product name
- 4-[(4-Chlorophenyl)methyl]-1(2H)-phthalazinone
- Packaging
- 2.5g
- Price
- $175
- Updated
- 2021/12/16
4-(4-Chloro-benzyl)-2H-phthalazin-1-one Chemical Properties,Usage,Production
Uses
Stilbene-related heterocyclic compound with anti-HIV activity. A potent vasorelaxant agent.
Synthesis
94801-28-2
53242-88-9
The general procedure for the synthesis of 4-(4-chlorobenzylidene)-1-(2H)-phthalazinone from (E)-3-(4-chlorobenzylidene)isobenzofuran-1(3H)-one was as follows: intermediate 77 (Stage 2) 4-{[4-chlorobenzylidene]methyl}-1(2H)-phthalazinone (3 lb.) was combined with 3-[(4-chlorophenyl)methyl]-2-benzofuran-1(3H)-one (as prepared in Step 1) (10 equiv., corrected for loss on drying) were suspended in ethanol (37 vol.) and heated to about 85 °C under slight reflux. Subsequently, a mixture of a commercially available hydrazine hydrate solution (e.g., 12 eq. from Aldrich) with ethanol (0.63 vol.) was slowly added through a dropping funnel over a period of 1 hour. After the addition was complete, ethanol (0.63 volume) was added again through the dropping funnel. To remove traces of hydrazine hydrate, the reaction suspension was heated at ~85°C for 14 hours at slight reflux. Upon completion of the reaction, it was cooled to about 20 °C and sampled to check the conversion (HPLC showed 99% conversion). Next, acetone (0.35 v/v) was added to the reaction mixture over 30 minutes (note the exothermic reaction). The quenched suspension was stirred for at least 1 hour and then cooled to about 2°C at 30°C. After continued stirring at about 2 °C for 1 h, the product was isolated by filtration through a suction filter and washed with cold ethanol (about 0-5 °C, 3 x 10.9 v/v). The resulting light brown solid was completely dried on a vacuum suction filter protected by nitrogen to give 4-(4-chlorobenzyl)-1-(2H)-phthalazinone in 90-95% yield (corrected by 1H NMR measurements).1H NMR (400 MHz, DMSO-d6) data: δ 4.30 (s, 2H), 7.35 (m, 4H), 7.88 (m, 3H). 8.26 (d, 1H), 12.62 (s, 1H).
References
[1] Patent: WO2007/122156, 2007, A1. Location in patent: Page/Page column 114-115
4-(4-Chloro-benzyl)-2H-phthalazin-1-one Preparation Products And Raw materials
Raw materials
Preparation Products
4-(4-Chloro-benzyl)-2H-phthalazin-1-one Suppliers
- Tel
- --
- Fax
- --
- export@ecochem.dk
- Country
- Europe
- ProdList
- 6371
- Advantage
- 66
- Tel
- --
- Fax
- --
- Sales@kemikalieimport.dk
- Country
- Europe
- ProdList
- 6685
- Advantage
- 47
View Lastest Price from 4-(4-Chloro-benzyl)-2H-phthalazin-1-one manufacturers
- Product
- 4-(4-Chloro-benzyl)-2H-phthalazin-1-one 53242-88-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kgs
- Release date
- 2020-02-13