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Temoporfin

Product Name
Temoporfin
CAS No.
122341-38-2
Chemical Name
Temoporfin
Synonyms
EF 9;MTHPC;Foslip;Fosgel;Foscan;Fospeg;KW2345;Foslipos;m-TrTHPC;temoporfin
CBNumber
CB0855310
Molecular Formula
C44H32N4O4
Formula Weight
680.75
MOL File
122341-38-2.mol
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Temoporfin Property

Melting point:
>250 °C
Density 
1.386±0.06 g/cm3(Predicted)
storage temp. 
Amber Vial, -20°C Freezer, Under inert atmosphere
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
color 
Purple
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H317May cause an allergic skin reaction

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P321Specific treatment (see … on this label).

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
17333
Product name
Temoporfin
Purity
≥95%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
17333
Product name
Temoporfin
Purity
≥95%
Packaging
5mg
Price
$139
Updated
2024/03/01
Cayman Chemical
Product number
17333
Product name
Temoporfin
Purity
≥95%
Packaging
10mg
Price
$243
Updated
2024/03/01
Cayman Chemical
Product number
17333
Product name
Temoporfin
Purity
≥95%
Packaging
25mg
Price
$533
Updated
2024/03/01
TRC
Product number
T017350
Product name
Temoporfin,~90%
Packaging
5mg
Price
$110
Updated
2021/12/16
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Temoporfin Chemical Properties,Usage,Production

Description

Temoporphin, a second generation photosensitizer, was launched in UK for the photodynamic therapy (PDT) of advanced head and neck cancers. This porphyrin derivative can be synthesized from pyrrole and 3-hydroxybenzaldehyde. The pharmacological activity is initiated, 4 days after intravenous injection, by laser-light photoactivation of temoporphin, that has selectively accumulated in cancer tissues. The resulting generation of highly reactive oxygen species leads to malignant cells death thereby inducing tumor necrosis up to a depth of 15 mm. An advantage of temoporphin over other photosensitizing agents is its extreme sensitivity to wavelengths of light that penetrate tissues, resulting in lower light/dose and irradiation time. PDT with intravenous temoporphin has produced relatively high complete and partial response rates in head and neck cancers, with higher response rates generally observed with higher light dose. Temoporphin is well-tolerated and does not preclude surgery/radiotherapy as a later option. Adverse effects were photosensitivity and pain at the injection site.

Originator

Quanta Nova (UK)

Uses

Temoporfin is a synthetic chlorin with light-activated actions. It accumulates in tumor cells and through light activation and oxygen radical formation, it leads to necrosis and cell death.

Uses

Temoporfin is a synthetic chlorin with light-activated actions. When administered systemically, temoporfin accumulates in tumor cells. When stimulated with light (650-652 nm) in the presence of oxygen, reactive oxygen species are generated, leading to necrosis within the tumor. Different approaches to using photodynamic therapy with temoporfin in palliative care are currently of interest.

Definition

ChEBI: Temoporfin is a member of chlorins. It has a role as a photosensitizing agent.

brand name

Foscan

Temoporfin Preparation Products And Raw materials

Raw materials

Preparation Products

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Temoporfin Suppliers

LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2123
Advantage
70
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
Advantage
58
BOC Sciences
Tel
+1-631-485-4226
Fax
1-631-614-7828
Email
inquiry@bocsci.com
Country
United States
ProdList
19553
Advantage
58
Aceschem Inc.
Tel
+1-817863-6948 +1-(817)863-6948
Email
sales@aceschem.com
Country
United States
ProdList
19632
Advantage
58
United States Biological
Tel
--
Fax
--
Email
sales@advtechind.com
Country
United States
ProdList
6075
Advantage
58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
United States Biological
Tel
--
Fax
--
Email
chemicals@usbio.net
Country
United States
ProdList
6214
Advantage
80
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58
Matrix Scientific
Tel
--
Fax
--
Email
sales@matrixscientific.com
Country
United States
ProdList
6632
Advantage
80
Alfa Chemistry
Tel
--
Fax
--
Email
info@Alfa-Chemistry.com
Country
United States
ProdList
6814
Advantage
0
American Custom Chemicals Corporation
Tel
--
Fax
--
Email
sales@acccorporation.com
Country
United States
ProdList
6820
Advantage
51
Waterstone Technology, LLC
Tel
--
Fax
--
Email
sales@waterstonetech.com
Country
United States
ProdList
6786
Advantage
30
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View Lastest Price from Temoporfin manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Temoporfin 122341-38-2
Price
US $0.00-0.00/KG
Min. Order
5mg
Purity
99%HPLC
Supply Ability
2000tons
Release date
2020-01-06
Career Henan Chemical Co
Product
Temoporfin 122341-38-2
Price
US $3.00/ASSAYS
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2019-07-09

122341-38-2, TemoporfinRelated Search:


  • TeMoporfin(KW-2345,EF9)
  • EF 9
  • Foscan
  • Fosgel
  • Foslip
  • Foslipos
  • Fospeg
  • MTHPC
  • 2, 3-dihydro-5,10,15,20-tetra(m-hydroxyphenyl)porphyrin
  • 3,3',3'',3'''-(2,3-dihydroporphyrin -5,10,15,20-tetrayl) tetraphenol
  • 5,10,15,20-tetra(hydroxyphenyl)chlorin
  • m-TrTHPC
  • Temoporphin
  • Temoporfin (m-THPC)
  • temoporfin
  • 8-dihydroporphyrin-5
  • 5,10,15,20-tetra(m-hydroxyphenyl)chlorin
  • 3,3',3'',3'''-(7,8-dihydroporphyrin-5,10,15,20-tetrayl)tetraphenol
  • Phenol,3,3',3'',3'''-(7,8-dihydro-21H,23H-porphine-5,10,15,20-tetrayl)tetrakis-
  • Temoporfin(KW-2345)
  • KW2345
  • 3,3',3'',3'''-(7H,8H-Porphyrin-5,10,15,20-tetrayl)tetraphenol
  • 3,3',3'',3'''-(7H,8H-Porphyrin-5,10,15,20-tetrayl)tetraphenol
  • 122341-38-2
  • C44H32N4O4