methoxamine

Product Name: methoxamine
CAS No.: 390-28-3
Chemical Name: methoxamine
Synonyms: Methoxamin;Methoxamedrine;Methoxamine (6CI);Pseudomethoxamine;methoxamine USP/EP/BP;(2S)-Methoxamine oxalate salt;2-Amino-1-(2,5-dimethoxyphenyl)propan-1-ol;a-(1-Aminoethyl)-2,5-dimethoxybenzyl alcohol;α-(1-Aminoethyl)-2,5-dimethoxybenzyl alcohol;α-(1-Aminoethyl)-2,5-dimethoxybenzenemethanol
CBNumber: CB0882136
Molecular Formula: C11H17NO3
Formula Weight: 211.26
MOL File: 390-28-3.mol

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methoxamine Property

Melting point:: 85-86 °C
Boiling point:: 368.4±42.0 °C(Predicted)
Density: 1.117±0.06 g/cm3(Predicted)
pka: 11.87±0.45(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: BRS0000334
Product name: METHOXAMINE
Purity: 95.00%
Packaging: 5MG
Price: $495.12
Updated: 2021/12/16

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methoxamine Chemical Properties,Usage,Production

Originator

Vasoxyl ,Burroughs-Wellcome,US,1949

Definition

ChEBI: Methoxamine is an amphetamine in which the parent 1-phenylpropan-2-amine skeleton is substituted at position 1 with an hydroxy group and the phenyl ring is 2- and 5-substituted with methoxy groups. It is an antihypotensive agent (pressor), an agonist acting directly at alpha-adrenoceptors with selectivity for the alpha-1 adrenoceptor subtype similar to phenylephrine. It has a role as an antihypotensive agent and an alpha-adrenergic agonist.

Manufacturing Process

2,5-Dimethoxypropiophenone is treated in absolute ether with methyl nitrite and hydrogen chloride. The hydrochloride of 2,5-dimethoxy-αisonitrosopropiophenone crystallizes out of the solution. It is removed, the base is liberated and crystallized from benzene-heptane forming yellow leaflets that melt at about 97° to 98°C. This isonitrosoketone is dissolved in absolute alcohol containing an excess of hydrogen chloride and is hydrogenated with palladized charcoal, yielding β-(2,5-dimethoxyphenyl)-βketoisopropylamine hydrochloride, a salt that melts at about 176°C with decomposition.
12.3 g (1/20 mol) of β-(2,5-dimethoxyphenyl)-β-ketoisopropylamine hydrochloride (MP 176°C) is dissolved in 50 cc of water and hydrogenated with platinum oxide platinum black in the customary Adams-Burgess Parr apparatus. About 1/20 mol of hydrogen is absorbed, after which the solution is filtered off from the catalyst, evaporated to dryness in vacuo and recrystallized from absolute alcohol, absolute ether being added to decrease solubility. The hydrochloride is thus obtained in substantially theoretical yield. It crystallizes in plates and melts at 215°C.

Therapeutic Function

Hypertensive

methoxamine Preparation Products And Raw materials

Raw materials

2,5-DIMETHOXYPROPIOPHENONE

Preparation Products

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methoxamine Suppliers

China 12 France 1 Ukraine 1 United Kingdom 1 United States 3 Global 18

Beijing HuaMeiHuLiBiological Chemical

Tel: 010-56205725
Fax: 010-65763397
Email: waley188@sohu.com
Country: China
ProdList: 12338
Advantage: 58

SynAsst Chemical.

Tel: 021-60343070
Fax: 021-35122006
Country: China
ProdList: 12742
Advantage: 55

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 19892
Advantage: 58

Dideu Industries Group Limited

Tel: +86-29-89586680 +86-15129568250
Email: 1026@dideu.com
Country: China
ProdList: 29423
Advantage: 58

Dayang Chem (Hangzhou) Co.,Ltd.

Tel: 571-88938639 +8617705817739
Fax: +86-571-88938652，+86-571- 88492614
Email: info@dycnchem.com
Country: CHINA
ProdList: 52867
Advantage: 58

Shaanxi Dideu Medichem Co. Ltd

Tel: +86-029-89586680 +86-18192503167
Fax: +86-29-88380327
Email: 1026@dideu.com
Country: China
ProdList: 9507
Advantage: 58

Career Henan Chemica Co

Tel: +86-0371-86658258 15093356674;
Fax: 0371-86658258
Email: laboratory@coreychem.com
Country: China
ProdList: 30255
Advantage: 58

Shaanxi Dideu Medichem Co. Ltd

Tel: +86-29-87569265 +86-18612256290
Fax: 029-88380327
Email: 1056@dideu.com
Country: China
ProdList: 3759
Advantage: 58

Shaanxi DIDU pharmaceutical and Chemical Co., Ltd

Tel: 17691182729 18161915376
Email: 1046@dideu.com
Country: China
ProdList: 10010
Advantage: 58

Shanghai Beiwanta Biotechnology Co., Ltd.

Tel: 021-67187366 19901745723
Email: info@bwtlab.com
Country: China
ProdList: 9240
Advantage: 58

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View Lastest Price from methoxamine manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: methoxamine 390-28-3
Price: US $1.00-1.00/KG
Min. Order: 1g
Purity: 99%
Supply Ability: 50tons
Release date: 2020-05-11

Dideu Industries Group Limited

Product: methoxamine 390-28-3
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons min
Release date: 2021-08-12

390-28-3, methoxamineRelated Search:

Disodium β-glycerophosphate hydrate Adenosine Homovanillic acid Phloroglucinol Trimethoprim Bumetanide Nifedipine 1-(2,6-Dimethylphenoxy)-2-propanamine 2,5-DIMETHOXYBENZYL ALCOHOL Butoxamin METHOXAMINE HYDROCHLORIDE Butoxamine hydrochloride isopropylmethoxamine (+/-)-BUTOXAMINE methoxamine (2,5-DIMETHOXYPHENYL)(2-PIPERIDINYL)METHANOL

Methoxamedrine

2-Amino-1-(2,5-dimethoxyphenyl)propan-1-ol

a-(1-Aminoethyl)-2,5-dimethoxybenzyl alcohol

Benzenemethanol, a-(1-aminoethyl)-2,5-dimethoxy- (9CI)

Benzyl alcohol, a-(1-aminoethyl)-2,5-dimethoxy- (8CI)

Methoxamine (6CI)

Methoxamin

α-(1-Aminoethyl)-2,5-dimethoxybenzenemethanol

α-(1-Aminoethyl)-2,5-dimethoxybenzyl alcohol

alpha-(1-Aminoethyl)-2,5-dimethoxybenzyl alcohol

Benzenemethanol, α-(1-aminoethyl)-2,5-dimethoxy-

methoxamine USP/EP/BP

(2S)-Methoxamine oxalate salt

Pseudomethoxamine

390-28-3