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METHOXAMINE HYDROCHLORIDE

Product Name
METHOXAMINE HYDROCHLORIDE
CAS No.
61-16-5
Chemical Name
METHOXAMINE HYDROCHLORIDE
Synonyms
vasoxyl;Mexan;Vasylox;vasoxine;METHOXAMINE HCL;vasoxylhydrochloride;Naproxen Impurity 47;vasoxinehydrochloride;pressominhydrochloride;Methoxamine hydrochlorid
CBNumber
CB1380846
Molecular Formula
C11H18ClNO3
Formula Weight
247.72
MOL File
61-16-5.mol
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METHOXAMINE HYDROCHLORIDE Property

Melting point:
215℃
refractive index 
1.5204
storage temp. 
2-8°C
solubility 
DMSO (Slightly), Methanol (Slightly)
pka
9.2(at 25℃)
form 
Solid
color 
White to off-white
CAS DataBase Reference
61-16-5(CAS DataBase Reference)
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Safety

WGK Germany 
3
RTECS 
DN4025000
Hazardous Substances Data
61-16-5(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
M6524
Product name
Methoxamine hydrochloride
Packaging
500mg
Price
$187
Updated
2024/03/01
Sigma-Aldrich
Product number
M6524
Product name
Methoxamine hydrochloride
Packaging
1g
Price
$336
Updated
2024/03/01
TRC
Product number
M260740
Product name
MethoxamineHydrochloride(MixtureofDiastereomers)
Packaging
250mg
Price
$160
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0003335
Product name
METHOXAMINE HYDROCHLORIDE
Purity
95.00%
Packaging
0.5G
Price
$538
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
41303
Product name
MethoxamineHCl(MixtureofDiastereomers)
Packaging
250mg
Price
$650
Updated
2021/12/16
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METHOXAMINE HYDROCHLORIDE Chemical Properties,Usage,Production

Originator

Vasoxyl ,Burroughs-Wellcome,US,1949

Uses

Antihypotensive;Alpha adrenergic agonist

Uses

Methoxamine is an α1-adrenergic receptor agonist. It induces vasoconstriction of skin and splanchnic blood vessels, thereby increasing peripheral vascular resistance and raising mean arterial blood pressure.

Uses

anti-fungal

Definition

ChEBI: Methoxamine hydrochloride is a dimethoxybenzene.

Manufacturing Process

2,5-Dimethoxypropiophenone is treated in absolute ether with methyl nitrite and hydrogen chloride. The hydrochloride of 2,5-dimethoxy-αisonitrosopropiophenone crystallizes out of the solution. It is removed, the base is liberated and crystallized from benzene-heptane forming yellow leaflets that melt at about 97° to 98°C. This isonitrosoketone is dissolved in absolute alcohol containing an excess of hydrogen chloride and is hydrogenated with palladized charcoal, yielding β-(2,5-dimethoxyphenyl)-βketoisopropylamine hydrochloride, a salt that melts at about 176°C with decomposition.
12.3 g (1/20 mol) of β-(2,5-dimethoxyphenyl)-β-ketoisopropylamine hydrochloride (MP 176°C) is dissolved in 50 cc of water and hydrogenated with platinum oxide platinum black in the customary Adams-Burgess Parr apparatus. About 1/20 mol of hydrogen is absorbed, after which the solution is filtered off from the catalyst, evaporated to dryness in vacuo and recrystallized from absolute alcohol, absolute ether being added to decrease solubility. The hydrochloride is thus obtained in substantially theoretical yield. It crystallizes in plates and melts at 215°C.

Therapeutic Function

Hypertensive

Biochem/physiol Actions

α1-adrenoceptor agonist.

Safety Profile

Poison by ingestion, intravenous, and intraperitoneal routes. Experimental reproductive effects. An FDA proprietary drug. When heated to decomposition it emits very toxic fumes of HCl and NOx.

METHOXAMINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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METHOXAMINE HYDROCHLORIDE Suppliers

Guangdong Jiabo Pharmaceutical Co.,ltd
Tel
0763-3111768
Fax
0763-6816622
Email
jiabo@jiabopharm.com
Country
China
ProdList
2
Advantage
60
Shanghai Renshi Pharmatech Co., LTD
Tel
021-61150625 17721318029
Fax
021-26018649
Email
info@renshipharma.com
Country
China
ProdList
118
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12984
Advantage
57
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9815
Advantage
79
Hangzhou Yuhao Chemical Technology Co., Ltd
Tel
0571-82693216
Fax
+86-571-82880190
Email
info@yuhaochemical.com
Country
China
ProdList
9387
Advantage
52
Shanghai Jian Chao Chemical Technology Co., Ltd.
Tel
18017383231 18017383231
Fax
qq:2817624287
Email
lyh_antaeus@163.com
Country
China
ProdList
9347
Advantage
55
UHN Shanghai Research & Development Co., Ltd.
Tel
021-58958002 18930822973
Fax
+86 (21) 5895-8628
Email
sales@uhnshanghai.com
Country
China
ProdList
977
Advantage
58
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View Lastest Price from METHOXAMINE HYDROCHLORIDE manufacturers

Career Henan Chemical Co
Product
METHOXAMINE HYDROCHLORIDE 61-16-5
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2019-08-04

61-16-5, METHOXAMINE HYDROCHLORIDERelated Search:


  • vasoxyl
  • vasoxylhydrochloride
  • Methoxamine Hydrochloride (200 mg)
  • 2-aMino-1-(2,5-diMethoxyphenyl)propan-1-ol hydrochloride
  • MethoxaMine Hydrochloride (Mixture of DiastereoMers)
  • BenzeneMethanol,a-(1-aMinoethyl)-2,5-diMethoxy-,hydrochloride (1:1)
  • α-[1-Aminoethyl]-2,5-dimethoxybenzenemethanol hydrochloride
  • α-(1-aminoethyl)-2,5-dimethoxybenzyl alcohol hydrochloride
  • 2-Amino-1-hydroxy-1-(2,5-dimethoxyphenyl)propane hydrochloride
  • a-(a-Aminoethyl)-2,5-dimethoxybenzyl alcohol hydrochloride
  • Benzenemethanol, a-(1-aminoethyl)-2,5-dimethoxy-, hydrochloride (9CI)
  • Benzyl alcohol, a-(1-aminoethyl)-2,5-dimethoxy-, hydrochloride (8CI)
  • Beta-hydroxy-beta-(2,5-dimethoxyphenol)-isopropylamine hydrochloride
  • b-Hydroxy-b-(2,5-dimethoxyphenyl)isopropylamine hydrochloride
  • Vasylox
  • Mexan
  • ALPHA-[1-AMINOETHYL]-2,5-DIMETHOXYBENZYL ALCOHOL HYDROCHLORIDE
  • 1-(2,5-dimethoxyphenyl)-2-aminopropanol
  • 2-amino-1-(2,5-dimethoxyphenyl)-1-propanolhydrochloride
  • alpha-(1-aminoethyl)-2,5-dimethoxy-benzenemethanohydrochloride
  • alpha-(1-aminoethyl)-2,5-dimethoxybenzenemethanolhydrochloride
  • alpha-(1-aminoethyl)-2,5-dimethoxy-benzylalcohohydrochloride
  • Methoxamine hydrochlorid
  • alpha-(alpha-aminoethyl)-2,5-dimethoxybenzylalcoholhydrochloride
  • beta-(2,5-dimethoxyphenyl)-beta-hydroxyisopropylaminehydrochloride
  • beta-hydroxy-beta-(2,5-dimethoxyphenyl)isopropylaminehydrochloride
  • beta-hydroxy-beta-(2,5-dimethoxyphenyl)-isopropylaminehydrochloride
  • pressominhydrochloride
  • vasoxine
  • vasoxinehydrochloride
  • METHOXAMINE HCL
  • METHOXAMINE HYDROCHLORIDE
  • Benzenemethanol,α-(1-aminoethyl)-2,5-dimethoxy-,hydrochloride(1:1)
  • METHOXAMINE HYDROCHLORIDE USP/EP/BP
  • Methoxamine hydrochloride salt
  • Naproxen Impurity 47
  • 61-16-5
  • C11H19Cl2NO3
  • alpha1-adrenoceptor agonist.
  • A type adrenergic receptor stimulants