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METHOXAMINE HYDROCHLORIDE

Product Name
METHOXAMINE HYDROCHLORIDE
CAS No.
61-16-5
Chemical Name
METHOXAMINE HYDROCHLORIDE
Synonyms
vasoxyl;Mexan;Vasylox;vasoxine;METHOXAMINE HCL;vasoxylhydrochloride;Naproxen Impurity 47;vasoxinehydrochloride;pressominhydrochloride;Methoxamine hydrochlorid
CBNumber
CB1380846
Molecular Formula
C11H18ClNO3
Formula Weight
247.72
MOL File
61-16-5.mol
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METHOXAMINE HYDROCHLORIDE Property

Melting point:
215℃
refractive index 
1.5204
storage temp. 
2-8°C
solubility 
DMSO (Slightly), Methanol (Slightly)
pka
9.2(at 25℃)
form 
Solid
CAS DataBase Reference
61-16-5(CAS DataBase Reference)
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Safety

WGK Germany 
3
RTECS 
DN4025000
Hazardous Substances Data
61-16-5(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
M6524
Product name
Methoxamine hydrochloride
Packaging
500mg
Price
$187
Updated
2024/03/01
Sigma-Aldrich
Product number
M6524
Product name
Methoxamine hydrochloride
Packaging
1g
Price
$336
Updated
2024/03/01
TRC
Product number
M260740
Product name
MethoxamineHydrochloride(MixtureofDiastereomers)
Packaging
250mg
Price
$160
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0003335
Product name
METHOXAMINE HYDROCHLORIDE
Purity
95.00%
Packaging
0.5G
Price
$538
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
41303
Product name
MethoxamineHCl(MixtureofDiastereomers)
Packaging
250mg
Price
$650
Updated
2021/12/16
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METHOXAMINE HYDROCHLORIDE Chemical Properties,Usage,Production

Originator

Vasoxyl ,Burroughs-Wellcome,US,1949

Uses

Antihypotensive;Alpha adrenergic agonist

Uses

Methoxamine is an α1-adrenergic receptor agonist. It induces vasoconstriction of skin and splanchnic blood vessels, thereby increasing peripheral vascular resistance and raising mean arterial blood pressure.

Uses

anti-fungal

Definition

ChEBI: Methoxamine hydrochloride is a dimethoxybenzene.

Manufacturing Process

2,5-Dimethoxypropiophenone is treated in absolute ether with methyl nitrite and hydrogen chloride. The hydrochloride of 2,5-dimethoxy-αisonitrosopropiophenone crystallizes out of the solution. It is removed, the base is liberated and crystallized from benzene-heptane forming yellow leaflets that melt at about 97° to 98°C. This isonitrosoketone is dissolved in absolute alcohol containing an excess of hydrogen chloride and is hydrogenated with palladized charcoal, yielding β-(2,5-dimethoxyphenyl)-βketoisopropylamine hydrochloride, a salt that melts at about 176°C with decomposition.
12.3 g (1/20 mol) of β-(2,5-dimethoxyphenyl)-β-ketoisopropylamine hydrochloride (MP 176°C) is dissolved in 50 cc of water and hydrogenated with platinum oxide platinum black in the customary Adams-Burgess Parr apparatus. About 1/20 mol of hydrogen is absorbed, after which the solution is filtered off from the catalyst, evaporated to dryness in vacuo and recrystallized from absolute alcohol, absolute ether being added to decrease solubility. The hydrochloride is thus obtained in substantially theoretical yield. It crystallizes in plates and melts at 215°C.

Therapeutic Function

Hypertensive

Biochem/physiol Actions

α1-adrenoceptor agonist.

Safety Profile

Poison by ingestion, intravenous, and intraperitoneal routes. Experimental reproductive effects. An FDA proprietary drug. When heated to decomposition it emits very toxic fumes of HCl and NOx.

METHOXAMINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from METHOXAMINE HYDROCHLORIDE manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
MethoxaMine Hydrochloride 61-16-5
Price
US $1.00-1.00/KG
Min. Order
1g
Purity
99%
Supply Ability
50tons
Release date
2020-05-11
Career Henan Chemical Co
Product
METHOXAMINE HYDROCHLORIDE 61-16-5
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2019-08-04

61-16-5, METHOXAMINE HYDROCHLORIDERelated Search:

2,5-Dimethoxyphenethylamine hydrochloride 2,5-DIMETHOXYBENZYL ALCOHOL 2-Methoxyphenethylamine Norfenefrine hydrochloride methoxamine 2-Amino-1-(2,5-dimethoxyphenyl)ethanol N-desmethylmethoxyphenamine Butoxamine hydrochloride METHOXAMINE HYDROCHLORIDE ISOPROPYLAMINE HYDROCHLORIDE 2-AMINO-1-(3-METHOXY-PHENYL)-ETHANOL HCL 2-(2-aminopropyl)phenol 2-amino-1-(3-methoxyphenyl)ethanol 2-AMINO-1-(2-METHOXY-PHENYL)-ETHANOL HCL 2-AMINO-1-(2-METHOXYPHENYL)ETHANOL 2-HYDROXY-5-METHOXYBENZYL ALCOHOL 1-(2,5-DIMETHOXYPHENYL)-2-AMINOPROPANEHYDROCHLORIDE 2-(2-aminoethyl)phenol

  • vasoxyl
  • vasoxylhydrochloride
  • Methoxamine Hydrochloride (200 mg)
  • 2-aMino-1-(2,5-diMethoxyphenyl)propan-1-ol hydrochloride
  • MethoxaMine Hydrochloride (Mixture of DiastereoMers)
  • BenzeneMethanol,a-(1-aMinoethyl)-2,5-diMethoxy-,hydrochloride (1:1)
  • α-[1-Aminoethyl]-2,5-dimethoxybenzenemethanol hydrochloride
  • α-(1-aminoethyl)-2,5-dimethoxybenzyl alcohol hydrochloride
  • 2-Amino-1-hydroxy-1-(2,5-dimethoxyphenyl)propane hydrochloride
  • a-(a-Aminoethyl)-2,5-dimethoxybenzyl alcohol hydrochloride
  • Benzenemethanol, a-(1-aminoethyl)-2,5-dimethoxy-, hydrochloride (9CI)
  • Benzyl alcohol, a-(1-aminoethyl)-2,5-dimethoxy-, hydrochloride (8CI)
  • Beta-hydroxy-beta-(2,5-dimethoxyphenol)-isopropylamine hydrochloride
  • b-Hydroxy-b-(2,5-dimethoxyphenyl)isopropylamine hydrochloride
  • Vasylox
  • Mexan
  • ALPHA-[1-AMINOETHYL]-2,5-DIMETHOXYBENZYL ALCOHOL HYDROCHLORIDE
  • 1-(2,5-dimethoxyphenyl)-2-aminopropanol
  • 2-amino-1-(2,5-dimethoxyphenyl)-1-propanolhydrochloride
  • alpha-(1-aminoethyl)-2,5-dimethoxy-benzenemethanohydrochloride
  • alpha-(1-aminoethyl)-2,5-dimethoxybenzenemethanolhydrochloride
  • alpha-(1-aminoethyl)-2,5-dimethoxy-benzylalcohohydrochloride
  • Methoxamine hydrochlorid
  • alpha-(alpha-aminoethyl)-2,5-dimethoxybenzylalcoholhydrochloride
  • beta-(2,5-dimethoxyphenyl)-beta-hydroxyisopropylaminehydrochloride
  • beta-hydroxy-beta-(2,5-dimethoxyphenyl)isopropylaminehydrochloride
  • beta-hydroxy-beta-(2,5-dimethoxyphenyl)-isopropylaminehydrochloride
  • pressominhydrochloride
  • vasoxine
  • vasoxinehydrochloride
  • METHOXAMINE HCL
  • METHOXAMINE HYDROCHLORIDE
  • Benzenemethanol,α-(1-aminoethyl)-2,5-dimethoxy-,hydrochloride(1:1)
  • METHOXAMINE HYDROCHLORIDE USP/EP/BP
  • Methoxamine hydrochloride salt
  • Naproxen Impurity 47
  • 61-16-5
  • C11H19Cl2NO3
  • alpha1-adrenoceptor agonist.
  • A type adrenergic receptor stimulants