ChemicalBook > CAS DataBase List > METHOXAMINE HYDROCHLORIDE

METHOXAMINE HYDROCHLORIDE

Product Name: METHOXAMINE HYDROCHLORIDE
CAS No.: 61-16-5
Chemical Name: METHOXAMINE HYDROCHLORIDE
Synonyms: vasoxyl;Mexan;Vasylox;vasoxine;METHOXAMINE HCL;vasoxylhydrochloride;Naproxen Impurity 47;vasoxinehydrochloride;pressominhydrochloride;Methoxamine hydrochlorid
CBNumber: CB1380846
Molecular Formula: C11H18ClNO3
Formula Weight: 247.72
MOL File: 61-16-5.mol

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METHOXAMINE HYDROCHLORIDE Property

Melting point:: 215℃
refractive index: 1.5204
storage temp.: 2-8°C
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 9.2(at 25℃)
form: Solid
color: White to off-white
InChI: InChI=1S/C11H17NO3.ClH/c1-7(12)11(13)9-6-8(14-2)4-5-10(9)15-3;/h4-7,11,13H,12H2,1-3H3;1H
InChIKey: YGRFXPCHZBRUKP-UHFFFAOYSA-N
SMILES: C1(=CC(=CC=C1OC)OC)C(O)C(N)C.Cl
CAS DataBase Reference: 61-16-5(CAS DataBase Reference)

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Safety

WGK Germany: 3
RTECS: DN4025000
Hazardous Substances Data: 61-16-5(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: M6524
Product name: Methoxamine hydrochloride
Packaging: 500mg
Price: $193
Updated: 2025/07/31

Sigma-Aldrich

Product number: M6524
Product name: Methoxamine hydrochloride
Packaging: 1g
Price: $343.9
Updated: 2025/07/31

TRC

Product number: M260740
Product name: MethoxamineHydrochloride(MixtureofDiastereomers)
Packaging: 250mg
Price: $160
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0003335
Product name: METHOXAMINE HYDROCHLORIDE
Purity: 95.00%
Packaging: 0.5G
Price: $538
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 41303
Product name: MethoxamineHCl(MixtureofDiastereomers)
Packaging: 250mg
Price: $650
Updated: 2021/12/16

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METHOXAMINE HYDROCHLORIDE Chemical Properties,Usage,Production

Originator

Vasoxyl ,Burroughs-Wellcome,US,1949

Uses

Antihypotensive;Alpha adrenergic agonist

Uses

Methoxamine is an α1-adrenergic receptor agonist. It induces vasoconstriction of skin and splanchnic blood vessels, thereby increasing peripheral vascular resistance and raising mean arterial blood pressure.

Uses

anti-fungal

Definition

ChEBI: Methoxamine hydrochloride is a dimethoxybenzene.

Manufacturing Process

2,5-Dimethoxypropiophenone is treated in absolute ether with methyl nitrite and hydrogen chloride. The hydrochloride of 2,5-dimethoxy-αisonitrosopropiophenone crystallizes out of the solution. It is removed, the base is liberated and crystallized from benzene-heptane forming yellow leaflets that melt at about 97° to 98°C. This isonitrosoketone is dissolved in absolute alcohol containing an excess of hydrogen chloride and is hydrogenated with palladized charcoal, yielding β-(2,5-dimethoxyphenyl)-βketoisopropylamine hydrochloride, a salt that melts at about 176°C with decomposition.
12.3 g (1/20 mol) of β-(2,5-dimethoxyphenyl)-β-ketoisopropylamine hydrochloride (MP 176°C) is dissolved in 50 cc of water and hydrogenated with platinum oxide platinum black in the customary Adams-Burgess Parr apparatus. About 1/20 mol of hydrogen is absorbed, after which the solution is filtered off from the catalyst, evaporated to dryness in vacuo and recrystallized from absolute alcohol, absolute ether being added to decrease solubility. The hydrochloride is thus obtained in substantially theoretical yield. It crystallizes in plates and melts at 215°C.

Therapeutic Function

Hypertensive

Biochem/physiol Actions

α1-adrenoceptor agonist.

Safety Profile

Poison by ingestion, intravenous, and intraperitoneal routes. Experimental reproductive effects. An FDA proprietary drug. When heated to decomposition it emits very toxic fumes of HCl and NOx.

METHOXAMINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from METHOXAMINE HYDROCHLORIDE manufacturers

Career Henan Chemical Co

Product: METHOXAMINE HYDROCHLORIDE 61-16-5
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2019-08-04

61-16-5, METHOXAMINE HYDROCHLORIDERelated Search:

2,5-Dimethoxyphenethylamine hydrochloride 2,5-DIMETHOXYBENZYL ALCOHOL 2-Methoxyphenethylamine Norfenefrine hydrochloride methoxamine 2-Amino-1-(2,5-dimethoxyphenyl)ethanol N-desmethylmethoxyphenamine Butoxamine hydrochloride METHOXAMINE HYDROCHLORIDE ISOPROPYLAMINE HYDROCHLORIDE 2-AMINO-1-(3-METHOXY-PHENYL)-ETHANOL HCL 2-(2-aminopropyl)phenol 2-amino-1-(3-methoxyphenyl)ethanol 2-AMINO-1-(2-METHOXY-PHENYL)-ETHANOL HCL 2-AMINO-1-(2-METHOXYPHENYL)ETHANOL 2-HYDROXY-5-METHOXYBENZYL ALCOHOL 1-(2,5-DIMETHOXYPHENYL)-2-AMINOPROPANEHYDROCHLORIDE 2-(2-aminoethyl)phenol

vasoxyl

vasoxylhydrochloride

Methoxamine Hydrochloride (200 mg)

2-aMino-1-(2,5-diMethoxyphenyl)propan-1-ol hydrochloride

MethoxaMine Hydrochloride (Mixture of DiastereoMers)

BenzeneMethanol,a-(1-aMinoethyl)-2,5-diMethoxy-,hydrochloride (1:1)

α-[1-Aminoethyl]-2,5-dimethoxybenzenemethanol hydrochloride

α-(1-aminoethyl)-2,5-dimethoxybenzyl alcohol hydrochloride

2-Amino-1-hydroxy-1-(2,5-dimethoxyphenyl)propane hydrochloride

a-(a-Aminoethyl)-2,5-dimethoxybenzyl alcohol hydrochloride

Benzenemethanol, a-(1-aminoethyl)-2,5-dimethoxy-, hydrochloride (9CI)

Benzyl alcohol, a-(1-aminoethyl)-2,5-dimethoxy-, hydrochloride (8CI)

Beta-hydroxy-beta-(2,5-dimethoxyphenol)-isopropylamine hydrochloride

b-Hydroxy-b-(2,5-dimethoxyphenyl)isopropylamine hydrochloride

Vasylox

Mexan

ALPHA-[1-AMINOETHYL]-2,5-DIMETHOXYBENZYL ALCOHOL HYDROCHLORIDE

1-(2,5-dimethoxyphenyl)-2-aminopropanol

2-amino-1-(2,5-dimethoxyphenyl)-1-propanolhydrochloride

alpha-(1-aminoethyl)-2,5-dimethoxy-benzenemethanohydrochloride

alpha-(1-aminoethyl)-2,5-dimethoxybenzenemethanolhydrochloride

alpha-(1-aminoethyl)-2,5-dimethoxy-benzylalcohohydrochloride

Methoxamine hydrochlorid

alpha-(alpha-aminoethyl)-2,5-dimethoxybenzylalcoholhydrochloride

beta-(2,5-dimethoxyphenyl)-beta-hydroxyisopropylaminehydrochloride

beta-hydroxy-beta-(2,5-dimethoxyphenyl)isopropylaminehydrochloride

beta-hydroxy-beta-(2,5-dimethoxyphenyl)-isopropylaminehydrochloride

pressominhydrochloride

vasoxine

vasoxinehydrochloride

METHOXAMINE HCL

METHOXAMINE HYDROCHLORIDE

Benzenemethanol,α-(1-aminoethyl)-2,5-dimethoxy-,hydrochloride(1:1)

METHOXAMINE HYDROCHLORIDE USP/EP/BP

Methoxamine hydrochloride salt

Naproxen Impurity 47

Methoxamine hydrochloride, 10 mM in DMSO

61-16-5

C11H19Cl2NO3

alpha1-adrenoceptor agonist.

A type adrenergic receptor stimulants