methoxamine

Product Name: methoxamine
CAS No.: 390-28-3
Chemical Name: methoxamine
Synonyms: Methoxamin;Methoxamedrine;Methoxamine (6CI);Pseudomethoxamine;methoxamine USP/EP/BP;(2S)-Methoxamine oxalate salt;2-Amino-1-(2,5-dimethoxyphenyl)propan-1-ol;a-(1-Aminoethyl)-2,5-dimethoxybenzyl alcohol;α-(1-Aminoethyl)-2,5-dimethoxybenzyl alcohol;α-(1-Aminoethyl)-2,5-dimethoxybenzenemethanol
CBNumber: CB0882136
Molecular Formula: C11H17NO3
Formula Weight: 211.26
MOL File: 390-28-3.mol

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methoxamine Property

Melting point:: 85-86 °C
Boiling point:: 368.4±42.0 °C(Predicted)
Density: 1.117±0.06 g/cm3(Predicted)
pka: 11.87±0.45(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: BRS0000334
Product name: METHOXAMINE
Purity: 95.00%
Packaging: 5MG
Price: $495.12
Updated: 2021/12/16

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methoxamine Chemical Properties,Usage,Production

Originator

Vasoxyl ,Burroughs-Wellcome,US,1949

Definition

ChEBI: Methoxamine is an amphetamine in which the parent 1-phenylpropan-2-amine skeleton is substituted at position 1 with an hydroxy group and the phenyl ring is 2- and 5-substituted with methoxy groups. It is an antihypotensive agent (pressor), an agonist acting directly at alpha-adrenoceptors with selectivity for the alpha-1 adrenoceptor subtype similar to phenylephrine. It has a role as an antihypotensive agent and an alpha-adrenergic agonist.

Manufacturing Process

2,5-Dimethoxypropiophenone is treated in absolute ether with methyl nitrite and hydrogen chloride. The hydrochloride of 2,5-dimethoxy-αisonitrosopropiophenone crystallizes out of the solution. It is removed, the base is liberated and crystallized from benzene-heptane forming yellow leaflets that melt at about 97° to 98°C. This isonitrosoketone is dissolved in absolute alcohol containing an excess of hydrogen chloride and is hydrogenated with palladized charcoal, yielding β-(2,5-dimethoxyphenyl)-βketoisopropylamine hydrochloride, a salt that melts at about 176°C with decomposition.
12.3 g (1/20 mol) of β-(2,5-dimethoxyphenyl)-β-ketoisopropylamine hydrochloride (MP 176°C) is dissolved in 50 cc of water and hydrogenated with platinum oxide platinum black in the customary Adams-Burgess Parr apparatus. About 1/20 mol of hydrogen is absorbed, after which the solution is filtered off from the catalyst, evaporated to dryness in vacuo and recrystallized from absolute alcohol, absolute ether being added to decrease solubility. The hydrochloride is thus obtained in substantially theoretical yield. It crystallizes in plates and melts at 215°C.

Therapeutic Function

Hypertensive

methoxamine Preparation Products And Raw materials

Raw materials

2,5-DIMETHOXYPROPIOPHENONE

Preparation Products

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methoxamine Suppliers

China 15 France 1 Ukraine 1 United Kingdom 1 United States 3 Global 21

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390-28-3, methoxamineRelated Search:

Disodium β-glycerophosphate hydrate Adenosine Homovanillic acid Phloroglucinol Trimethoprim Bumetanide Nifedipine 1-(2,6-Dimethylphenoxy)-2-propanamine 2,5-DIMETHOXYBENZYL ALCOHOL Butoxamin METHOXAMINE HYDROCHLORIDE Butoxamine hydrochloride isopropylmethoxamine (+/-)-BUTOXAMINE methoxamine (2,5-DIMETHOXYPHENYL)(2-PIPERIDINYL)METHANOL

Methoxamedrine

2-Amino-1-(2,5-dimethoxyphenyl)propan-1-ol

a-(1-Aminoethyl)-2,5-dimethoxybenzyl alcohol

Benzenemethanol, a-(1-aminoethyl)-2,5-dimethoxy- (9CI)

Benzyl alcohol, a-(1-aminoethyl)-2,5-dimethoxy- (8CI)

Methoxamine (6CI)

Methoxamin

α-(1-Aminoethyl)-2,5-dimethoxybenzenemethanol

α-(1-Aminoethyl)-2,5-dimethoxybenzyl alcohol

alpha-(1-Aminoethyl)-2,5-dimethoxybenzyl alcohol

Benzenemethanol, α-(1-aminoethyl)-2,5-dimethoxy-

methoxamine USP/EP/BP

(2S)-Methoxamine oxalate salt

Pseudomethoxamine

390-28-3