ChemicalBook > CAS DataBase List > 4-methyl hydrogen D-aspartate hydrochloride

4-methyl hydrogen D-aspartate hydrochloride

Product Name: 4-methyl hydrogen D-aspartate hydrochloride
CAS No.: 22728-89-8
Chemical Name: 4-methyl hydrogen D-aspartate hydrochloride
Synonyms: B-methylesterD-aspartateHCl;BETA-METHYLESTER-D-ASPARTATEHCL;B-methylesterD-aspartatehydrochloride;β-Methyl (2R)-aspartate ester hydrochloride;4-methyl hydrogen D-aspartate hydrochloride;D-Aspartic acid-b-methyl ester hydrochloride;(R)-2-Amino-4-methoxy-4-oxobutanoic acid hydrochloride;(2R)-2-amino-4-methoxy-4-oxobutanoic acid hydrochloride;D-Aspartic Acid 4-Methyl Ester Hydrochloride D-Aspartic Acid 4-Methyl Ester Hydrochloride
CBNumber: CB0884817
Molecular Formula: C5H11ClNO4
Formula Weight: 184.59814
MOL File: 22728-89-8.mol

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4-methyl hydrogen D-aspartate hydrochloride Property

storage temp.: Sealed in dry,Room Temperature
Appearance: White to off-white Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TRC

Product number: A788940
Product name: D-AsparticAcid4-MethylEsterHydrochloride
Packaging: 10g
Price: $165
Updated: 2021/12/16

AK Scientific

Product number: 1404AB
Product name: D-Asparticacid-beta-methylesterhydrochloride
Packaging: 25g
Price: $181
Updated: 2021/12/16

Activate Scientific

Product number: AS112865
Product name: D-Aspartic acid-b-methyl ester hydrochloride
Purity: 97%
Packaging: 25g
Price: $238
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: AAA0002800
Product name: D-ASPARTIC ACID-BETA-METHYL ESTER HYDROCHLORIDE
Purity: 95.00%
Packaging: 5MG
Price: $503.67
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: AAA0002800
Product name: D-ASPARTIC ACID-BETA-METHYL ESTER HYDROCHLORIDE
Purity: 95.00%
Packaging: 1G
Price: $600
Updated: 2021/12/16

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4-methyl hydrogen D-aspartate hydrochloride Chemical Properties,Usage,Production

Uses

D-Aspartic acid 4-methyl ester is a protected form of D-Aspartic acid (A790020). D-Aspartic acid is the unnatural isomer of L-Aspartic acid (A790024). D-Aspartic acid naturally occurs in human ovarian follicular fluid, and is thought to be linked to oocyte quality. It is also found in the white matter of human brains, more specifically in myelin proteins.

Synthesis

67-56-1

1783-96-6

22728-89-8

The general procedure for the synthesis of (R)-2-amino-4-methoxy-4-oxobutanoic acid hydrochloride from methanol and D-aspartic acid was as follows: D-aspartic acid (160 g, 1.2 mol) was suspended in 850 mL of methanol and cooled to -5 to 0°C. Thionyl chloride (178.4 g, 1.5 mol) was added slowly dropwise with stirring. After completion of the dropwise addition, the reaction mixture was slowly warmed to 25 to 35°C and the reaction was continued with stirring for 4 to 5 hours. Upon completion of the reaction, the methanol was removed by distillation under reduced pressure. The resulting white solid was washed with stirring in 500 mL of ethyl acetate for 0.5 h. Subsequent filtration and drying afforded the target product (R)-2-amino-4-methoxy-4-oxobutanoic acid hydrochloride (Compound of Formula II) 192 g in 87% yield with a melting point of 185 to 186°C. The reaction mixture was slowly warmed to 25 to 35°C for 4 to 5 hours.

References

[1] Journal of the Chemical Society - Perkin Transactions 1, 1997, # 17, p. 2513 - 2526
[2] Patent: CN103992337, 2016, B. Location in patent: Paragraph 0031; 0032
[3] Patent: CN104497010, 2016, B. Location in patent: Paragraph 0035; 0036; 0037
[4] Journal of Medicinal Chemistry, 1994, vol. 37, # 5, p. 674 - 688

4-methyl hydrogen D-aspartate hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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22728-89-8, 4-methyl hydrogen D-aspartate hydrochlorideRelated Search:

H-D-ASP(OBZL)-OH D-ASPARTIC ACID-BETA-METHYL ESTER D-Aspartic Acid diethyl ester hydrochloride H-D-Asp(OEt)-OtBu.Hcl H-D-Asp(OtBu)-OMe·HCl H-D-Asp(OEt)-OH D-ASPARTIC ACID(OBZL)-OBZL P-TOSYLATE D-Aspartic acid, 4-(1,1-dimethylethyl) 1-methyl ester H-D-Asp(Otbu)-(O-2-PhiPr) H-D-Asp(OtBu)-OtBu · HCl

D-Aspartic acid-b-methyl ester hydrochloride

4-methyl hydrogen D-aspartate hydrochloride

B-methylesterD-aspartateHCl

B-methylesterD-aspartatehydrochloride

BETA-METHYLESTER-D-ASPARTATEHCL

β-Methyl (2R)-aspartate ester hydrochloride

(R)-2-Amino-4-methoxy-4-oxobutanoic acid hydrochloride

(2R)-2-amino-4-methoxy-4-oxobutanoic acid hydrochloride

D-Aspartic Acid 4-Methyl Ester Hydrochloride D-Aspartic Acid 4-Methyl Ester Hydrochloride

22728-89-8