4-methyl hydrogen D-aspartate hydrochloride
- Product Name
- 4-methyl hydrogen D-aspartate hydrochloride
- CAS No.
- 22728-89-8
- Chemical Name
- 4-methyl hydrogen D-aspartate hydrochloride
- Synonyms
- B-methylesterD-aspartateHCl;BETA-METHYLESTER-D-ASPARTATEHCL;B-methylesterD-aspartatehydrochloride;β-Methyl (2R)-aspartate ester hydrochloride;4-methyl hydrogen D-aspartate hydrochloride;D-Aspartic acid-b-methyl ester hydrochloride;(R)-2-Amino-4-methoxy-4-oxobutanoic acid hydrochloride;(2R)-2-amino-4-methoxy-4-oxobutanoic acid hydrochloride;D-Aspartic Acid 4-Methyl Ester Hydrochloride D-Aspartic Acid 4-Methyl Ester Hydrochloride
- CBNumber
- CB0884817
- Molecular Formula
- C5H11ClNO4
- Formula Weight
- 184.59814
- MOL File
- 22728-89-8.mol
4-methyl hydrogen D-aspartate hydrochloride Property
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- A788940
- Product name
- D-AsparticAcid4-MethylEsterHydrochloride
- Packaging
- 10g
- Price
- $165
- Updated
- 2021/12/16
- Product number
- 1404AB
- Product name
- D-Asparticacid-beta-methylesterhydrochloride
- Packaging
- 25g
- Price
- $181
- Updated
- 2021/12/16
- Product number
- AS112865
- Product name
- D-Aspartic acid-b-methyl ester hydrochloride
- Purity
- 97%
- Packaging
- 25g
- Price
- $238
- Updated
- 2021/12/16
- Product number
- AAA0002800
- Product name
- D-ASPARTIC ACID-BETA-METHYL ESTER HYDROCHLORIDE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $503.67
- Updated
- 2021/12/16
- Product number
- AAA0002800
- Product name
- D-ASPARTIC ACID-BETA-METHYL ESTER HYDROCHLORIDE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $600
- Updated
- 2021/12/16
4-methyl hydrogen D-aspartate hydrochloride Chemical Properties,Usage,Production
Uses
D-Aspartic acid 4-methyl ester is a protected form of D-Aspartic acid (A790020). D-Aspartic acid is the unnatural isomer of L-Aspartic acid (A790024). D-Aspartic acid naturally occurs in human ovarian follicular fluid, and is thought to be linked to oocyte quality. It is also found in the white matter of human brains, more specifically in myelin proteins.
Synthesis
67-56-1
1783-96-6
22728-89-8
The general procedure for the synthesis of (R)-2-amino-4-methoxy-4-oxobutanoic acid hydrochloride from methanol and D-aspartic acid was as follows: D-aspartic acid (160 g, 1.2 mol) was suspended in 850 mL of methanol and cooled to -5 to 0°C. Thionyl chloride (178.4 g, 1.5 mol) was added slowly dropwise with stirring. After completion of the dropwise addition, the reaction mixture was slowly warmed to 25 to 35°C and the reaction was continued with stirring for 4 to 5 hours. Upon completion of the reaction, the methanol was removed by distillation under reduced pressure. The resulting white solid was washed with stirring in 500 mL of ethyl acetate for 0.5 h. Subsequent filtration and drying afforded the target product (R)-2-amino-4-methoxy-4-oxobutanoic acid hydrochloride (Compound of Formula II) 192 g in 87% yield with a melting point of 185 to 186°C. The reaction mixture was slowly warmed to 25 to 35°C for 4 to 5 hours.
References
[1] Journal of the Chemical Society - Perkin Transactions 1, 1997, # 17, p. 2513 - 2526
[2] Patent: CN103992337, 2016, B. Location in patent: Paragraph 0031; 0032
[3] Patent: CN104497010, 2016, B. Location in patent: Paragraph 0035; 0036; 0037
[4] Journal of Medicinal Chemistry, 1994, vol. 37, # 5, p. 674 - 688
4-methyl hydrogen D-aspartate hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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