iproniazid
- Product Name
- iproniazid
- CAS No.
- 54-92-2
- Chemical Name
- iproniazid
- Synonyms
- IPRAZID;Marsilid;iproniazid;Iproniazid>n’-isopropylisonicotinohydrazide;1-Isonicotinoyl-2-isopropylhydrazine;N'-Isopropylpyridine-4-Carbohydrazide;Isonicotinic Acid 2-Isopropylhydrazide;N'-propan-2-ylpyridine-4-carbohydrazide;Isonicotinic acid N'-isopropyl-hydrazide
- CBNumber
- CB0928533
- Molecular Formula
- C9H13N3O
- Formula Weight
- 179.22
- MOL File
- 54-92-2.mol
iproniazid Property
- Melting point:
- 112.5-113.5°
- Boiling point:
- 311.75°C (rough estimate)
- Density
- 1.1305 (rough estimate)
- refractive index
- 1.5100 (estimate)
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- 11.28±0.23(Predicted)
- form
- Solid
- color
- Pale Beige
- CAS DataBase Reference
- 54-92-2
Safety
- HS Code
- 2933399990
- Toxicity
- An isopropyl derivative of isoniazid that was found to have mood-elevating effects in tuberculosis patients. It was later found to be a monoamine oxidase (MAO) inhibitor and, although not currently approved for clinical use as an antidepressant due to its propensity to cause liver damage it led to the development of other MAO inhibitors currently in use. In addition to hepatotoxic effects, iproniazid is a hypotensive agent and can cause potentially hazardous reactions with other drugs and amine-rich foods.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 014945
- Product name
- Iproniazid
- Packaging
- 500mg
- Price
- $446
- Updated
- 2021/12/16
- Product number
- I746500
- Product name
- Iproniazid
- Packaging
- 5g
- Price
- $1110
- Updated
- 2021/12/16
- Product number
- 145053
- Product name
- N'-Isopropylisonicotinohydrazide
- Purity
- 95%
- Packaging
- 5g
- Price
- $1601
- Updated
- 2021/12/16
- Product number
- 59217
- Product name
- Iproniazid
- Packaging
- 5G
- Price
- $2120
- Updated
- 2021/12/16
- Product number
- 145053
- Product name
- N'-Isopropylisonicotinohydrazide
- Purity
- 95%
- Packaging
- 25g
- Price
- $4801
- Updated
- 2021/12/16
iproniazid Chemical Properties,Usage,Production
Originator
Marsilid,Roche,US,1952
Uses
Iproniazid is a hydrazine based drug used as an antidepressant. Iproniazid acts as an irreversible and nonselective monoamine oxidase inhibitor.
Definition
ChEBI: Iproniazid is a carbohydrazide and a member of pyridines.
Manufacturing Process
A mixture of 40 g of isonicotinyl hydrazine and 600 cc of acetone was heated
on a steam bath until solution was complete. Upon cooling the reaction
mixture, 1-isonicotinyl-2-isopropylidene hydrazine precipitated in the form of
white needles; MP 161°C to 161.5°C.
A solution of 20 g of 1-isonicotinyl-2-isopropylidene hydrazine in 150 cc of
methanol was reduced with hydrogen at room temperature and 50 psi using
300 mg of platinum black as a catalyst.
brand name
Euphozid;Ipropran;Isotamine;Laniazid;Marsilid;Nydrazid;P-1-n forte;Pms isoniazid;Rifamate;Rimactane;Rimifon;Ro 7-1554;Teebaconin;Triniad;Uniad.
Therapeutic Function
Antidepressant, Monoamine oxidase inhibitor
World Health Organization (WHO)
Iproniazid, a monoamine oxidase inhibitor (MAOI), was introduced in 1952 for the treatment of depressive illness. Subsequently concern regarding potentially serious interactions between MAOIs and foods containing tyramine inspired much restrictive regulatory action. However, MAOIs still retain a place in the treatment of serious depressive illness although there is no international consensus on which compounds should be preferred. Thus iproniazid remains available in several countries.
Purification Methods
Crystallise it from *benzene or *benzene /pet ether and dry it in a vacuum. It is soluble in H2O and EtOH. [Fox & Gibas J Org Chem 18 994 1953.] The dihydrochloride has m 227-228o (from EtOH). [Beilstein 22 III/IV 551.] It is an antidepressant.
iproniazid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from iproniazid manufacturers
- Product
- iproniazid 54-92-2
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99.5%
- Supply Ability
- 100 tons
- Release date
- 2022-02-18
- Product
- iproniazid 54-92-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 100kg
- Release date
- 2020-01-18